Objective To investigate the effect of platelet-rich plasma（PRP） treatment on wound recovery in patients with chronic refractory wounds. Methods Eighty-six patients with chronic refractory wounds treated in a hospital in Dazhou from July 2019 to February 2021 were selected for the study

and the patients were randomly divided into a control group and a research group

with 43 cases each. The patients in the control group were treated with conventional dressing changes

while the patients in the research group were treated with PRP. The length of hospital stay

the rate of complete wound healing

and the length

width

and depth of the wounds at 90 d of treatment were compared between the two groups. Results Before treatment

the differences in wound size（length

width and depth） between the two groups were not statistically significant（P

>

0.05）. At 90 d of treatment

the wound size（length

width and depth） of the patients in the research group was significantly smaller than that in the control group

and the differences were statistically significant（P

<

0.01）. The hospitalization time of the patients in the research group was significantly shorter than that in the control group

and the difference was statistically significant（P

<

0.01）; the complete wound healing rate of patients in the observation group was 90.70%（39/43）

which was significantly higher than that of the control group（72.09%

31/43）

and the difference was statistically significant（χ

2

=4.914

P=0.027）. Conclusion PRP treatment for chronic refractory wounds is not only easy to operate

but also can effectively reduce the degree of damage to the patient’s organism and promote wound healing

which is economical and practical and has high application value and social benefits.