Cell electrospinning and its application in wound healing: principles, techniques and prospects

Zonghao Hu; Zishun Qin; Yue Qu; Feng Wang; Benheng Huang; Gaigai Chen; Xiaoyuan Liu; Lihua Yin

doi:10.1093/burnst/tkad028

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Cell electrospinning and its application in wound healing: principles, techniques and prospects

更新时间：2024-02-04

- Cell electrospinning and its application in wound healing: principles, techniques and prospects
- Cell electrospinning and its application in wound healing: principles, techniques and prospects
- Burns & Trauma 2023年11卷第1期
- 作者机构：
  
  1. Department of Implantology
  2. Lanzhou University
  3. The First Clinical Medical College, Lanzhou University
- 作者简介：
- 基金信息：
  
  This research was supported by the Competitive Projects for Science and Technology Innovation and Development of Gansu Province (2018ZX-10), Gansu Provincial Key Research and Development Project-International Science and Technology Cooperation (22YF7WA013), Gansu Provincial Department of Science and Technology, Gansu Provincial Science and Technology Program (Nature Science Foundation)-Excellent Doctoral Program (22JR5RA893), Lanzhou Talent Innovation and Venture Project (2017-RC-31), CSA West China Clinical Research Fund (CSA-W2022-11), Clinical Research Project of Hospital of Stomatology Lanzhou University (lzukqky-2022-t06).
- DOI：10.1093/burnst/tkad028
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-9-15，
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Zonghao Hu, Zishun Qin, Yue Qu, 等. Cell electrospinning and its application in wound healing: principles, techniques and prospects[J]. Burns & Trauma, 2023,11(1).

Zonghao Hu, Zishun Qin, Yue Qu, Feng Wang, Benheng Huang, Gaigai Chen, Xiaoyuan Liu, Lihua Yin, Cell electrospinning and its application in wound healing: principles, techniques and prospects, Burns & Trauma, Volume 11, 2023, tkad028, https://doi.org/10.1093/burnst/tkad028
Zonghao Hu, Zishun Qin, Yue Qu, 等. Cell electrospinning and its application in wound healing: principles, techniques and prospects[J]. Burns & Trauma, 2023,11(1). DOI： 10.1093/burnst/tkad028.

Zonghao Hu, Zishun Qin, Yue Qu, Feng Wang, Benheng Huang, Gaigai Chen, Xiaoyuan Liu, Lihua Yin, Cell electrospinning and its application in wound healing: principles, techniques and prospects, Burns & Trauma, Volume 11, 2023, tkad028, https://doi.org/10.1093/burnst/tkad028 DOI：

摘要

Abstract

Currently

clinical strategies for the treatment of wounds are limited

especially in terms of achieving rapid wound healing. In recent years

based on the technique of electrospinning (ES)

cell electrospinning (C-ES) has been developed to better repair related tissues or organs (such as skin

fat and muscle) by encapsulating living cells in a microfiber or nanofiber environment and constructing 3D living fiber scaffolds. Therefore

C-ES has promising prospects for promoting wound healing. In this article

C-ES technology and its advantages

the differences between C-ES and traditional ES

the parameters suitable for maintaining cytoactivity

and material selection and design issues are summarized. In addition

we review the application of C-ES in the fields of biomaterials and cells. Finally

the limitations and improved methods of C-ES are discussed. In conclusion

the potential advantages

limitations and prospects of C-ES application in wound healing are presented.

关键词

Keywords

Cell electrospinningWound healingTissue regenerationWound repairBiomaterialTissue engineering

references

1.Farahani M, Shafiee A. Wound healing: from passive to smart dressings. Adv Healthc Mater 2021; 10: e2100477. https://doi.org/10.1002/adhm.202100477.

2.Gao C, Zhang L, Wang J, Jin M, Tang Q, Chen Z, et al. Electrospun nanofibers promote wound healing: theories, techniques, and perspectives. J Mater Chem B. 2021;9:3106–30.

