Strategies to prevent hypertrophic scar formation: a review of therapeutic interventions based on molecular evidence

Eri Shirakami; Sho Yamakawa; Kenji Hayashida

doi:10.1093/burnst/tkz003

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Strategies to prevent hypertrophic scar formation: a review of therapeutic interventions based on molecular evidence

更新时间：2022-06-09

- Strategies to prevent hypertrophic scar formation: a review of therapeutic interventions based on molecular evidence
- Strategies to prevent hypertrophic scar formation: a review of therapeutic interventions based on molecular evidence
- Burns & Trauma 2020年8卷第1期
- 作者机构：
  
  Division of Plastic and Reconstructive Surgery
- 作者简介：
- 基金信息：
  
  The authors declare that there are no financial disclosures.
- DOI：10.1093/burnst/tkz003
  中图分类号：
- 纸质出版日期：2020，
  
  网络出版日期：2020-1-27，
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Eri Shirakami, Sho Yamakawa, Kenji Hayashida. Strategies to prevent hypertrophic scar formation: a review of therapeutic interventions based on molecular evidence[J]. Burns & Trauma, 2020,8(1).

Eri Shirakami, Sho Yamakawa, Kenji Hayashida, Strategies to prevent hypertrophic scar formation: a review of therapeutic interventions based on molecular evidence, Burns & Trauma, Volume 8, 2020, tkz003, https://doi.org/10.1093/burnst/tkz003
Eri Shirakami, Sho Yamakawa, Kenji Hayashida. Strategies to prevent hypertrophic scar formation: a review of therapeutic interventions based on molecular evidence[J]. Burns & Trauma, 2020,8(1). DOI： 10.1093/burnst/tkz003.

Eri Shirakami, Sho Yamakawa, Kenji Hayashida, Strategies to prevent hypertrophic scar formation: a review of therapeutic interventions based on molecular evidence, Burns & Trauma, Volume 8, 2020, tkz003, https://doi.org/10.1093/burnst/tkz003 DOI：

摘要

Abstract

Once scar tissues mature

it is impossible for the surrounding tissue to regenerate normal dermal tissue. Therefore

it is essential to understand the fundamental mechanisms and establish effective strategies to inhibit aberrant scar formation. Hypertrophic scar formation is considered a result of the imbalance between extracellular matrix synthesis and degradation during wound healing. However

the underlying mechanisms of hypertrophic scar development are poorly understood. The purpose of this review was to outline the management in the early stage after wound healing to prevent hypertrophic scar formation

focusing on strategies excluding therapeutic agents of internal use. Treatment aimed at molecular targets

including cytokines

will be future options to prevent and treat hypertrophic scars. More basic studies and clinical trials

including combination therapy

are required to investigate the mechanisms and prevent hypertrophic scar formation.

关键词

Keywords

Hypertrophic scarTherapyInterventionCytokines

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