Objective To observe the effect of femtosecond laserassisted deep anterior lamellar keratoplasty (DALK) combined with tacrolimus in the treatment of infectious keratitis. Methods Sixtyfour patients with infectious keratitis admitted into our hospital from March 2015 to March 2018 were selected as the research objects and divided into two groups according to the surgical approach

with 32 cases in each group.Patients of the two groups were given standard antiinfective drugs for 2 weeks after diagnosis. Patients of the observation group were treated with femtosecond laserassisted DALK

while patients of the control group were treated with penetrating keratoplasty. And tacrolimus eye drops were used in both of the two groups after operation. The curative effect

best corrected visual acuity

immune rejection reaction

corneal surface curvature and adverse reactions were observed and compared between the two groups. Results The effective rate of the observation group (90.63%) was significantly higher than that of the control group (65.63%)

with significant difference between the two groups (P=0.016). The corrected visual acuity of the patients in the observation group was better than that of the control group in 1 month

3 months and 6 months after operation. The immune rejection reaction of patients in the observation group was significantly lower than that of the control group in 7 days and 14 days after treatment; the intraocular pressure of patients in the observation group was significantly lower than that of the control group in 7 days

1 month and 3 months after operation. After 6 months

the intraocular pressure of the patients in the two groups tended to stabilize. There was no significant difference in corneal surface curvature between the two groups before and after treatment. There was no significant adverse reactions in both of the two groups.Conclusion Femtosecond laserassisted DALK combined with tacrolimus significantly improves the postoperative visual acuity and intraocular pressure in patients with infectious keratitis

and it is of significant treatment effect and high safety.