Objective:According to the sensitivity of endobiliary biopsy during PTCD

to evaluate its pathologic foundation and clinical value for extrabiliary malignant tumor.Methods:Consecutive 102 patients with malignant obstructive jaundice were performed percutaneous transhepatic cholangiodrainage(PTCD)

forceps biopsy and brush cytology were manipulated during the procedure to confirm the nature of bile duct stenosis.27 cases were confirmed as extrabiliary malignant tumor which induced bile duct stricture.All the imaging and clinical data were retrospectively analyze.The positive result of biopsy was regarded as true-positive

while negative result can not exlude the existence of malignant tumor.According to the sensitivity of biopsy for malinant tumor

the pathologic foundation of bile duct stenosis was disscused and the clinical value of technique was avaluated.Chi-Square test was adopted to analyze the result of forceps biopsy and brushing

a P value of 0.05 or less was consided to indicate a significant difference.Results:Of all 27 patients with obstructivejaundice caused by extrabiliary malignant tumor

the sensitivity of endobiliary forceps was 88.9%

similar with that in literatures.The sensitivity of endobiliary forceps biopsy and brushing was 77.8% and 74.1%

respectively

the difference was not significence(P>0.05).Conclusion:Infiltrating throuth the wall of bile duct and into biliary lumen is the pathologic foundation for extrabiliary malignant tumor inducing bile duct stenosis.