Association between human epidermal growth factor receptor-2 expression and prognosis of non-small cell lung cancer:Systematic review

WANG Ying; ZHOU Jia

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Association between human epidermal growth factor receptor-2 expression and prognosis of non-small cell lung cancer:Systematic review

更新时间：2023-04-14

- Association between human epidermal growth factor receptor-2 expression and prognosis of non-small cell lung cancer:Systematic review
- Journal of Southwest Medical University Vol. 43, Issue 6, Pages: 564-570(2020)
- 作者机构：
  
  1. 西南医科大学临床医学院
  2. 西南医科大学人文与管理学院应用心理学教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R734.2
- Published：2020，
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[1]王英,周佳.Her-2表达与非小细胞肺癌预后关系的系统评价[J].西南医科大学学报,2020,43(06):564-570.

WANG Ying, ZHOU Jia. Association between human epidermal growth factor receptor-2 expression and prognosis of non-small cell lung cancer:Systematic review. [J]. Journal of Southwest Medical University 43(6):564-570(2020)
[1]王英,周佳.Her-2表达与非小细胞肺癌预后关系的系统评价[J].西南医科大学学报,2020,43(06):564-570. DOI：

WANG Ying, ZHOU Jia. Association between human epidermal growth factor receptor-2 expression and prognosis of non-small cell lung cancer:Systematic review. [J]. Journal of Southwest Medical University 43(6):564-570(2020) DOI：

摘要

目的:系统评价人类表皮因子生长受体2（human epidermal growth factor receptor 2

Her-2）与非小细胞肺癌（non small cell lung cancer

NSCLC）的预后关系。方法:通过检索Cochrane Library、EMbase、PubMed、知网等数据库

筛选Her-2与NSCLC预后的相关研究

采用纽卡斯尔-渥太华量表（Newcastle-ottawa cale

NOS）进行偏倚风险评估

Revman 5.3及Stata15.1软件进行统计分析。结果:共纳入20篇历史性队列研究

NOS评分均大于6分

病例总数为6199例

纳入研究异质性较小（I

=33%）

采用固定效应模型合并后HR=2.14（95%CI:1.85-2.47

0.00001）

提示Her-2过表达与NSCLC患者预后较差相关。亚组分析发现在不同分期及不同组织类型中

Her-2过表达均与NSCLC预后相关。Begg秩相关法提示不存在明显发表偏倚。结论:Her-2过表达与NSCLC预后不良存在关联

在不同的分期及组织类型中均提示其相关性。由于纳入文献主要为历史性队列研究

因此需要更多的前瞻性队列研究进一步验证。

Abstract

Objective:To systematically evaluate the association of human epidermal growth factor receptor-2（Her-2）with the prognosis of non-small cell lung cancer（NSCLC）.Methods:Related databases including Cochrane Library

EMbase

PubMed

and CNKI were searched for the studies on Her-2 and the prognosis of NSCLC.Newcastle-Ottawa Scale（NOS）was used to assess the risk of bias

and Revman5.3 and Stata15.1 software were used for statistical analysis.Results:A total of 20 historical cohort studies were included

with an NOS score of

and there were 6199 cases in total.The studies included had relatively low heterogeneity（I

= 33%）

and the pooled analysis with the fixed effects model showed a hazard ratio of 2.14（95% confidence interval:1.85 ～ 2.47

0.000 01）

suggesting that Her-2 overexpression was associated with the poor prognosis of NSCLC patients.The subgroup analysis showed that Her-2 overexpression was associated with the prognosis of NSCLC in patients with different stages or tissue types.The Begg rank correlation test showed no obvious publication bias.Conclusion:Her-2 overexpression is associated with the poor prognosis of NSCLC

which is indicated in different stages and tissue types.Since the articles included are mainly historical cohort studies

more prospective cohort studies are needed for further validation.

关键词

Her-2非小细胞肺癌预后系统评价

Keywords

Human epidermal growth factor receptor-2Non-small cell lung cancerPrognosisSystematic review

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