3.Enoch S, Grey JE, Harding KG. Recent advances and emerging treatments. BMJ. 2006;332:962–5.

4.Bandyk DF. The diabetic foot: pathophysiology, evaluation, and treatment. Semin Vasc Surg. 2018;31:43–8.

5.Pazyar N, Yaghoobi R, Rafiee E, Mehrabian A, Feily A. Skin wound healing and phytomedicine: a review. Skin Pharmacol Physiol. 2014;27:303–10.

6.Krishnan R, Rajeswari R, Venugopal J, Sundarrajan S, Sridhar R, Shayanti M, et al. Polysaccharide nanofibrous scaffolds as a model for in vitro skin tissue regeneration. J Mater Sci Mater Med. 2012;23:1511–9.

7.Pereira RF, Barrias CC, Granja PL, Bartolo PJ. Advanced biofabrication strategies for skin regeneration and repair. Nanomedicine (Lond). 2013;8:603–21.

8.Xue J, Wu T, Dai Y, Xia Y. Electrospinning and electrospun nanofibers: methods, materials, and applications. Chem Rev. 2019;119:5298–415.

9.Zhang Y, Lim CT, Ramakrishna S, Huang ZM. Recent development of polymer nanofibers for biomedical and biotechnological applications. J Mater Sci Mater Med. 2005;16:933–46.

10.Townsend-Nicholson A, Jayasinghe SN. Cell electrospinning: a unique biotechnique for encapsulating living organisms for generating active biological microthreads/scaffolds. Biomacromolecules. 2006;7:3364–9.

11.Hong J, Yeo M, Yang GH, Kim G. Cell-electrospinning and its application for tissue engineering. Int J Mol Sci. 2019;20:6208. https://doi.org/10.3390/ijms20246208.

12.Qin S, Clark RA, Rafailovich MH. Establishing correlations in the en-mass migration of dermal fibroblasts on oriented fibrillar scaffolds. Acta Biomater. 2015;25:230–9.

13.Zhang P, Zou B, Liou YC, Huang C. The pathogenesis and diagnosis of sepsis post burn injury. Burns Trauma. 2021,9: tkaa047. https://doi.org/10.1093/burnst/tkaa047.

14.Pham QP, Sharma U, Mikos AG. Electrospinning of polymeric nanofibers for tissue engineering applications: a review. Tissue Eng. 2006;12:1197–211.

15.Chen H, Liu Y, Hu Q. A novel bioactive membrane by cell electrospinning. Exp Cell Res. 2015;338:261–6.

16.Yeo M, Kim GH. Anisotropically aligned cell-laden Nanofibrous bundle fabricated via cell electrospinning to regenerate skeletal muscle tissue. Small. 2018;14:e1803491. https://doi.org/10.1002/smll.201803491.

17.Bhardwaj N, Kundu SC. Electrospinning: a fascinating fiber fabrication technique. Biotechnol Adv. 2010;28:325–47.

18.Gupta, P, Elkins C, Long TE, Wilkes GL. Electrospinning of linear homopolymers of poly (methyl methacrylate): exploring relationships between fiber formation, viscosity, molecular weight and concentration in a good solvent. Polymer 2005; 46:4799–810. https://doi.org/10.1016/j.polymer.2005.04.021.

19.Demir M, Yilgor I, Yilgor E, Erman B. Electrospinning of polyurethane fibers. Polymer. 2002;43:3303–9.

20.Son W, Youk J, Lee T, Park W. The effects of solution properties and polyelectrolyte on electrospinning of ultrafine poly (ethylene oxide) fibers. Polymer. 2004;45:2959–66.

21.Jun Z, Hou H, Schaper A, Wendorff J, Greiner A. Poly-L-lactide nanofibers by electrospinning — influence of solution viscosity and electrical conductivity on fiber diameter and fiber morphologye. Polymer. 2003;9:1–9.

