Comparison of variance of weights in meta-analysis models and its correlation with I-square

SHI Xiu-quan; LIU Dan; LIU Jun

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Comparison of variance of weights in meta-analysis models and its correlation with I-square

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- Comparison of variance of weights in meta-analysis models and its correlation with I-square
- Journal of Chongqing Medical University Vol. 36, Issue 11, Pages: 1350-1352(2011)
- 作者机构：
  
  遵义医学院公共卫生学院流行病与卫生统计学教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R195
- Published：2011，
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[1]石修权,刘丹,刘俊.Meta分析模型权重变异比较及其与I2的相关性[J].重庆医科大学学报,2011,36(11):1350-1352.

SHI Xiu-quan, LIU Dan, LIU Jun. Comparison of variance of weights in meta-analysis models and its correlation with I-square. [J]. Journal of Chongqing Medical University 36(11):1350-1352(2011)
[1]石修权,刘丹,刘俊.Meta分析模型权重变异比较及其与I2的相关性[J].重庆医科大学学报,2011,36(11):1350-1352. DOI：

SHI Xiu-quan, LIU Dan, LIU Jun. Comparison of variance of weights in meta-analysis models and its correlation with I-square. [J]. Journal of Chongqing Medical University 36(11):1350-1352(2011) DOI：

摘要

目的:探讨Meta分析中2种模型的权重变异（方差）的差异及其与异质性I2的关系。方法:检索近3年公开发表的Meta分析论文

提取每篇纳入文献的权重以及I2

并计算权重的变异度（方差值）。比较不同模型下权重方差的差异并考察权重方差与I2的相关性。结果:随机效应模型的权重方差小于固定效应模型（t=2.739

P=0.015）;权重方差与I2之间r=-0.505

P=0.039。结论:随机效应模型中原始研究的权重变异低于固定效应模型

且权重方差与I2间呈负相关。深入探讨权重变异差异及其与异质性的关系

对正确理解2种模型权重赋予的原则

甚至对Meta分析的学习和结果的合理解释均具有重要意义。

Abstract

Objective:To explore the difference in variance of weights(s2w) between two models and its correlation with I-square of heterogeneity(I2) in meta-analyses.Methods:Weights and I2 were extracted from meta-analyses which were published in recent three years

then s2w were computed.The difference in s2w was compared between two models and the correlation was investigated between s2w s2w and I2.Results:s2w in random-effect model was lower than that in fixed-effect model(t=2.739

P=0.015);and the correlation coefficient between s2w and I2 was-0.505 and P-value was 0.039.Conclusion:s2w in random-effect model is significantly lower than fixed-effect model and a negative correlation between s2w and I2 exists.It is important to understand how to assign weight in two models

even in the study and suitable explanation of the results in meta-analyses if the reasons of s2w difference and correlation between I2 and s2w are thoroughly searched.

关键词

Meta分析模型I2权重相关性

Keywords

Meta-analysismodelI-squareweightcorrelation

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