环境因素与男性生殖损害研究进展与展望

夏彦恺; 陈卿

doi:10.16016/j.2097-0927.202302014

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环境因素与男性生殖损害研究进展与展望

专题报道：环境因素对男性生殖健康的影响及机制 | 更新时间：2026-01-09

- 环境因素与男性生殖损害研究进展与展望
- Progress and prospect of environmental factors and male reproductive damage
- 陆军军医大学学报 2023年45卷第9期页码：861-868
- 作者机构：
  
  1.211166 南京，南京医科大学生殖医学国家重点实验室，南京医科大学公共卫生学院
  2.400038 重庆，陆军军医大学(第三军医大学)军事预防医学系毒理学研究所，电磁辐射医学防护教育部重点实验室
- 作者简介：
  
  [夏彦恺，二级教授，博士生导师，国家重大人才计划特聘教授、国家优青、教育部新世纪优秀人才、江苏省杰青及多个创新团队带头人。环境与人类健康国家级国际联合研究中心副主任，生殖医学国家重点实验室和现代毒理学教育部重点实验室方向带头人。兼任国家卫生应急体系建设指导专家、国家食品安全风险评估专家委员会委员，入选中国学术影响力公共卫生与预防医学领域百强、妇产与生殖医学领域百强。担任中华预防医学会、中国医促会等多个学会的常务理事和分会副主委；国际暴露科学学会、亚洲出生队列联盟学术委员会委员。担任Environ Int、Food Chem Toxicol等期刊编委、副主编。先后主持国家重点研发计划，国家自然科学基金重点、国合、优青等十余项国家级项目。获国家科学技术进步奖二等奖、省部级科技进步奖一等奖。在Nat Genet、Environ Health Persp、Environ Sci Technol、Environ Int、J Hazard Mater等期刊以第一/通信作者发表论著100余篇。主要从事环境与健康方面的研究。E-mail: yankaixia@njmu.edu.cnXIA Yankai, E-mail: yankaixia@njmu.edu.cn
- 基金信息：
  
  国家重点研发计划项目(2022YFC2702900);国家自然科学基金重点项目(82130097)
- DOI：10.16016/j.2097-0927.202302014
  中图分类号： R698.2;R994.6
- 收稿：2023-02-02，
  
  修回：2023-02-25，
  
  纸质出版：2023-05-15
- 稿件说明：
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夏彦恺, 陈卿. 环境因素与男性生殖损害研究进展与展望[J]. 陆军军医大学学报, 2023,45(9):861-868.

Yankai XIA, Qing CHEN. Progress and prospect of environmental factors and male reproductive damage[J]. Journal of Army Medical University, 2023, 45(9): 861-868.
夏彦恺, 陈卿. 环境因素与男性生殖损害研究进展与展望[J]. 陆军军医大学学报, 2023,45(9):861-868. DOI： 10.16016/j.2097-0927.202302014.

Yankai XIA, Qing CHEN. Progress and prospect of environmental factors and male reproductive damage[J]. Journal of Army Medical University, 2023, 45(9): 861-868. DOI： 10.16016/j.2097-0927.202302014.

摘要

男性生殖损害是我国和国际面临的重大卫生健康挑战。环境因素是当前导致男性生殖损害的重要原因之一。识别这些环境因素，阐明其损伤机制并研发针对性的防治策略，对于维护男性生殖健康，提升国家人口安全具有重要意义。本文概述近期环境因素导致男性生殖损伤相关研究进展：在有害因素识别方面，电磁辐射、新兴环境污染物、新冠病毒等物理、化学和生物因素的男性生殖损害效应正逐步被认识；在生殖损害的发生机制方面，铁死亡、昼夜节律与生物钟、表观遗传与染色质特征以及肠道菌群介导的环境因素致男性生殖损害机制成为新的研究热点。未来本领域将紧跟环境变化新形势，借助基础理论研究新进展及多学科交叉融合，深入探索复杂暴露等关键问题，人群与实验室研究相结合推动研究成果向卫生防控实践转化。

Abstract

Male reproductive damage is a major health challenge China and the world are facing. Environmental factors are one of the most important causes of male reproductive damage. Identifying these environmental factors

elucidating their damage mechanisms and developing targeted prevention and control strategies are of great significances in maintenance of male reproductive health and improvement of national population security. In this article

we summarize the recent progress on male reproductive damage caused by environmental factors. In male-reproductive toxicity

physical

chemical and biological factors

including electromagnetic radiation

emerging environmental contaminants and corona virus disease 2019 (COVID-19)

etc.

hav

e been recently recognized. On the other hand

ferroptosis

circadian rhythm

circadian clock

epigenetics

chromatin characteristics

as well as microbiota have been noticed to play important roles in the mechanism of the damage caused by environmental factors. In the future

we should focus on the new challenges of environmental changes

make full use of the advances in basic research and interdisciplinary integration

profoundly explore the key issues such as combinative exposure

and promote the transformation of research results into health prevention and control practices by combining population and laboratory research.

关键词

Keywords

references

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