22.Gopinathan J, Noh I. Recent trends in bioinks for 3D printing. Biomater Res. 2018;22:11. https://doi.org/10.1186/s40824-018-0122-1.

23.Jiang H, Fang D, Hsiao B, Chu B, Chen W. Optimization and characterization of dextran membranes prepared by electrospinning. Biomacromolecules. 2004;5:326–33.

24.Zuo W, Zhu M, Yang W, Yu H, Chen Y, Zhang Y. Experimental study on relationship between jet instability and formation of beaded fibers during electrospinning. Polym Eng Sci. 2005;45:704–9.

25.Mit-uppatham C, Nithitanakul M, Supaphol P. Ultrafine electrospun polyamide-6 fibers: effect of solution conditions on morphology and average fiber diameter. Macromol Chem Phys. 2004;205:2327–38.

26.Yeo M, Kim G. Fabrication of cell-laden electrospun hybrid scaffolds of alginate-based bioink and PCL microstructures for tissue regeneration. Chem Eng J. 2015;275:27–35.

27.Ki C, Baek D, Gang K, Lee K, Um L, Park Y. Characterization of gelatin nanofiber prepared from gelatin-formic acid solution. Polymer. 2005;46:5094–102.

28.Reneker D, Yarin A, Fong H, Koombhongse S. Bending instability of electrically charged liquid jets of polymer solutions in electrospinning. J Appl Phys. 2000;87:4531–47.

29.Jayasinghe SN. Cell electrospinning: a novel tool for functionalising fibres, scaffolds and membranes with living cells and other advanced materials for regenerative biology and medicine. Analyst. 2013;138:2215–23.

30.Huang Z, Zhang Y, Kotaki M, Ramakrishna S. A review on polymer nanofibers by electrospinning and their applications in nanocomposites. ComposSciTechnol. 2003;63:2223–53.

31.Lee K, Kim H, Khil M, Ra Y, Lee D. Characterization of nano-structured poly (ε-caprolactone) nonwoven mats via electrospinning. Polymer. 2003;44:1287–94.

32.Zhao Y, Li Y, Mao S, Sun W, Yao R. The influence of printing parameters on cell survival rate and printability in microextrusion-based 3D cell printing technology. Biofabrication. 2015;7:045002. https://doi.org/10.1088/1758-5090/7/4/045002. https://doi.

33.Ouyang L, Yao R, Zhao Y, Sun W. Effect of bioink properties on printability and cell viability for 3D bioplotting of embryonic stem cells. Biofabrication. 2016;8:035020. https://doi.org/10.1088/1758-5090/8/3/035020.

34.Tripatanasuwan S, Zhong Z, Reneker D. Effect of evaporation and solidification of the charged jet in electrospinning of poly (ethylene oxide) aqueous solution. Polymer. 2007;48:5742–6.

35.Yarin A, Koombhongse S, Reneker D. Bending instability in electrospinning of nanofibers. J Appl Phys. 2001;89:3018–26.

36.Xu S, Lu T, Yang L, Luo S, Wang Z, Ye C. In situ cell electrospun using a portable handheld electrospinning apparatus for the repair of wound healing in rats. Int Wound J. 2022;19:1693–704.

37.Canbolat MF, Tang C, Bernacki SH, Pourdeyhimi B, Khan S. Mammalian cell viability in electrospun composite nanofiber structures. Macromol Biosci. 2011;11:1346–56.

38.Williams D, Thayer P, Martinez H, Gatenholm E, Khademhosseini A. A perspective on the physical, mechanical and biological specifications of bioinks and the development of functional tissues in 3D bioprinting. Bioprinting. 2018;9:19–36.

39.Kim Y, Lee H, Kim G. Strategy to achieve highly porous/biocompatible macroscale cell blocks, using a collagen/genipin-bioink and an optimal 3D printing process. ACS Appl Mater Interfaces. 2016;8:32230–40.

40.Ding B, Kim H, Lee S, Lee D, Choi K. Preparation and characterization of nanoscaled poly (vinyl alcohol) fibers via electrospinning. Fiber Polym. 2002;3:73–9.

