Objectives:To study the distribution status

clinical manifestations and laboratory test characteristics of alpha-thalassaemia gene type in the city of ChongQing to approach the importance of genetic diagnosis for alpha-thalassaemia

and the significance of thia diagnosis for antenatal screening and prenatal diagnosis to promote the survival quality of human being.Methods:This study was performed in the Children’s Hospital of Chongqing Medical University.One hundred and three alpha -thalassaemia patients were involved in this study.They had taken the tests of serum iron(SI)

total iron binding capacity(TIBC)

transferrin saturation(TS)

hemoglobin(Hb)electrophoresis and genetic examination.Retrospective study and prospective study were performed with the results.Results:(1)A total of 72 patients underwent SI

TIBC and TS

and 55.56 %(40/72) patients had SI decreased

TIBC increased and TS decreased.(2) 92 serum samples from these patients had Hb electrophoresis

in which 31.52%(29/92) presented fast band.(3) In this study

there were 82.52%(85/103) deletional alpha-thalassaemia and 17.48%(18/103) non-deletional alpha-thalassaemia.(4) In 85 deletional alpha-thalassaemia

alpha0-thalassaemia was more than alpha+-thalassaemia.Conclusion:(1) Deletion form is the main form of α thalassaemia in ChongQing.(2) alpha0-thalassaemia is less than alpha+-thalassaemia.(3) Genetic diagnosis is the gold standard for this disease.(4) It should be emphasized that antenatal screening and prenatal diagnosis are important for better lives of human beings.(5) Alpha-thalassaemia can affiliate nutritional iron deficiency anemia(NIDA).