Objective:To evaluate the effect and the significance of combined treatment for severe acute pancreatitis in ICU.Methods:96 cases of severe acute pancreatitis treated in ICU of the hospital where the authors worked from Jan.1996 to Jun.2004 were analyzed retrospectively.Results:GroupⅠwere treated with routine methods.14 patients died and the mortality was 31.8%(14/44).Group Ⅱwere treated with routine methods combined with continuous renal replacement therapy(CRRT).5 patients were treated with CRRT twice.26 patients were treated with emergent endoscopic retrograde cholangiopancreatography(ERCP)

endoscopic sphincterotomy(EST) and endoscopic naso-bile drainage(ENBD).32 patients were treated with the mechanical ventilation.46 patients were cured and 6 patients died. The mortality was 11.5%(6/52).Conclusion:The combined treatment in ICU can increase the curative effect of the severe acute pancreatitis.