Autophagy-mediated regulation of neutrophils and clinical applications

Yao Yu; Bingwei Sun

doi:10.1093/burnst/tkz001

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Autophagy-mediated regulation of neutrophils and clinical applications

更新时间：2022-06-09

- Autophagy-mediated regulation of neutrophils and clinical applications
- Autophagy-mediated regulation of neutrophils and clinical applications
- Burns & Trauma 2020年8卷第1期
- 作者机构：
  
  Department of Burns and Plastic Surgery
- 作者简介：
- 基金信息：
  
  This study was supported by the National Natural Science Foundation of China (No. 81772135 and No. 81471903) and the Jiangsu Natural Science Foundation (No. BE2017695).
- DOI：10.1093/burnst/tkz001
  中图分类号：
- 纸质出版日期：2020，
  
  网络出版日期：2020-1-16，
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Yao Yu, Bingwei Sun. Autophagy-mediated regulation of neutrophils and clinical applications[J]. Burns & Trauma, 2020,8(1).

Yao Yu, Bingwei Sun, Autophagy-mediated regulation of neutrophils and clinical applications, Burns & Trauma, Volume 8, 2020, tkz001, https://doi.org/10.1093/burnst/tkz001
Yao Yu, Bingwei Sun. Autophagy-mediated regulation of neutrophils and clinical applications[J]. Burns & Trauma, 2020,8(1). DOI： 10.1093/burnst/tkz001.

Yao Yu, Bingwei Sun, Autophagy-mediated regulation of neutrophils and clinical applications, Burns & Trauma, Volume 8, 2020, tkz001, https://doi.org/10.1093/burnst/tkz001 DOI：

摘要

Abstract

Autophagy

an adaptive catabolic process

plays a cytoprotective role in enabling cellular homeostasis in the innate and adaptive immune systems. Neutrophils

the most abundant immune cells in circulation

are professional killers that orchestrate a series of events during acute inflammation. The recent literature indicates that autophagy has important roles in regulating neutrophil functions

including differentiation

degranulation

metabolism and neutrophil extracellular trap formation

that dictate neutrophil fate. It is also becoming increasingly clear that autophagy regulation is critical for neutrophils to exert their immunological activity. However

evidence regarding the systematic communication between neutrophils and autophagy is insufficient. Here

we provide an updated overview of the function of autophagy as a regulator of neutrophils and discuss its clinical relevance to provide novel insight into potentially relevant treatment strategies.

关键词

Keywords

AutophagyNeutrophilInnate immunityNETsClinical applicationNeutrophil extracellular trap

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