Rapid establishment of rabbit model of mammary dysplasia and its estrogen receptor alpha distribution

LI Sheng; et al

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Rapid establishment of rabbit model of mammary dysplasia and its estrogen receptor alpha distribution

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- Rapid establishment of rabbit model of mammary dysplasia and its estrogen receptor alpha distribution
- Journal of Chongqing Medical University Vol. 34, Issue 11, Pages: 1534-1537(2009)
- 作者机构：
  
  重庆医科大学生物医学工程系重庆市生物医学工程学重点实验室重庆市超声医学工程重点实验室省部共建国家重点实验室培育基地
- 作者简介：
- 基金信息：
- DOI：
  CLC： R-332;R655.8
- Published：2009，
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[1]黎升,朱辉,王智彪.兔乳腺增生模型的快速制备及ERα分布[J].重庆医科大学学报,2009,34(11):1534-1537.

LI Sheng, et al. Rapid establishment of rabbit model of mammary dysplasia and its estrogen receptor alpha distribution. [J]. Journal of Chongqing Medical University 34(11):1534-1537(2009)
[1]黎升,朱辉,王智彪.兔乳腺增生模型的快速制备及ERα分布[J].重庆医科大学学报,2009,34(11):1534-1537. DOI：

LI Sheng, et al. Rapid establishment of rabbit model of mammary dysplasia and its estrogen receptor alpha distribution. [J]. Journal of Chongqing Medical University 34(11):1534-1537(2009) DOI：

摘要

目的:探讨快速制备兔乳腺增生的可行性。方法:用苯甲酸雌二醇（Estradiol benzoate

E2）和黄体酮肌注新西兰大白兔

动态观察有无乳腺增生及模型维持时间

病理类型

雌激素受体α（Estrogen receptor alpha

ERα）分布情况。结果:20～25 d即可制备该模型

符合乳腺增生的病理特征

无须切除卵巢

模型可维持135 d左右。结论:模型成功率高

稳定性好

具有与人类基本相似的病理特征

快速建模是可行的。

Abstract

Objective:To investigate the feasibility of rapidly making rabbit model of mammary hyperplasia.Methods:Estradiol benzoate and Progesterone were given intramuscularly to New Zealand white rabbits during different periods.The preparation of the model

its available time

pathological type and estrogen receptor alpha distribution were observed.Results:After 20~25 days

the models were estabished

which fulfilled the features of mammary dysplasia

making ovariectomy unnecessary.The model could be maintained for 135 days.Conclusion:The model has the same pathological feature with human.Rapid modeling is feasible

with high successful rate.

关键词

兔乳腺增生模型雌激素受体

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