Content determination of trace kryptofix 222 in <sup>18</sup>F-fluorodeoxyglucose

LI Qi-ming; et al

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Content determination of trace kryptofix 222 in ¹⁸F-fluorodeoxyglucose

更新时间：2024-01-17

- Content determination of trace kryptofix 222 in ¹⁸F-fluorodeoxyglucose
- Journal of Chongqing Medical University Vol. 34, Issue 8, Pages: 1057-1059(2009)
- 作者机构：
  
  第三军医大学大坪医院野战外科研究所核医学科PET中心
- 作者简介：
- 基金信息：
- DOI：
  CLC： R927.2
- Published：2009，
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[1]李奇明,金榕兵,唐维佳.~(18)F-氟脱氧葡萄糖中微量氨基聚醚(2.2.2)含量测定[J].重庆医科大学学报,2009,34(08):1057-1059.

LI Qi-ming, et al. Content determination of trace kryptofix 222 in ¹⁸F-fluorodeoxyglucose. [J]. Journal of Chongqing Medical University 34(8):1057-1059(2009)
[1]李奇明,金榕兵,唐维佳.~(18)F-氟脱氧葡萄糖中微量氨基聚醚(2.2.2)含量测定[J].重庆医科大学学报,2009,34(08):1057-1059. DOI：

LI Qi-ming, et al. Content determination of trace kryptofix 222 in ¹⁸F-fluorodeoxyglucose. [J]. Journal of Chongqing Medical University 34(8):1057-1059(2009) DOI：

摘要

目的:建立18F-氟脱氧葡萄糖中微量氨基聚醚（2.2.2）紫外分光光度检测方法。方法:在pH为6.4的柠檬酸氢氧化钠缓冲溶液中

加入适量苯甲醛和硝酸铅配制储备溶液

使溶液在250nm检测波长处的紫外吸收曲线为一平台

吸收值在0.4～0.6Abs间。在储备液中加入适量18F-氟脱氧葡萄糖溶液

用分光光度法检测微量氨基聚醚（2.2.2）铅（Ⅱ）络合物吸收值

定量测定氨基聚醚（2.2.2）。结果:在250nm下

氨基聚醚（2.2.2）的线性范围为0.0～10.0μg/ml

络合物摩尔吸光系数为1.6×104

定量限为0.13μg/ml。加样回收率在97.2%～102.7%

平均回收率为99.7%

相对标准偏差2.4%（n=5）。结论:该方法准确、灵敏

可用于18F-氟脱氧葡萄糖中微量氨基聚醚（2.2.2）含量测定。

Abstract

Objective:To establish an ultraviolet spectrophotometry method for determination of trace kryptofix 2.2.2 in 18F-fluorodeoxyglucose product.Method:A storage solution was prepared by adding properly benzaldehyde and lead nitrate to citric acid-NaOH buffer solution(pH = 6.4)

and ultralviolet absorbance curve of the solution was changed to platform at the wavelength of 250 nm nearby

and the absorbance value of this solution was 0.4Abs ~ 0.6Abs at 250 nm.Properly 18F-fluorodeoxyglucose product was added to storage solution

and the absorbance value of trace Pb(Ⅱ)-kryptofix 222 complex was detected by ultraviolet Spectrometry for quantitative determination of trace kryptofix 222.Results:The absorbance coefficient of complex was 1.6×104 L/(mol·cm) at 250 nm;the linear range of kryptofix 222 was 0.0μg/ml~10.0μg/ml

the limit ofkryptofix 222 was 0.0μg/ml~10.0μg/ml

the limit of quantification was 0.13μg/ml;the adding recovery was 97.2%～102.7%

with the average recovery of 99.7%;the relative standard deviation(RSD) was 2.4%(n=5).Conclusion:The method was specific

sensitive and suitable for determination of trace kryptofix 2.2.2 in 18F-fluorodeoxyglucose product.

关键词

18F-氟脱氧葡萄糖氨基聚醚（2.2.2）紫外分光光度法含量测定

Keywords

18F-FluorodeoxyglucoseKryptofix 222Ultraviolet Spectrophotometrycontent determination

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Content determination of trace kryptofix 222 in 18F-fluorodeoxyglucose

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摘要

Abstract

关键词

Keywords

references

Content determination of trace kryptofix 222 in ¹⁸F-fluorodeoxyglucose