Efficacy and safety of ranolazine in the treatment of type 2 diabetes mellitus：a Meta-analysis

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Efficacy and safety of ranolazine in the treatment of type 2 diabetes mellitus：a Meta-analysis

更新时间：2023-12-22

- Efficacy and safety of ranolazine in the treatment of type 2 diabetes mellitus：a Meta-analysis
- Journal of Chongqing Medical University Vol. 43, Issue 3, Pages: 462(2018)
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- Published：2018，
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Efficacy and safety of ranolazine in the treatment of type 2 diabetes mellitus：a Meta-analysis. [J]. Journal of Chongqing Medical University 43(3):462(2018)
DOI：

Efficacy and safety of ranolazine in the treatment of type 2 diabetes mellitus：a Meta-analysis. [J]. Journal of Chongqing Medical University 43(3):462(2018) DOI：

摘要

目的：系统评价雷诺嗪治疗2型糖尿病（diabetes mellitus type 2，T2DM）的疗效与安全性。方法：全面检索CENTRAL、Medline、Embase、CNKI、VIP、CBM、Wanfang数据库，以及WHO临床试验注册平台和美国临床试验注册平台，对检索到的随机对照试验（randomized controlled trial，RCT）按Cochrane系统评价方法进行质量评价，并用RevMan 5.2软件进行 Meta分析。结果：共纳入7个RCTs，3 131例患者。Meta分析显示：雷诺嗪（1 000 mg bid）单药治疗与安慰剂相比可降低糖化血红蛋白（gly－cosylated hemoglobin，HbA1c）（MD=-0.55，95%CI=-0.73~-0.37，P=0.000），空腹血糖（fasting plasma glucose，FPG）（SMD=-0.19，95%CI=-0.37~-0.01，P=0.04），餐后2 h血糖（postprandial 2 hours blood glucose，2hPG）（SMD=-0.34，95%CI=-0.53~-0.15，P=0.000 5）。在降糖药治疗基础上，雷诺嗪（1 000 mg bid）与安慰剂相比可降低HbA1c（MD=-0.47，95%CI=-0.62~-0.32，P=0.000），两组降低FPG（SMD=-0.00，95%CI=-0.21~0.20，P=0.97）及2hPG（SMD=-0.12，95%CI=-0.33~0.09，P=0.28）的作用相当；雷诺嗪（750 mg bid）与安慰剂相比可降低HbA1c（MD=-0.48，95%CI=-0.85~-0.11，P=0.01），两组降低FPG（SMD=0.11，95%CI=-0.26~0.48，P=0.57）的作用相当；雷诺嗪（500 mg bid）与曲美他嗪相比降低HbA1c（MD=-0.30，95%CI=-1.35~0.75，P=0.58），FPG（SMD=-0.36，95%CI=-0.94~0.22，P=0.22）及2hPG（SMD=0.15，95%CI=-0.42~-0.73，P=0.60）的作用相当。雷诺嗪不增加低血糖风险（RR=1.24，95%CI=0.80~1.93，P=0.34）。结论：雷诺嗪对T2DM患者有一定降低HbA1c水平作用且安全性良好，其降糖机制与抑制胰高血糖素释放有关。

Abstract

Objective：To evaluate the efficacy and safety of ranolazine in the treatment of diabetes mellitus type 2 （T2DM）. Methods：CENTRAL，Medline，EMbase，CNKI，VIP，CBM，Wanfang database，WHO Clinical Trials Registry Platform and ClinicalTrials.gov were searched. The quality of included randomized controlled trials was assessed according to the Cochrane Collaboration system review，and then Meta-analysis was performed using RevMan 5.2. Results：A total of 7 randomized controlled trials（RCTs） were enrolled in－cluding 3 131 patients. Meta-analysis showed that ranolazine（1 000 mg bid） monotherapy compared with placebo resulted in a signif－icant reduction in HbA1c（MD=-0.55，95%CI=-0.73 to -0.37，P=0.000），in FPG（SMD=-0.19，95%CI=-0.37 to -0.01，P=0.04），in 2hPG（SMD=-0.34，95%CI=-0.53 to -0.15，P=0.000 5）. As an add-on interaction with antidiabetes compared with placebo，ranolazine（1 000 mg bid） resulted in a significant reduction in glycosylated hemoglobin（HbA1c）（MD=-0.47，95%CI=-0.62 to -0.32，P=0.000），a similar reduction in fasting blood-glucose （FPG）（SMD=-0.00，95%CI=-0.21 to 0.20，P=0.97），in postprandial 2 hours blood glucose（2hPG）（SMD=-0.12，95%CI=-0.33 to 0.09，P=0.28），ranolazine（750 mg bid） resulted in a significant reduction in HbA1c（MD=-0.48，95%CI=-0.85 to -0.11，P=0.01），a similar reduction in FPG（SMD=0.11，95%CI=-0.26 to 0.48，P=0.57）. When add-on to antidiabetes ranolazine（500 mg bid） compared with trimetazidine elicited a similar reduction in HbA1c（MD=-0.30，95%CI=-1.35 to 0.75，P=0.58），in FPG（SMD=-0.36，95%CI=-0.94 to 0.22，P=0.22），in 2hPG（SMD=0.15，95%CI=-0.42 to -0.73，P=0.60）. Ranolazine didn’t increase the risk of hypoglycemia（RR=1.24，95%CI=0.80 to 1.93，P=0.34）. Conclusion：Ranolazine can effectively reduce HbA1c level by inhibiting glucagon secretion and safe for adults with T2DM.

关键词

雷诺嗪2型糖尿病Meta分析随机对照试验

Keywords

ranolazinediabetes mellitus type 2（T2DM）Meta-analysisrandomized controlled trial

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