Objective To investigate the effect of non-estrogenic drugs combined with topical anti-inflammatory drugs in the treatment of postmenopausal atrophic vaginitis.Methods Ninety-seven patients with postmenopausal atrophic vaginitis admitted to a hospital in Heilongjiang from May 2018 to March 2020 were selected for the study and divided into a control group（32 cases）

a non-estrogen combination group（33 cases）and an estrogen combination group（32 cases） using a random number table.Patients in the control group were given topical antiinflammatory drugs as monotherapy

patients in the non-estrogen combination group were treated with recombinant human-derived collagen vaginal gel on the basis of the control group

and patients in the estrogen combination group were treated with topical on the basis of the control group

all for 2 months.The vaginal symptoms and signs scores

acid-base balance

sex hormone levels

vaginal cell maturation

and inflammatory factor levels were compared before and after treatment in the three groups.Results Before treatment

there was no statistically significant difference in the scores of vaginal symptoms and signs among the 3 groups（P>0.05）;after treatment

the scores of vaginal symptoms and signs were lower than those before treatment in all 3 groups-and the difference was statistically significant（P<0.05）;after treatment

analysis of variance and two-by-two comparison revealed that the scores of vaginal symptoms and signs in the 3 groups were

ranked from the lowest to the highest

non-estrogen combination group

estrogen combination group

and control group.The difference was statistically significant（P<0.05）.Before treatment

there was no statistically significant difference in vaginal pH among the three groups（P>0.05）;after treatment

vaginal pH was lower than before treatment in all three groups

and the difference was statistically significant（P<0.05）;after treatment

analysis of variance and two-by-two comparison ranked the three groups

in terms of vaginal pH

as follows:that the non-estrogen combination group

estrogen combination group

and control group.The difference was statistically significant（P<0.05）.The differences in follicle-stimulating hormone（FSH）

luteinizing hormone（LH） and estradiol（E2） levels between the three groups before and after treatment were not statistically significant（P>0.05）.Before treatment

there was no statistically significant difference in vaginal exfoliative cell maturation index between the three groups（P>0.05）;after treatment

the vaginal exfoliative cell maturation index was higher in all three groups than before treatment

and the difference was statistically significant（P<0.05）;after treatment

analysis of variance and two-by-two comparison revealed that the vaginal exfoliative cell maturation indices of the three groups were

in descending order

non-estrogen combination group

estrogen combination group

and control group

and the difference was statistically significant（P>0.05）.The difference was statistically significant（P <0.05）.Before treatment

there was no statistically significant difference between the serum C-reactive protein（CRP） and interleukin-6（IL-6） levels of the three groups（P>0.05）;after treatment

the serum CRP levels of the three groups were higher than before treatment

and the IL-6 levels were lower than before treatment

and the difference was statistically significant（P<0.05）;after treatment

it was found by ANOVA and two-by-two comparison that the serum CRP and IL-6 level-s of the three groups were higher than before treatment

and the difference was statistically significant（P<0.05）.After treatment

by ANOVA and two-by-two comparison

it was found that the serum CRP and IL-6 levels in the three groups were

in ascending order

non-estrogen combination group

estrogen combination group

and control group

and the difference was statistically significant（P <0.05）.Conclusion Non-estrogenic drugs combined with topical anti-inflammatory drugs can effectively improve vaginal symptoms in postmenopau sal patients with atrophic vaginitis

regulate vaginal acid-base balance

help promote vaginal cell maturation and reduce inflammatory response

and have less effect on sex hormone levels.