骨原发性恶性纤维组织细胞瘤21例光镜、电镜、组化和免疫组化研究

向理科; 程德成; 李圆圆; 唐宜; 徐元浩

doi:10.13406/j.cnki.cyxb.2000.03.002

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骨原发性恶性纤维组织细胞瘤21例光镜、电镜、组化和免疫组化研究

更新时间：2024-01-17

- 骨原发性恶性纤维组织细胞瘤21例光镜、电镜、组化和免疫组化研究
- Primary malignant fibrous histiocytoma (MFH) of bone-A microscopical, ultrastructural,histochemical and immunohistochemical study of 21 cases
- 重庆医科大学学报 2000年第3期页码：228-230
- 作者机构：
  
  重庆医科大学基础医学院病理学教研室,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2000.03.002
  中图分类号： R738.1
- 纸质出版日期：2000，
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[1]向理科,程德成,李圆圆,唐宜,徐元浩.骨原发性恶性纤维组织细胞瘤21例光镜、电镜、组化和免疫组化研究[J].重庆医科大学学报,2000(03):228-230.

Primary malignant fibrous histiocytoma (MFH) of bone-A microscopical, ultrastructural,histochemical and immunohistochemical study of 21 cases[J]. Journal of Chongqing Medical University, 2000,(3):228-230.
[1]向理科,程德成,李圆圆,唐宜,徐元浩.骨原发性恶性纤维组织细胞瘤21例光镜、电镜、组化和免疫组化研究[J].重庆医科大学学报,2000(03):228-230. DOI： 10.13406/j.cnki.cyxb.2000.03.002.

Primary malignant fibrous histiocytoma (MFH) of bone-A microscopical, ultrastructural,histochemical and immunohistochemical study of 21 cases[J]. Journal of Chongqing Medical University, 2000,(3):228-230. DOI： 10.13406/j.cnki.cyxb.2000.03.002.

摘要

目的探讨骨原发性恶性纤维组织细胞瘤（ＭＦＨ）的形态特征和组织发生。方法应用光镜、电镜观察骨ＭＦＨ的组织学结构和细胞形态；应用组织化学和免疫组织化学检测２１例骨ＭＦＨ中非特异性酯酶（ＡＮＡＥ），酸性磷酸酶（ＡＣＰ）的酶活性和α１－抗胰蛋白酶（α１－ＡＴ）、α１－抗胰糜蛋白酶（α１－ＡＣＴ）、ＣＤ６８、波形蛋白（Ｖｉｍｅｎｔｉｎ）、神经特异性烯醇化酶（ＮＳＥ）、嗜铬素Ａ（ＣｇＡ）和突触素（ＳＹ）的表达水平。结果骨原发性ＭＦＨ由多种细胞成分组成，组织化学和免疫组织化学染色证实瘤细胞具有组织细胞或成纤维细胞特征。其中３例电镜观察到部分瘤细胞内有神经内分泌颗粒，这些细胞对ＮＳＥ、ＣｇＡ、ＳＹ阳性表达率分别为２０％、１８％、１５％。结论我们研究结果支持骨原发性ＭＦＨ起源于原始间叶细胞，并指出骨ＭＦＨ少数瘤细胞可能伴有神经内分泌分化，同时对诊断和鉴别诊断进行了讨论。

Abstract

Objective To study the histiogenesis and morphological features of primary malignant fibrous histiocytoma(MFH)of bone. Methods The microscopic and ultrastructural techniques were used to observe the histologic structure and cytomorphology of bone MFH. Histochemical and immunohistochemical stainings were used to determine the expression of ANAE

ACP

α1-AT

α1 -ACT

CD68

vimentin

NSE

CgA and SY in 21 bone MFH. Results The results of study confirmed that bone MFH was composed of an admixture of various types of tumor cells; the histiocytes and fibroblasts were evidenced by ANAE

ACP

α1-AT

α1-ACT

CD68 and vimentin. Neuroendocrine cells by EM in 3 cases were demonstrated by NSE

CgA and SY. The positive cells were 20%

18% and 15% respectively. Conclusion Our study supports the concept that bone MFH arise from primative mesenchymal cells that are probable of differentiating toward different lines

including neuroendocrine cells. Diagnosis and differential diagnosis of bone MFH were also discussed.

关键词

骨肿瘤恶性纤维组织细胞瘤超微结构免疫组织化学

Keywords

Bone neoplasmsMalignant fibrous histiocytomaultrastructureLmmunohistochemistry

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