The impact of burn injury on the central nervous system

Amira Allahham; Grant Rowe; Andrew Stevenson; Mark W Fear; Ann-Maree Vallence; Fiona M Wood

doi:10.1093/burnst/tkad037

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The impact of burn injury on the central nervous system

更新时间：2024-04-19

- The impact of burn injury on the central nervous system
- The impact of burn injury on the central nervous system
- Burns & Trauma 2024年12卷第1期
- 作者机构：
  
  1. Burn injury research unit, School of Biomedical Sciences, University of Western Australia
  2. Fiona Wood Foundation
  3. Centre for Molecular Medicine and Innovative Therapeutics
  4. Centre for Healthy Ageing
  5. Murdoch University
  6. Burn Service of Western Australia
  7. School of Psychology, College of Health and Education, Murdoch University
- 作者简介：
- 基金信息：
  
  AA is funded by the University of Western Australia’s RTP Stipend scholarship, AS is funded by the University of Western Australia, MWF is funded by the Stan Perron Centre of Excellence for Childhood Burns and the Perth Children’s Hospital Foundation, FMW is funded by the WA Department of Health.
- DOI：10.1093/burnst/tkad037
  中图分类号：
- 纸质出版日期：2024，
  
  网络出版日期：2024-2-1，
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Amira Allahham, Grant Rowe, Andrew Stevenson, 等. The impact of burn injury on the central nervous system[J]. Burns & Trauma, 2024,12(1).

Amira Allahham, Grant Rowe, Andrew Stevenson, Mark W Fear, Ann-Maree Vallence, Fiona M Wood, The impact of burn injury on the central nervous system, Burns & Trauma, Volume 12, 2024, tkad037, https://doi.org/10.1093/burnst/tkad037
Amira Allahham, Grant Rowe, Andrew Stevenson, 等. The impact of burn injury on the central nervous system[J]. Burns & Trauma, 2024,12(1). DOI： 10.1093/burnst/tkad037.

Amira Allahham, Grant Rowe, Andrew Stevenson, Mark W Fear, Ann-Maree Vallence, Fiona M Wood, The impact of burn injury on the central nervous system, Burns & Trauma, Volume 12, 2024, tkad037, https://doi.org/10.1093/burnst/tkad037 DOI：

摘要

Abstract

Burn injuries can be devastating

with life-long impacts including an increased risk of hospitalization for a wide range of secondary morbidities. One area that remains not fully understood is the impact of burn trauma on the central nervous system (CNS). This review will outline the current findings on the physiological impact that burns have on the CNS and how this may contribute to the development of neural comorbidities including mental health conditions. This review highlights the damaging effects caused by burn injuries on the CNS

characterized by changes to metabolism

molecular damage to cells and their organelles

and disturbance to sensory

motor and cognitive functions in the CNS. This damage is likely initiated by the inflammatory response that accompanies burn injury

and it is often long-lasting. Treatments used to relieve the symptoms of damage to the CNS due to burn injury often target inflammatory pathways. However

there are non-invasive treatments for burn patients that target the functional and cognitive damage caused by the burn

including transcranial magnetic stimulation and virtual reality. Future research should focus on understanding the mechanisms that underpin the impact of a burn injury on the CNS

burn severity thresholds required to inflict damage to the CNS

and acute and long-term therapies to ameliorate deleterious CNS changes after a burn.

关键词

Keywords

BurnInjuryCentral nervous systemBrainSpinal cordInflammation

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