Effect of cinnarizine on glutaminergic neuron in the dysmnesia models induced by quinolinic acid

SU Yuan-qi; et al

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Effect of cinnarizine on glutaminergic neuron in the dysmnesia models induced by quinolinic acid

更新时间：2024-01-17

- Effect of cinnarizine on glutaminergic neuron in the dysmnesia models induced by quinolinic acid
- Journal of Chongqing Medical University Vol. 34, Issue 12, Pages: 1658-1660(2009)
- 作者机构：
  
  1. 重庆医药高等专科学校药理教研室
  2. 重庆医科大学药理学教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R96
- Published：2009，
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[1]苏湲淇,董志.桂利嗪对喹啉酸致学习记忆障碍谷氨酸能神经元的影响[J].重庆医科大学学报,2009,34(12):1658-1660.

SU Yuan-qi, et al. Effect of cinnarizine on glutaminergic neuron in the dysmnesia models induced by quinolinic acid. [J]. Journal of Chongqing Medical University 34(12):1658-1660(2009)
[1]苏湲淇,董志.桂利嗪对喹啉酸致学习记忆障碍谷氨酸能神经元的影响[J].重庆医科大学学报,2009,34(12):1658-1660. DOI：

SU Yuan-qi, et al. Effect of cinnarizine on glutaminergic neuron in the dysmnesia models induced by quinolinic acid. [J]. Journal of Chongqing Medical University 34(12):1658-1660(2009) DOI：

摘要

目的:研究桂利嗪（Cinnarizine

Cin）对兴奋毒喹啉酸（Quinolinic acid

QA）损伤的谷氨酸（Glutaminergic

Glu）能神经系统是否有保护作用

并研究其相关机制。方法:应用微量注射方法

将喹啉酸注入大鼠双侧海马CA1区

建立大鼠学习记忆障碍模型

探讨cin对QA损伤海马神经元保护作用及其相关作用机制。结果:桂利嗪可降低QA损伤大鼠Morris水迷宫实验中其寻找平台平均潜伏期及穿梭箱实验中其回避潜伏期

与模型组比较有显著性差异;使大鼠学习记忆障碍模型脑神经元病理改变减轻

并明显减轻其脑组织病理损伤;能明显增加QA损伤大鼠海马中Glu阳性神经元的数量。结论:桂利嗪能通过减轻Glu能神经系统的损伤来改善模型大鼠学习记忆能力。

Abstract

Objective:To study the protective effect of Cinnarizine induced by QA and its related mechanism.Methods:Rat models of dysmnesia were made by injecting QA into CA1 districts of hippocampuses with microinjector to explore the protective effect of Cin and its related factors on QA induced impairment of hippocampuses neuron.Results:Compared with control group

in Morris water maze test time of finding the platform under the water surface decreased

and in step-through test the latent period rose.Cin could also decrease the pathological alterations of brain nerve cells in dysmnesia models.The above results indicated that Cin could not only improve the dysmnesia in rat models

but also decreased the pathologic damage in brain tissue.The number of glutaminergic neuron positive nerve cells was increased.Conclusion:Cin could improve the dysmnesia in rat models by mitigating damage in glutaminergic neuron.

关键词

学习记忆障碍谷氨酸能神经元喹啉酸模型

Keywords

DysmnesiaGlutaminergic neuronQuinolinic acidModels

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Department of Pharmacology,School of Pharmacy,Chongqing Medical University

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