Objective To analyze the effect of interactive standard theory-based nursing intervention in patients undergoing thyroid cancer surgery. Methods A total of 80 patients with thyroid cancer who underwent surgery from September 2018 to September 2020 in a hospital in Liaoyang were selected as the subjects

who were randomly assigned to the control group（n=37） and the observation group（n=43） in accordance with admission order. Patients in the control group received routine nursing intervention and patients in the observation group interactive standard theory-based nursing intervention. Patients in both groups received continuous intervention for 2 months. Heart rate

psychological status [Self-rating Anxiety Scale（SAS） and Self-rating Depression Scale（SDS）]

service satisfaction score（health education

communication

and functional exercise scores）

and stress response were compared between the 2 groups 1 d before surgery and at 2 months of intervention. Results After the intervention

heart rate in the two groups were higher than those before the intervention

and the differences were statistically significant（P<0.05）. Heart rate in the observation group after the intervention were lower than those in the control group

and the differences were statistically significant（P<0.05）. The SAS and SDS scores in the two groups after the intervention were lower than those before the intervention

with the observation group lower than the control group

and the differences were statistically significant（P<0.05）. The scores for health education

communication

and functional exercise in the two groups after the intervention were higher than those before the intervention

with the observation group higher than the control group

and the differences were statistically significant（P<0.05）. The cortisol and angiotensin II levels in the two groups after the intervention were lower than those before the intervention

with the observation group lower than the control group

and the differences were statistically significant（P<0.05）. Conclusion The interactive standard theory-based nursing intervention can effectively improve the physical and psychological status of patients underwent thyroid cancer surgery

reduce stress response

and improve the satisfaction with nursing services. These benefits justify a wider application of this technique in clinical practice.