41.Yang G, Li H, Yang J, Wan J, Yu D. Influence of working temperature on the formation of electrospun polymer nanofibers. Nanoscale Res Lett. 2017;12:55. https://doi.org/10.1186/s11671-016-1824-8.

42.Bonino C, Efimenko K, Jeong S, Krebs M, Alsberg E, Khan S. Three-dimensional electrospun alginate nanofiber mats via tailored charge repulsions. Small. 2012;8:1928–36.

43.Ehler E, Jayasinghe SN. Cell electrospinning cardiac patches for tissue engineering the heart. Analyst. 2014;139:4449–52.

44.Jayasinghe SN, Qureshi AN, Eagles PA. Electrohydrodynamic jet processing: an advanced electric-field-driven jetting phenomenon for processing living cells. Small. 2006;2:216–9.

45.Kempski H, Austin N, Roe A, Chatters S, Jayasinghe SN. Pilot study to investigate the possibility of cytogenetic and physiological changes in bio-electrosprayed human lymphocyte cells. Regen Med. 2008;3:343–9.

46.Bartolovic K, Mongkoldhumrongkul N, Waddington SN, Jayasinghe SN, Howe SJ. The differentiation and engraftment potential of mouse hematopoietic stem cells is maintained after bio-electrospray. Analyst. 2010;135:157–64.

47.Jayasinghe SN, Warnes G, Scotton CJ. Bio-electrosprayed living composite matrix implanted into mouse models. Macromol Biosci. 2011;11:1364–9.

48.Poncelet D, de Vos P, Suter N, Jayasinghe SN. Bio-electrospraying and cell electrospinning: progress and opportunities for basic biology and clinical sciences. Adv Healthc Mater. 2012;1:27–34.

49.Jayasinghe SN, Auguste J, Scotton CJ. Platform technologies for directly reconstructing 3D living biomaterials. Adv Mater. 2015;27:7794–9.

50.Zamani R, Aval SF, Pilehvar-Soltanahmadi Y, Nejati-Koshki K, Zarghami N. Recent dvances in cell Electrospining of natural and synthetic nanofibers for regenerative medicine. Drug Res (Stuttg). 2018;68:425–35.

51.Nosoudi N, Oommen AJ, Stultz S, Jordan M, Aldabel S, Hohne C, et al. Electrospinning live cells using gelatin and pullulan. Bioengineering (Basel). 2020;7:21. https://doi.org/10.3390/bioengineering7010021.

52.Stojanov S, Berlec A. Electrospun nanofibers as carriers of microorganisms, stem cells, proteins, and nucleic acids in therapeutic and other applications. Front Bioeng Biotechnol. 2020;8:130. https://doi.org/10.3389/fbioe.2020.00130.

53.Yeo M, Yoon JW, Park GT, Shin SC, Song YC, Cheon YI, et al. Esophageal wound healing by aligned smooth muscle cell-laden nanofibrous patch. Mater Today Bio. 2023;19:100564. https://doi.org/10.1016/j.mtbio.2023.100564.

54.Ferreira A, Gentile P, Chiono V, Ciardelli G. Collagen for bone tissue regeneration. Acta Biomater. 2012;8:3191–200.

55.Dong C, Lv Y. Application of collagen scaffold in tissue engineering: recent advances and new perspectives. Polymers (Basel). 2016;8:42. https://doi.org/10.3390/polym8020042.

56.Ross-Murphy S. Structure and rheology of gelatin gels: recent progress. Polym. 1992;33:2622–7.

57.Yeo M, Kim G. Micro/nano-hierarchical scaffold fabricated using a cell electrospinning/3D printing process for co-culturing myoblasts and HUVECs to induce myoblast alignment and differentiation. Acta Biomater. 2020;107:102–14.

