Objective To explore the effects of 6S management mode in the care of patients with craniocerebral injury. Methods One hundred and twenty patients with craniocerebral injury who were treated in a hospital in Henan Province from January 2019 to January 2020 were selected as the study subjects. The random number ta-ble method was used to divide the patients into observation group and control group

with 60 cases in each group. Patients in the control group received conventional nursing intervention

and the 6S management mode was used for the observation group based on the control group. The sputum volume on days 2

4 and 6 and sputum viscosi-ty on day 6 of the intervention were compared between the 2 groups; the National Institutes of Health stroke scale（NIHSS） scores were compared between the 2 groups at discharge; the occurrence of complications and nursing satisfaction at discharge were compared between the 2 groups. Results On days 2

4 and 6 of the inter-vention

patients in the observation group had higher sputum volume than those in the control group

and the differences were all statistically significant（P<0.05）. The proportion of patients in the observation group with sputum viscosity grade 0 and grade I was higher than that in the control group

and the proportion of patients with sputum viscosity grade II and grade III was lower than that in the control group

and the differences were statistically significant（P<0.05）. Before the intervention

there was no statistically significant difference between the NIHSS scores of patients in the 2 groups（P>0.05）. At the time of discharge

the NIHSS scores of patients in both groups were lower than those before the intervention

with those in the observation group lower than those in the control group

and the differences were statistically significant（P<0.05）. The complication rate of patients in the observation group was 6.64%

which was lower than 24.99% in the control group

and the difference was statistically significant（P<0.05）. The patient care satisfaction questionnaire in the observation group showed higher scores for treatment care

doctor-patient communication

patient trust

medical cost

and overall satisfaction than that in the control group

and the differences were statistically significant（P <0.05）. There was no statistically significant difference in the scores for admission service

environmental facilities

and medical meals in the patient care satisfaction questionnaire between the 2 groups（P>0.05）. Conclusion When applied to care for patients with craniocerebral injury

the 6S management model can promote sputum ex-cretion

reduce sputum viscosity

and lower NIHSS scores and complication rates. It would be highly recognized by patients and is worthy of clinical promotion and application.