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400038 重庆, 陆军军医大学(第三军医大学)基础医学院生理学教研室,脑与智能研究院
[ "胡志安,博士,教授,博士研究生导师。陆军军医大学基础医学院生理学教研室主任,脑与智能研究院执行院长。担任中国睡眠研究会副理事长和中国神经科学会常务理事。为国家自然科学基金创新群体牵头人,主持国家重点基础研究发展计划(973计划)子课题、军委科技委国防科技创新特区重点项目、陆军军医大学军事医学创新预研基金重点项目等项目4项。获得中国人民解放军院校育才奖金奖、原中国人民解放军总后勤部优秀教师及重庆市道德模范标兵等荣誉。以通信作者在Science、Journal of Neuroscience、Cerebral Cortex(3篇)、Progress in Neurobiology等SCI收录的重要国际期刊上发表论著50余篇。主要从事觉醒睡眠方面的研究。E-mail:zhianhu@aliyun.com" ]
[ "何超,博士,副教授,硕士研究生导师。第三届中国科协青年人才托举工程入选者。主要从事觉醒睡眠与学习记忆方面的研究。E-mail:hechaochongqing@163.com" ]
收稿:2020-01-22,
修回:2020-02-05,
纸质出版:2020-03-15
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胡志安, 何超. 2019年中国脑科学研究进展[J]. 第三军医大学学报, 2020,42(5):431-436.
Zhi HU, Chao HE. Progress in brain science in China during 2019[J]. Journal of Third Military Medical University, 2020, 42(5): 431-436.
胡志安, 何超. 2019年中国脑科学研究进展[J]. 第三军医大学学报, 2020,42(5):431-436. DOI: 10.16016/j.1000-5404.202001185.
Zhi HU, Chao HE. Progress in brain science in China during 2019[J]. Journal of Third Military Medical University, 2020, 42(5): 431-436. DOI: 10.16016/j.1000-5404.202001185.
脑是人体最为复杂的器官,揭示脑的奥秘被认为是生命科学研究的“终极疆域”。迄今,脑科学研究在微观和宏观层面上已取得了一系列重大进展。中国科学家也为脑科学的发展做出了积极的贡献。在过去1年里,中国神经科学家在以下几个方面取得了重要成果:①脑功能原理,如进一步揭示了捕食、防御等本能行为的神经环路机制;②脑疾病的发病机制与诊治,如抑郁症、焦虑症、社交障碍的发病机制,亨廷顿病潜在的新疗法;③新技术、新材料的开发与应用,如新型去甲肾上腺素神经递质探针的开发,应用新型纳米材料使小鼠获得红外光感知能力。本文遴选了其中具有代表性的工作,并对其进行介绍。
Brain is the most complex organ in human body
and revealing its mystery is considered as the "ultimate territory" in biological science research. Till now
a series of significant progress has been made in the brain science research at the micro and macro levels. Chinese scientists have also made positive contributions to the development of the brain science. In the past year
Chinese scientists have made important achievements in the following aspects: ① the principle of brain functions
such as further revealing the circuitry mechanisms of predatory
defensive and other instinctive behaviors; ② the pathogenesis
diagnosis and treatment of brain diseases
such as the pathogenesis of depression
anxiety
social disorder and the potential new treatment of Huntington's disease; ③ the development and application of new technologies and materials
such as the development of norepinephrine neurotransmitter probe and the application of new nanomaterials that enables mice to obtain infrared light perception. In this article
the representative works are selected and introduced.
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ZHAO Z D, CHEN Z M, XIANG X K, et al . Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive driv e to promote hunting[J ] . Nat Neuro -sci, 2019, 22(6): 921-932. DOI:10.1038/s41593-019-0404-5.
ZHOU Z, LIU X, CHEN S, et al .A VTA GABAergic neural circuit mediates visually evoked innate defensive responses[J ] . Neuron, 2019, 103(3):473-488.e6. DOI: 10.1016/j.neuron.2019.05.027.
DONG P, WANG H, SHEN X F, et al . A novel cortico-intrathalamic circuit for flight behavior[J ] . Nat Neurosci, 2019, 22(6): 941-949. DOI: 10.1038/s41593-019-0391-6.
SHEN C J, ZHENG D, LI K X, et al . Cannabinoid CB1 receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbens modulate depressive-like behavior[J ] . Nat Med, 2019, 25(2): 337-349. DOI:10.1038/s41591-018-0299-9.
ZHOU W, JIN Y, MENG Q, et al . A neural circuit for comorbid depressive symptoms in chronic pain[J ] . Nat Neurosci, 2019, 22(10): 1649-1658. DOI: 10.1038/s41593-019-0468-2.
