基于新型住宿方舱的弥散供氧对移居高原人员生理学效应的影响

冉庄; 陈郁; 谭超; 刘鑫源; 王伟帅; 孙徐川; 罗勇军

doi:10.16016/j.1000-5404.202010080

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基于新型住宿方舱的弥散供氧对移居高原人员生理学效应的影响

临床医学 | 更新时间：2026-01-09

- 基于新型住宿方舱的弥散供氧对移居高原人员生理学效应的影响
- Influence of diffuse oxygen supply on physiological effects in migrants in plateau: a study based on a new accommodation cabin
- 第三军医大学学报 2021年43卷第8期页码：707-714
- 作者机构：
  
  400038 重庆，陆军军医大学(第三军医大学)陆军卫勤训练基地军事医学地理学教研室
- 作者简介：
  
  [罗勇军，E-mail: ajun-333333@163.com LUO Yongjun, E-mail: ajun-333333@163.com
- 基金信息：
  
  国家重点研发计划项目(2017YFC0806300);陆军军医大学科技创新能力提升专项项目(2019XYY09);国家科技部第二次青藏高原综合科学考察研究专题(2019QZKK0607)
- DOI：10.16016/j.1000-5404.202010080
  中图分类号： R339.54;R459.6;R852.14
- 收稿：2020-10-15，
  
  修回：2021-02-08，
  
  纸质出版：2021-04-30
- 稿件说明：
移动端阅览
冉庄, 陈郁, 谭超, 等. 基于新型住宿方舱的弥散供氧对移居高原人员生理学效应的影响[J]. 第三军医大学学报, 2021,43(8):707-714.

Zhuang RAN, Yu CHEN, Chao TAN, et al. Influence of diffuse oxygen supply on physiological effects in migrants in plateau: a study based on a new accommodation cabin[J]. Journal of Third Military Medical University, 2021, 43(8): 707-714.
冉庄, 陈郁, 谭超, 等. 基于新型住宿方舱的弥散供氧对移居高原人员生理学效应的影响[J]. 第三军医大学学报, 2021,43(8):707-714. DOI： 10.16016/j.1000-5404.202010080.

Zhuang RAN, Yu CHEN, Chao TAN, et al. Influence of diffuse oxygen supply on physiological effects in migrants in plateau: a study based on a new accommodation cabin[J]. Journal of Third Military Medical University, 2021, 43(8): 707-714. DOI： 10.16016/j.1000-5404.202010080.

摘要

目的

研究弥散吸氧对移居高原人员缺氧应激、血氧饱和度以及人体代谢过程的影响，阐明新型供氧方式的抗缺氧作用及其可能的分子机制。

方法

以移居海拔3 540 m高原某地1年以上的10名高原人员为研究对象，以新研发的弥散供氧住宿方舱为实验场所，研究对象在住宿方舱内连续弥散吸氧3 d，2 h/d。采用自身对照研究方法，检测研究对象吸氧前后生理指标、血常规指标及血浆代谢谱的变化。

结果

① 研究对象在住宿方舱内弥散吸氧期间，第1天舱内氧浓度为(22.85±0.36)%、第2天为(22.52±0.76)%、第3天为(22.57±1.05)%。②研究对象吸氧后血氧饱和度显著提高、脉率明显下降(

0.01)；血压吸氧前后比较差异无统计学意义。③研究对象吸氧后共有44种代谢物发生了显著改变(VIP＞1，

0.05)。其中，正离子模式下鉴定出18种，负离子模式下鉴定出26种。发现主要有4条代谢通路发生了明显变化[impact＞0.05，-log

(

)＞1.3

]

。

结论

通过弥散供氧方式吸氧能显著提高机体的心肺供氧能力，有效缓解高原缺氧寒冷环境对人体代谢的影响。

Abstract

Objective

To determine the effects of diffuse oxygen inhalation on hypoxia stress

blood oxygen saturation and human metabolic process in migrants in plateau

and to illustrate the anti-hypoxia effect of a new oxygen supply mode and its possible molecular mechanism.

Methods

Ten workers who had migrated to a plateau at an altitude of 3 540 m for more than 1 year were recruited as the subjects. They were asked to breathe oxygen in a newly developed accommodation cabin with diffuse oxygen supply for 3 consecutive days

2 h per day. Their physiological indexes

blood routine indexes and plasma metabolic profiles before and after oxygen intake were measured and compared.

Results

① The oxygen concentration was (22.85±0.36)% on the first day

(22.52±0.76)% on the second day and (22.57±1.05)% on the third day during the diffusion oxygen inhalation in the accommodation cabin. ②The oxygen saturation level and pulse rate were significantly increased after oxygen inhalation in the subjects (

0.01)

but there was no significant change in blood pressure (

0.05). ③ There were 44 metabolites significantly changed (VIP

0.05). Among them

18 metabolites were identified in the positive ion mode and 27 in the negative ion mode. And 4 major metabolic pathways also had significant changes [impact

0.05

-log

(

)

1.3

]

Conclusion

Oxygen inhalation

via

diffuse oxygen supply can effectively improve the capacity of cardiopulmonary oxygen supply

and alleviate the impact of hypoxia and cold environment on human metabolism.

关键词

Keywords

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