58.Jayasinghe SN, Irvine S, McEwan JR. Cell electrospinning highly concentrated cellular suspensions containing primary living organisms into cell-bearing threads and scaffolds. Nanomedicine (Lond). 2007;2:555–67.

59.Patel P, Irvine S, McEwan JR, Jayasinghe SN. Bio-protocols for directly forming active encapsulations containing living primary cells. Soft Matter. 2008;4:1219–29.

60.Shih Y, Yang J, Li S, Yang W, Chen C. Bio-electrospinning of poly (l-lactic acid) hollow fibrous membrane. Text Res J. 2012;82:602–12.

61.Guo Y, Gilbert-Honick J, Somers SM, Mao HQ, Grayson WL. Modified cell-electrospinning for 3D myogenesis of C2C12s in aligned fibrin microfiber bundles. Biochem Biophys Res Commun. 2019;516:558–64.

62.Balagangadharan K, Dhivya S, Selvamurugan N. Chitosan based nanofibers in bone tissue engineering. Int J Biol Macromol. 2017;104:1372–82.

63.Augustine R, Rehman SR, Ahmed R, Zahid A, Sharifi M, Falahati M, et al. Electrospun chitosan membranes containing bioactive and therapeutic agents for enhanced wound healing. Int J Biol Macromol. 2020;156:153–70.

64.Litwiniuk M, Krejner A, Speyrer M, Gauto A, Grzela T. Hyaluronic acid in inflammation and tissue regeneration. Wounds. 2016;28:78–88.

65.Yang H, Song L, Zou Y, Sun D, Wang L, Yu Z, et al. Role of hyaluronic acids and potential as regenerative biomaterials in Wound healing. ACS Appl Bio Mater. 2021;4:311–24.

66.Farokhi M, Mottaghitalab F, Fatahi Y, Khademhosseini A, Kaplan DL. Overview of silk fibroin use in Wound dressings. Trends Biotechnol. 2018;36:907–22.

67.Kamalathevan P, Ooi P, Loo Y. Silk-based biomaterials in cutaneous Wound healing: a systematic review. Adv Skin Wound Care. 2018;31:565–73.

68.Zhang Q, Qiao Y, Li C, Lin J, Han H, Li X, et al. Chitosan/gelatin-tannic acid decorated porous tape suture with multifunctionality for tendon healing. Carbohydr Polym. 2021;268:118246. https://doi.org/10.1016/j.carbpol.2021.118246.

69. Zhou K, Zhang Z, Xue J, Shang J, Ding D, Zhang W, et al. Hybrid ag nanoparticles/polyoxometalate-polydopamine nano-flowers loaded chitosan/gelatin hydrogel scaffolds with synergistic photothermal/chemodynamic/ag anti-bacterial action for accelerated wound healing. Int J Biol Macromol. 2022;221:135–48.

70.Sakthiguru N, Sithique M. Fabrication of bioinspired chitosan/gelatin/allantoin biocomposite film for wound dressing application. Int J Biol Macromol. 2020;152:873–83.

71.Paskal M, Paskal W, Pietruski P, Wlodarski P. Polyethylene glycol: the future of posttraumatic nerve repair? Systemic review. Int J Mol Sci. 2019;20:1478. https://doi.org/10.3390/ijms20061478.

72.Zhang X, Yang D, Nie J. Chitosan/polyethylene glycol diacrylate films as potential wound dressing material. Int J Biol Macromol. 2008;43:456–62.

73.Heo DN, Yang DH, Lee JB, Bae MS, Kim JH, Moon SH, et al. Burn-wound healing effect of gelatin/polyurethane nanofiber scaffold containing silver-sulfadiazine. J Biomed Nanotechnol. 2013;9:511–5.

74.Kim SE, Heo DN, Lee JB, Kim JR, Park SH, Jeon SH, et al. Electrospun gelatin/polyurethane blended nanofibers for wound healing. Biomed Mater. 2009;4:044106. https://doi.org/10.1088/1748-6041/4/4/044106.