HUANG L, XI Y, PENG Y F, et al . A visual circuit related to habenula underlies the antidepressive effects of light therapy[J ] . Neuron, 2019, 102(1): 128-142.e8. DOI: 10.1016/j.neuron.2019.01.037.
FAN K Q, LI Y Y, WANG H L, et al . Stress-induced metabolic disorder in peripheral CD4+ T cells leads to anxiety-like behavior[J ] . Cell, 2019, 179(4): 864-879.e19. DOI: 10.1016/j.cell.2019.10.001.
SHAO L X, JIANG Q, LIU X X, et al . Functional coupling of Tmem74 and HCN1 channels regulates anxiety-like behavior in BLA neurons[J ] . Mol Psychiatry, 2019, 24(10): 1461-1477. DOI:10.1038/s41380-019-0402-8.
GUO B, CHEN J, CHEN Q, et al .Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice[J ] . Nat Neurosci, 2019, 22(8):1223-1234. DOI: 10.1038/s41593-019-0445-9.
XU H F, LIU L, TIAN Y Y, et al . A disinhibitory microcircuit mediates conditioned social fear in the prefrontal cortex[J ] . Neuron, 2019, 102(3): 668-682.e5. DOI:10.1016/j.neuron.2019.02.026.
LI Y, LI C Y, XI W, et al . Rostral and caudal ventral tegmental area GABAergic inputs to different dorsal raphe neurons participate in opioid dependence[J ] . Neuron, 2019, 101(4): 748-761.e5. DOI: 10.1016/j.neuron.2018.12.012.
ZHOU Y M, ZHU H W, LIU Z Y, et al . A ventral CA1 to nucleus accumbens core engram circuit mediates conditioned place preference for cocaine[J ] . Nat Neurosci, 2019, 22(12): 1986-1999. DOI:10.1038/s41593-019-0524-y.
SONG J, SHAO D, GUO X, et al . Crucial role of feedback signals from prelimbic cortex to basolateral amygdala in the retrieval of morphine withdrawal memory[J ] . Sci Adv, 2019, 5: eaat3210.
SU X Y, CHEN M, YUAN Y, et al . Central processing of itch in the midbrain reward center[J ] . Neuron, 2019, 102(4): 858-872.e5. DOI: 10.1016/j.neuron.2019.03.030.
LI Z, WANG C, WANG Z, et al .Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds[J ] . Nature, 2019, 575(7781): 203-209. DOI: 10.1038/s41586-019-1722-1.
FENG J, ZHANG C, LISCHINSKY J E, et al . A genetically encoded fluorescent sensor for rapid and specific in vivo detection of norepinephrine[J ] . Neuron, 2019, 102(4): 745-761.e8. DOI: 10.1016/j.neuron.2019.02.037..
SUN Q T, LI X N, REN M, et al . A whole-brain map of long-range inputs to GABAergic interneurons in the mouse medial prefrontal cortex[J ] . Nat Neurosci, 2019, 22(8): 1357-1370. DOI: 10.1038/s41593-019-0429-9.
MA Y Q, BAO J, ZHANG Y W, et al . Mammalian near-infrared image vision through injectable and self-powered retinal nanoantennae[J ] . Cell, 2019, 177(2): 243-255.e15. DOI:10.1016/j.cell.2019.01.038.
COOK S J, JARRELL T A, BRITTIN C A, et al .Whole-animal connectomes of both Caenorhabditis elegans sexes[J ] . Nature, 2019, 571(7763):63-71. DOI: 10.1038/s41586-019-1352-7.
MARQUES J C, LI M, SCHAAK D, et al . Internal state dynamics shape brainwide activity and foraging behaviour[J ] . Nature, 2020, 577(7789): 239-243. DOI:10.1038/s41586-019-1858-z.
LUKOWSKI S W, LO C Y, SHAROV A A, et al . A single-cell transcriptome atlas of the adult human retina[J ] . EMBO J, 2019, 38(18): e100811. DOI: 10.15252/embj.2018100811.
MOFFITT J R, BAMBAH-MUKKU D, EICHHORN S W, et al . Molecul ar, spatial, and functional single-cell profiling of the hypothalamic preoptic region[J ] . Science, 2018, 362(6416): eaau5324. DOI:10.1126/science.aau5324.
ZHONG S J, ZHANG S, FAN X Y, et al . A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex[J ] . Nature, 2018, 555(7697): 524-528. DOI:10.1038/nature25980.
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