Screening and optimizing the lung cancer related tumor markers from multi-tumor marker protein chip

ZHAO Shun-lin1; HU Wei-dong2; XU Wen-bo2; LIU Yue2; WU Zhou-qing2

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Screening and optimizing the lung cancer related tumor markers from multi-tumor marker protein chip

更新时间：2024-01-17

- Screening and optimizing the lung cancer related tumor markers from multi-tumor marker protein chip
- Journal of Chongqing Medical University Vol. 36, Issue 11, Pages: 1353-1356(2011)
- 作者机构：
  
  1. 武汉市江夏区第一人民医院肿瘤科
  2. 武汉大学中南医院肿瘤科湖北省肿瘤医学临床研究中心肿瘤生物学行为湖北省重点实验室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R734.2
- Published：2011，
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[1]赵顺林,胡卫东,徐闻博,刘越,吴洲清.肿瘤标志物蛋白芯片中肺癌相关指标的筛选优化[J].重庆医科大学学报,2011,36(11):1353-1356.

ZHAO Shun-lin1, HU Wei-dong2, XU Wen-bo2, et al. Screening and optimizing the lung cancer related tumor markers from multi-tumor marker protein chip. [J]. Journal of Chongqing Medical University 36(11):1353-1356(2011)
[1]赵顺林,胡卫东,徐闻博,刘越,吴洲清.肿瘤标志物蛋白芯片中肺癌相关指标的筛选优化[J].重庆医科大学学报,2011,36(11):1353-1356. DOI：

ZHAO Shun-lin1, HU Wei-dong2, XU Wen-bo2, et al. Screening and optimizing the lung cancer related tumor markers from multi-tumor marker protein chip. [J]. Journal of Chongqing Medical University 36(11):1353-1356(2011) DOI：

摘要

目的:分析多种肿瘤标志物（Tumor marker

TM）与肺癌的相关性

筛选相关指标

为建立检测肺癌的小型蛋白芯片提供依据。方法:使用TM蛋白芯片系统

检测311例肺癌患者血清中多种TM:癌抗原125（Cancer antigen 125

CA125）、癌抗原153（Cancer antigen 153

CA153）、糖链抗原199（Carbohydrate antigen

CA199）、癌胚抗原（Carcinoembryonic antigen

CEA）、甲胎蛋白（Alpha fetoprotein

AFP）、铁蛋白（Ferritin

FER）、游离型前列腺特异性抗原（Free prostate specific antigen

free-PSA）及前列腺特异性抗原（Prostate specific antigen

PSA）的水平。筛选出肺癌中阳性率高的的指标

采用Kappa检验比较其与TM蛋白芯片系统检测结果的一致性

寻找最佳联检组合。结果:311例肺癌患者中TM升高主要集中在4项指标:CEA（41.5%）、CA153（15.2%）、CA199（20.9%）、CA125（37.0%）;Kappa检验得出

一致性极强的小型组合有5种

使用成本-效果分析法得出最佳组合为CA125+CEA。结论:血清CEA和CA125水平升高对肺癌的诊断有较高的临床价值

选择CA125+CEA联合检测

可以在不降低检出率的情况下降低检测成本。

Abstract

Objective:To screen and optimize the lung cancer related tumor markers from multi-tumor marker protein chip.Methods:With the multi-tumor marker protein chip

the sera of 311 patients with lung cancer were detected for multi-tumor markers including carcinoembryonic antigen(CEA)

alpha fetoprotein(AFP)

carbohydrate antigen 199(CA199)

cancer antigen 153(CA153)

cancer antigen 125(CA125)

prostate specific antigen(PSA)

free-PSA

and ferritin.Lung cancer related parameters were analyzed by Kappa test and cost-effectiveness analysis.Results:There were four kinds of tumor markers which were apparently increased in the serum among the 311 lung cancer patients:CEA(41.5%)

CA153(15.2%)

CA199(20.9%)

and CA125(37.0%).Five tumor marker combinations were found to be strongly consistent with the results of multi-tumor marker protein chip by Kappa test

and the combination of CEA with CA125 was proved to be the best by cost-effectiveness analysis.Conclusion:The combined detection of sera CEA and CA125 is helpful to diagnose lung cancer

which is consistent with the positive rate of diagnosis by using multi-tumor marker protein chip and the two combination test can cut down the cost of diagnosis of lung cancer.

关键词

肿瘤标志物肺癌诊断

Keywords

tumor markerslung cancerdiagnosis

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Department of Radiology，The First Affiliated Hospital of Chongqing Medical University

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