Study on antiinflammatory and anti-oxidative effects of chrysin in early brain injury after subarachnoid hemorrhage in rats

PENG Hua; TANG Xiaoping; SUN Haogeng; YANG Binbin; XIONG Ping; ZHANG Tao; ZHAO Long; DUAN Junwei

您当前的位置：

首页 >

文章列表页 >

Study on antiinflammatory and anti-oxidative effects of chrysin in early brain injury after subarachnoid hemorrhage in rats

更新时间：2023-05-22

- Study on antiinflammatory and anti-oxidative effects of chrysin in early brain injury after subarachnoid hemorrhage in rats
- null Issue 8, Pages: 608(2019)
- 作者机构：
  
  川北医学院附属医院神经外科,四川,南充,637000
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2019，
扫描看全文
PENG Hua, TANG Xiaoping, SUN Haogeng, et al. Study on antiinflammatory and anti-oxidative effects of chrysin in early brain injury after subarachnoid hemorrhage in rats. [J]. null (8):608(2019)
DOI：

PENG Hua, TANG Xiaoping, SUN Haogeng, et al. Study on antiinflammatory and anti-oxidative effects of chrysin in early brain injury after subarachnoid hemorrhage in rats. [J]. null (8):608(2019) DOI：

摘要

目的探讨白杨素在大鼠蛛网膜下腔出血（SAH）早期脑损伤中的抗炎和抗氧化应激作用。方法建立SAH大鼠模型，将112只大鼠随机分为7组，分别在不同时期给予不同剂量白杨素干预后，检测每组大鼠脑组织中细胞因子（IL-6、IL-1β、TNF-α）和氧化应激产物（MDA、SOD、ROS）水平，并检测脑组织含水量和神经功能评分。结果白杨素干预可以显著降低IL-6、IL-1β、TNF-α、MDA、ROS水平，增加SOD活性，且早期干预效果优于晚期干预，高剂量白杨素效果优于低剂量组，差异具有统计学意义（P<0.05）；白杨素干预可以降低脑组织含水量，减轻水肿，差异具有统计学意义（P<0.05）；早期高剂量白杨素干预可以显著改善神经功能评分，差异具有统计学意义（P<0.05）。结论蛛网膜下腔出血早期白杨素干预可以显著降低炎症和氧化应激，改善脑水肿和神经功能评分。

Abstract

Objective To investigate the antiinflammatory and antioxidative effects of chrysin in early brain injury after subarachnoid hemorrhage (SAH) in rats. Methods Established the rat model of SAH

and randomly divided 112 rats into 7 groups.The cytokines(IL-6

IL-1β

TNF-α) and oxidative stress products (MDA

ROS

SOD) levels in brain tissue of each group were detected

and the water content and neurological function scores of brain tissue were detected as well. Results The levels of IL-6

IL-1β

TNF-α

MDA and ROS were significantly decreased with chrysin intervention while the SOD activity was significantly increased. The effect of early intervention was better than that of late intervention (P<0.05)

and the effect of highdose chrysin was better than that of lowdose chrysin (P<0.05).The brain water content and edema were reduced by chrysin intervention (P<0.05). The neurological function score was significantly improved after early intervention with highdose chrysin (P<0.05). Conclusion Early intervention with chrysin can significantly reduce inflammation and oxidative stress

and it can improve brain edema and neurological function score.

关键词

白杨素蛛网膜下腔出血脑损伤炎症氧化应激

Keywords

chrysinsubarachnoid hemorrhagebrain injuryinflammationoxidative stress

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Protective effect of hyperoside on paraquat-induced acute lung injury in rats

Efficacy and mechanism of fullerenol in promoting skin wound healing of mice

Effect of sinomenine on inflammatory reaction and early brain injury after subarachnoid hemorrhage

Chrysin attenuating renal tissue damage in rats with diabetes mellitus by inhibiting IRE1α/TXNIP/NLRP3 pathway

Mechanism of pterostilbene protecting HT22 cells from hydrogen peroxide-induced apoptosis

Related Author

WU Zhuo

CHEN Yue

WANG Qin-yu

GU Chun-yu

CHEN Xin-jun

LIANG Fu-cheng

HE Zhi-qiang

ZHANG Wei-nan

Related Institution

Department of Emergency Internal Medicine，Shaanxi Provincial People's Hospital

Department of Medical Equipment，Shaanxi Provincial People's Hospital

Department of Military Cognitive Psychology，Faculty of Medical Psychology，Army Medical University

the 31411th Troop Unit of PLA

Department of Plastic and Cosmetic Surgery，Daping Hospital of Amry Medical University

⁰