Preparation and characteristics of BCUN- loaded lipid ultrasound contrast agent

ZHANG Xue-hua; et al

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Preparation and characteristics of BCUN- loaded lipid ultrasound contrast agent

更新时间：2024-01-17

- Preparation and characteristics of BCUN- loaded lipid ultrasound contrast agent
- Journal of Chongqing Medical University Vol. 34, Issue 11, Pages: 1538-1541(2009)
- 作者机构：
  
  1. 重庆医科大学附属儿童医院超声科
  2. 重庆医科大学超声影像研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC： R943
- Published：2009，
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[1]张雪华,李映良,全学模,王志刚,李攀,唐毅.载卡莫司汀脂质超声造影剂制备及特性的研究[J].重庆医科大学学报,2009,34(11):1538-1541.

ZHANG Xue-hua, et al. Preparation and characteristics of BCUN- loaded lipid ultrasound contrast agent. [J]. Journal of Chongqing Medical University 34(11):1538-1541(2009)
[1]张雪华,李映良,全学模,王志刚,李攀,唐毅.载卡莫司汀脂质超声造影剂制备及特性的研究[J].重庆医科大学学报,2009,34(11):1538-1541. DOI：

ZHANG Xue-hua, et al. Preparation and characteristics of BCUN- loaded lipid ultrasound contrast agent. [J]. Journal of Chongqing Medical University 34(11):1538-1541(2009) DOI：

摘要

目的:制备载卡莫司汀脂质超声造影剂

检测其物理性状与造影增强效果。方法:采用机械振荡法制备载卡莫司汀脂质超声造影剂

显微镜下观察并计算其浓度、马尔文测量粒径大小、分布、电位

高效液相色谱法测量药物的包封率。微泡经冷冻干燥与60Co辐照消毒后

经兔耳缘静脉注射

观察其在兔肝内显像效果。结果:载药脂质造影剂的浓度为（2.6～3.1）×109/ml

平均粒径为（1.05±0.20）μm;卡莫司汀包封率为42.6%±0.11%;电位为-（12.93±1.84）mV;经兔耳缘静脉注射后

兔肝内可见持续的增强显像效果。结论:成功制备的卡莫司汀脂质超声造影剂

有望为肿瘤的靶向治疗提供新方向。

Abstract

Objective:To preparate BCUN-loaded lipid ultrasound contrast agent and detect its physical properties and contrast-enhancing effects.Methods:Mechanical oscillation was used to prepare BCUN-loaded lipid contrast agent.Density was detected and analyzed with microscope.Malvern determined intensity

disposition and Zeta potential.RP-HPLC detected envelopment rate.Cryodesiccated-microb ubbles were sterilized by 60Co irradiation.Following injected it through rabbit ear vein

effects of ultrasounic enhanced imaging in rabbit liver was observed.Results:The density of microbubble was(2.6~3.1)×109/ ml.The mean intensity was(1.05±0.20)μm.The mean Zeta potential was(12.93±1.84)mV.The mean nvelopment rate was(42.6±0.11)%.After injecting this microbubble

good and sustained ultrasounic enhanced images in rabbit liver were seen.Conclusions:BCUN-loaded lipid contrast agents were successfully prepared

which hopefullyprovide a new option oftargetingtreatment for the tumor.

关键词

超声造影剂卡莫司汀兔微泡

Keywords

Ultrasound constrast agentCammustinerabbitmicrobubble

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