75.Zhang P, Jiang Y, Liu D, Liu Y, Ke Q, Xu H. A bioglass sustained-release scaffold with ECM-like structure for enhanced diabetic wound healing. Nanomedicine (Lond). 2020;15:2241–53.

76.Rajzer I, Dziadek M, Kurowska A, Cholewa-Kowalska K, Ziąbka M, Menaszek E, et al. Electrospun polycaprolactone membranes with Zn-doped bioglass for nasal tissues treatment. J Mater Sci Mater Med. 2019;30:80. https://doi.org/10.1007/s10856-019-6280-4.

77.Zhao W, Li J, Jin K, Liu W, Qiu X, Li C. Fabrication of functional PLGA-based electrospun scaffolds and their applications in biomedical engineering. Mater Sci Eng C Mater Biol Appl. 2016;59:1181–94.

78.Wu L, Li H, Li S, Li X, Yuan X, Li X, et al. Composite fibrous membranes of PLGA and chitosan prepared by coelectrospinning and coaxial electrospinning. J Biomed Mater Res A. 2010;92:563–74.

79.Zhong G, Qiu M, Zhang J, Jiang F, Yue X, Huang C, et al. Fabrication and characterization of PVA@PLA electrospinning nanofibers embedded with Bletilla striata polysaccharide and Rosmarinic acid to promote wound healing. Int J Biol Macromol. 2023;234:123693. https://doi.org/10.1016/j.ijbiomac.2023.123693.

80.Li L, Liu X, Niu Y, Ye J, Huang S, Liu C, et al. Synthesis and wound healing of alternating block polyurethanes based on poly(lactic acid) (PLA) and poly(ethylene glycol) (PEG). J Biomed Mater Res B Appl Biomater. 2017;105:1200–9.

81.Azari A, Golchin A, Mahmoodinia Maymand M, Mansouri F, Ardeshirylajimi A. Electrospun Polycaprolactone nanofibers: current research and applications in biomedical application. Adv Pharm Bull. 2022;12:658–72.

82.Croisier F, Atanasova G, Poumay Y, Jérôme C. Polysaccharide-coated PCL nanofibers for wound dressing applications. Adv Healthc Mater. 2014;3:2032–9.

83.Ahmed S, Ikram S. Chitosan based scaffolds and their applications in Wound healing. Achievements in the Life Sciences. 2016;10:27–37.

84.Singh B, Maharjan S, Cho KH, Cui L, Park IK, Choi YJ, et al. Chitosan-based particulate systems for the delivery of mucosal vaccines against infectious diseases. Int J Biol Macromol. 2018;110:54–64.

85.Ma L, Gao C, Mao Z, Zhou J, Shen J, Hu X, et al. Collagen/chitosan porous scaffolds with improved biostability for skin tissue engineering. Biomaterials. 2003;24:4833–41.

86.Islam MM, Shahruzzaman M, Biswas S, Nurus Sakib M, Rashid TU. Chitosan based bioactive materials in tissue engineering applications-a review. Bioact Mater. 2020;5:164–83.

87.Santos TC, Marques AP, Silva SS, Oliveira JM, Mano JF, Castro AG, et al. In vitro evaluation of the behaviour of human polymorphonuclear neutrophils in direct contact with chitosan-based membranes. J Biotechnol. 2007;132:218–26.

88.Rho KS, Jeong L, Lee G, Seo BM, Park YJ, Hong SD, et al. Electrospinning of collagen nanofibers: effects on the behavior of normal human keratinocytes and early-stage wound healing. Biomaterials. 2006;27:1452–61.

89.Chanda A, Adhikari J, Ghosh A, Chowdhury SR, Thomas S, Datta P, et al. Electrospun chitosan/polycaprolactone-hyaluronic acid bilayered scaffold for potential wound healing applications. Int J Biol Macromol. 2018;116:774–85.

90.Sogawa H, Ifuku N, Numata K. 3,4-Dihydroxyphenylalanine (DOPA)-containing silk fibroin: its enzymatic synthesis and adhesion properties. ACS Biomater Sci Eng. 2019;5:5644–51.

