Objective:To explore the efficacy and mechanism of continuous veno-venous hemofiltration in treatment of severe acute pancreatitis(SAP).Methods:21 consecutive patients with SAP were included in this study.They were administrated with central venous catheteration.AV600 hemofilter(1.4m~2) was applied for CVVH.CVVH was started 2.8±1.4 days after onset of disease and sustained for 44.6±30.7 hours.We monitored the changes of symptorm

physical sign

laboratory examination and cytokines during CVVH.Results:The hemodynamic state in all patients was stable during CVVH.The overall surviral rate in ICU reached to 76.2%.After implement of the CVVH treatment

abdominal pain and abdominal distension were considerably improved.Temperature

heart rate

breath rate decreased significantly

as well as serum concentrations of BUN

Cr

ALT

ALP

AMY

LPS declined.There was a considerable reduction in cytokines including TNF-α

IL-6

γ-INF at the end of CVVH treatment.Conclusion:CVVH is an effective therapeutic option in treatment of SAP.The early clearance of inflammatory mediators including TNF-α

IL-6

and γ-INF is thought to be an important mechanism for improving outcome.