Objective To investigate the value of 18F-fluordeoxyglucose positron emission tomography/co mputed tomography（18F-FDGPET/CT） imaging combined with serum vascular endothelial growth factor（VEGF）

soluble fms-like tyrosine kinase-1（sFLT1）

and endoglin（CD105） in predicting the value of endometrial cancer infiltration and metastasis.Methods Seventy-two patients with endometrial cancer treated from January 2019 to June 2020 in a hospital in Nanyang were selected for the study.Patients were divided into control group and study group according to pathological diagnosis.The control group were patients with non-infiltrating and non-metastatic endometrial cancer

totaling 42 cases;the study group were patients with infiltrating and metastatic endometrial cancer

totaling 30 cases.The maximum standardized uptake value（SUVmax） and mean standardized uptake value（SUVmean）

metabolic tumor volume（MTV）

total lesion glycolysis（TLG） and serum VEGF

sFLT1 and GD105 levels were compared between the 2 groups.Results The values of SUVmax

SUVmean

MTV and TLG in the study group were smaller than those in the control group

and the differences were all statistically significant（P<0.05）.Serum VEGF and CD105 levels were higher in the study group than in the control group（P<0.05）

while sFLT1 levels were lower than in the control group

and all differences were statistically significant（P<0.05）.The area under curve（AUC） of 18F-FDG PET/CT+VEGF+sFLT1+CD105 was 0.956（95% CI:0.915-0.998）.18 F-FDG PET/CT+VEGF+sFLT1+CD105 had the largest AUC

indicating the highest test accuracy.Conclusion The value of using SUVmax

SUVmean

MTV and TLG in combination with serum VEGF

sFLT1 and CD105 in 18F-FDG PET/CT imaging parameters to predict endometrial cancer infiltration and metastasis was higher than the predictive value of using imaging parameters and serological indicators alone.