Protective effects of magnesium tanshinone ⅡA sulfonate on acute myocardial infarction in rats

ZHANG Yu-fang; et al

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Protective effects of magnesium tanshinone ⅡA sulfonate on acute myocardial infarction in rats

更新时间：2024-01-17

- Protective effects of magnesium tanshinone ⅡA sulfonate on acute myocardial infarction in rats
- Journal of Chongqing Medical University Vol. 34, Issue 12, Pages: 1676-1678(2009)
- 作者机构：
  
  1. 重庆市江北区第一人民医院药剂科
  2. 重庆医科大学附属第二医院药剂科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R285.5
- Published：2009，
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[1]张玉方,赵春景.丹参酮ⅡA磺酸镁对大鼠急性心肌梗死的保护作用及机制[J].重庆医科大学学报,2009,34(12):1676-1678.

ZHANG Yu-fang, et al. Protective effects of magnesium tanshinone ⅡA sulfonate on acute myocardial infarction in rats. [J]. Journal of Chongqing Medical University 34(12):1676-1678(2009)
[1]张玉方,赵春景.丹参酮ⅡA磺酸镁对大鼠急性心肌梗死的保护作用及机制[J].重庆医科大学学报,2009,34(12):1676-1678. DOI：

ZHANG Yu-fang, et al. Protective effects of magnesium tanshinone ⅡA sulfonate on acute myocardial infarction in rats. [J]. Journal of Chongqing Medical University 34(12):1676-1678(2009) DOI：

摘要

目的:探讨丹参酮ⅡA磺酸镁（Magnesium tanshinone Ⅱ A sulfonate

MTS）对急性心肌梗死的保护作用及其作用机制。方法:用冠状动脉结扎法制备大鼠急性心肌梗死模型

并将成功模型大鼠随机分为5%葡萄糖溶液对照组、丹参酮ⅡA磺酸钠组、丹参酮ⅡA磺酸镁低、中、高剂量组。结扎后5min通过尾静脉分别给予相应剂量的药物并于4h后测定大鼠心肌梗死范围以及血清和心肌组织中酶的活性。结果:与对照组比较

丹参酮ⅡA磺酸镁能剂量依赖性降低模型血清肌酸激酶（Creatine phos phokinase

CK）和乳酸脱氢酶（Lactic acid dehydrogenase

LDH）活性;减少心肌梗死范围;提高心肌组织超氧化物歧化酶（Superoxide dismutase

SOD）活性

同时降低丙二醛（Malondiadehyde

MDA）含量。结论:丹参酮ⅡA磺酸镁对急性心肌梗死有保护作用

其保护机制与抗氧自由基作用有关。

Abstract

Objective:To investigate the protective effects and its protective mechanism of Magnesium tanshinone ⅡA sulfonate(MTS) on acute myocardial infarction.Methods:The acute myocardial infarction model in rats were performed by the ligation of the left coronaryartery and the successful models were randomly assigned to either a control group(5% glucose solutions) sodium tanshinone ⅡA sulfonate(STS)group(5 mg/kg)

combined MTS group(1

15 mg/kg).The corresponding dosages medicine were given to that rats 5 minutes after ligationing through the vena caudalis;The myocardial infarct size

change of enzymes in myocardium and serum were simultaneously monitered 4 hours later.Results:Comparing with control group it was found that MTS decreased the lactic acid dehydrogenase(LDH) and creatine phosphokinase(CK)activity in serum

reduced myocardial infarct size

and improved the activity of superoxide dismutase(SOD) and decreased the malondiadehyde(MDA)contents in myocardium respectively.Conclusion:MTS had protective effects on the acute myocardial infarction by the ligation

the mechanism of the protective effect may be related to its role against oxygen free radical.

关键词

丹参酮ⅡA磺酸镁心肌梗死心肌保护氧自由基

Keywords

Magnesium tanshinone ⅡA sulfonatemyocardial infarctionmyocardial protectionOxygen free radical

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