We report a case of Hunt syndrome with multiple cranial nerve involvement

who was treated with ultrasound-guided nerve block

and make a literature review on the treatment of Hunt syndrome. The patient

a 65-year-old man

was admitted to the hospital complaining of pain in his left ear

periauricular region

left face

and throat for 10 days. The pain was of neuropathic features of burning feeling and tenderness（neuropathic pain）. He also presented with vertigo

left peripheral facial paralysis

and superficial hypoesthesia of the regions innervated by the trigeminal nerve

glossopharyngeal nerve

and peripheral nerves of the upper cervical cord（C1-3）. The imaging examination showed left otitis media and mastoiditis and swelling of the base of left auricle. The patient was treated with ultrasound-guided block of the facial nerve

pterygopalatine ganglion

cervical facet joints

and stellate ganglion

as well as antiviral and nerve-nourishing therapies. After treatment

he had significant alleviation of pain in the face

ear

and neck; after 1 month

there was no pain

but with slight facial paralysis; after 3 months

he recovered from facial paralysis and resumed daily work. In this paper

we not only describe this case

but also extend to review the relevant literature of Hunt syndrome

especially focusing on its treatment. In our opinion

ultrasound-guided nerve block shows promise in the treatment of Hunt syndrome.