Objective To investigate the effect of post-hospital care based on the LACE risk model on the readmission rate of patients after percutaneous coronary intervention（PCI） for coronary artery disease.Methods Seventy-eight patients with coronary heart disease admitted to a hospital in Henan province from February 2018 to April 2020 were selected for this study.The patients were divided into observation group（n=39） and control group（n=39） according to the random number table method.Patients in the control group received conventional post-hospital care

and patients in the observation group were given nursing interventions based on the LACE risk model on the basis of the control group.The compliance status and secondary prevention knowledge rate of patients in the two groups at 2 months of intervention were compared;the coronary heart disease self-management scale（CSMS） scores and 6 min walk test（6 MWT） distance before and at 2 months of intervention were compared;the incidence of adverse cardiac events and readmission rate of patients in the two groups at 2 months of intervention were compared.Results The compliance rate of patients in the observation group was 94.87%

which was higher than that of 79.49% in the control group

and the difference was statistically significant（P<0.05）.The knowledge rate of secondary prevention was 97.44% in the observation group

higher than that of 79.49% in the control group

and the difference was statistically significant（P< 0.05）.After the intervention

the CSMS scores of patients in both groups were higher than those before the intervention

and the observation group had higher scores than the control group

while the 6 WMT distance of patients in both groups was longer than that before the intervention

and the observation group had longer than control group

and the differences were statistically significant（P< 0.05）.The incidence of adverse cardiac events was 2.56% in the observation group

which was lower than 20.51% in the control group

and the difference was statistically significant（P<0.05）.The readmission rate of patients in the observation group was 2.56%

lower than that of 23.08% in the control group

and the difference was statistically significant（P < 0.05）.Conclusion Nursing interventions based on LACE risk model applied to post-hospital care of patients with coronary artery disease after PCI can improve patients’ compliance behavior and knowledge of secondary prevention

improve patients’ self-management ability and exercise endurance

prevent adverse cardiac events and reduce readmission rate

and are worthy of clinical promotion.