Detection and clinical significance of Tc17 cells in patients with inflammatory bowel disease

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Detection and clinical significance of Tc17 cells in patients with inflammatory bowel disease

更新时间：2023-05-22

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- Detection and clinical significance of Tc17 cells in patients with inflammatory bowel disease
- null Issue 5, Pages: 411(2019)
- 作者机构：
  
  1. 陆军军医大学第一附属医院消化内科
  2. 陆军军医大学基础医学院生物化学教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2019，
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CHEN Jing, LIU Dongbo, LU Xin. Detection and clinical significance of Tc17 cells in patients with inflammatory bowel disease. [J]. null (5):411(2019)
DOI：

CHEN Jing, LIU Dongbo, LU Xin. Detection and clinical significance of Tc17 cells in patients with inflammatory bowel disease. [J]. null (5):411(2019) DOI：

摘要

目的检测炎症性肠病患者外周血中Tc17细胞的变化并分析其临床意义。方法收集20例克罗恩病(CD)患者及20例溃疡性结肠炎(UC)患者的外周血，采用流式细胞术检测Tc17细胞的水平，另以20例健康人外周血作为正常对照。结果与正常对照相比，CD及UC患者外周血中Tc17细胞的比例均显著增加，差异具有统计学意义(P<0.05)，而CD组与UC组Tc17细胞水平比较差异无统计学意义(P>0.05)；CD及UC患者活动期的Tc17细胞比例显著高于缓解期(P<0.05)，但CD组与UC组在活动期或缓解期的Tc17细胞水平比较差异无统计学意义(P>0.05)。结论炎症性肠病患者外周血中Tc17细胞的比例显著增加，且与疾病的进展密切相关，监测其外周血Tc17细胞的水平有助于对疾病的活动度进行判断。

Abstract

Objective To explore the frequencies of Tc17 cells level in the peripheral blood of patients with inflammatory bowel disease (IBD) and their clinical significance.Methods The peripheral blood of 20 Crohns disease (CD) patients and 20 ulcerative colitis (UC) patients were collected in this study.The frequencies of Tc17 cells were analyzed by flow cytometry.The peripheral blood of 20 healthy donors was obtained as the control.Results Compared with healthy donors

the frequencies of Tc17 cells in CD and UC patients were significantly increased

the differences were significant(P<0.05)

but no statistical difference was observed between CD and UC group (P>0.05).Furthermore

the frequencies of Tc17 cells in active stage of CD and UC patients were also higher than those in remission stage (P<0.05)

but there was no statistical difference between CD active stage and UC active stage or CD remission stage and UC remission stage (P>0.05).Conclusion The proportion of circulating Tc17 cells were increased in the IBD patients

which is closely related to the progression of IBD

monitoring Tc17 cells in the peripheral blood of IBD patients may aid the judgment of disease activity.

关键词

炎症性肠病Tc17细胞外周血溃疡性结肠炎克罗恩病

Keywords

inflammatory bowel diseaseTc17 cellsperipheral bloodulcerative colitisCrohn′s disease

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