Efficacy of limbal stem cells transplantation combined with mitomycin C in treatment of pterygium

YANG Yitian; LI Mei; GUO Yinxia; ZHU Qixiu; BAO Zhongbao

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Efficacy of limbal stem cells transplantation combined with mitomycin C in treatment of pterygium

更新时间：2023-05-22

- Efficacy of limbal stem cells transplantation combined with mitomycin C in treatment of pterygium
- null Issue 5, Pages: 407(2019)
- 作者机构：
  
  六安市第二人民医院眼科
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2019，
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YANG Yitian, LI Mei, GUO Yinxia, et al. Efficacy of limbal stem cells transplantation combined with mitomycin C in treatment of pterygium. [J]. null (5):407(2019)
DOI：

YANG Yitian, LI Mei, GUO Yinxia, et al. Efficacy of limbal stem cells transplantation combined with mitomycin C in treatment of pterygium. [J]. null (5):407(2019) DOI：

摘要

目的探讨自体角膜缘干细胞移植术（LAT）联合丝裂霉素C（MMC）治疗翼状胬肉的疗效。方法选取我院眼科2016年6月至2017年9月收治的72例（96眼）翼状胬肉患者为研究对象，按照手术方法的不同分为观察组36例（58眼）和对照组36例（38眼）。观察组予LAT+MMC治疗，对照组行翼状胬肉单纯切除术。对比2组患者手术前后角膜散光度、术后并发症发生情况及术后3个月、6个月的复发情况，并进行相关统计学分析。结果 2组患者术后3个月的角膜散光度均有下降，观察组由（2.21±0．78）降至（0.75±0.29），对照组由（2．26±0．87）降至（1.89±0.81）

2组比较差异有统计学意义（P<0.05）；观察组术后3个月复发率（3.4%）、术后6个月复发率（3.4%）均低于对照组（21.1%、26.0%），2组比较差异有统计学意义（P＜0.05）；观察组术后并发症发生率为6.9%，对照组为7.8%，2组比较差异无统计学意义（P＞0.05）。结论 LAT与MMC联合治疗翼状胬肉能明显改善患者散光，且能显著降低术后复发率。

Abstract

Objective To investigate the longterm efficacy of Limbal autograft transplantation(LAT) combined with mitomycin C (MMC) in the treatment of pterygium. Methods A Total of 72 patients(96 eyes) with pterygium admitted into our hospital from June 2016 to September 2017 were divided into observation group(36 cases

58 eyes) and control group (36 cases

38 eyes) according to surgical method.The observation group was treated with LAT combined with MMC

and the control group underwent simple resection of pterygium.The corneal astigmatism

postoperative complications and recurrence in 3 months and 6 months after operation were compared between the two groups

and relevant statistical analysis was performed.Results Corneal astigmatism decreased in 3 months after operation of both groups

but the corneal astigmatism in the observation group decreased from (2.21±0.78) to (0.75±0.29)

while that in the control group decreased from (2.26±0.87) to (1.89±0.81)

the difference was significant（P<0.05）.The recurrence rates in 3 months (3.4%) and 6 months (3.4%) after operation of the observation group were lower than those of control group (21.1%

26.0%)

the differences were statistically significant(P<0.05). The incidence of postoperative complications was 6.9% in the observation group and 7.8% in the control group

the difference was not significant(P>0.05). Conclusion LAT combined with MMC in the treatment of pterygium can significantly improve astigmatism and reduce postoperative recurrence rates in patients.

关键词

角膜缘干细胞移植丝裂霉素C翼状胬肉疗效

Keywords

limbal stem cell transplantationmitomycin Cpterygiumefficacy

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