91.Kundu B, Rajkhowa R, Kundu SC, Wang X. Silk fibroin biomaterials for tissue regenerations. Adv Drug Deliv Rev. 2013;65:457–70.

92.Roh DH, Kang SY, Kim JY, Kwon YB, Young Kweon H, Lee KG, et al. Wound healing effect of silk fibroin/alginate-blended sponge in full thickness skin defect of rat. J Mater Sci Mater Med. 2006;17:547–52.

93.Yoo CR, Yeo IS, Park KE, Park JH, Lee SJ, Park WH, et al. Effect of chitin/silk fibroin nanofibrous bicomponent structures on interaction with human epidermal keratinocytes. Int J Biol Macromol. 2008;42:324–34.

94.Khorshidi S, Solouk A, Mirzadeh H, Mazinani S, Lagaron JM, Sharifi S, et al. A review of key challenges of electrospun scaffolds for tissue-engineering applications. J Tissue Eng Regen Med. 2016;10:715–38.

95.Saquing CD, Tang C, Monian B, Bonino CA, Manasco JL, Alsberg E, et al. Alginate–polyethylene oxide blend nanofibers and the role of the carrier polymer in electrospinning. Ind Eng Chem Res. 2013;52:8692–704.

96.Akbarinejad A, Ghoorchian A, Kamalabadi M, Alizadeh N. Electrospun soluble conductive polypyrrole nanoparticles for fabrication of highly selective n-butylamine gas sensor. Sens Actuators B Chem. 2016;236:99–108.

97.Joshi M, Adak B, Butola BS. Polyurethane nanocomposite based gas barrier films, membranes and coatings: a review on synthesis, characterization and potential applications. Prog Mater Sci. 2018;97:230–82.

98.Vijayasekaran S, Chirila TV, Hong Y, Tahija SG, Dalton PD, Constable IJ, et al. Poly(1-vinyl-2-pyrrolidinone) hydrogels as vitreous substitutes: histopathological evaluation in the animal eye. J Biomater Sci Polym Ed. 1996;7:685–96.

99.Liu X, Lin T, Fang J, Yao G, Zhao H, Dodson M, et al. In vivo wound healing and antibacterial performances of electrospun nanofibre membranes. J Biomed Mater Res A. 2010;94:499–508.

100.Hiep NT, Lee BT. Electro-spinning of PLGA/PCL blends for tissue engineering and their biocompatibility. J Mater Sci Mater Med. 2010;21:1969–78.

101.Venugopal JR, Zhang Y, Ramakrishna S. In vitro culture of human dermal fibroblasts on electrospun polycaprolactone collagen nanofibrous membrane. Artif Organs. 2006;30:440–6.

102.Cheng Z, Teoh SH. Surface modification of ultra thin poly (epsilon-caprolactone) films using acrylic acid and collagen. Biomaterials. 2004;25:1991–2001.

103.Go EJ, Kang EY, Lee SK, Park S, Kim JH, Park W, et al. An osteoconductive PLGA scaffold with bioactive β-TCP and anti-inflammatory mg(OH)(2) to improve in vivo bone regeneration. Biomater Sci. 2020;8:937–48.

104.El-Rashidy AA, Roether JA, Harhaus L, Kneser U, Boccaccini AR. Regenerating bone with bioactive glass scaffolds: a review of in vivo studies in bone defect models. Acta Biomater. 2017;62:1–28.

105.Homaeigohar S, Li M, Boccaccini AR. Bioactive glass-based fibrous wound dressings. Burns Trauma. 2022;10:tkac038. https://doi.org/10.1093/burnst/tkac038.

106.Kong B, Chen Y, Liu R, Liu X, Liu C, Shao Z, et al. Fiber reinforced GelMA hydrogel to induce the regeneration of corneal stroma. Nat Commun. 2020;11:1435. https://doi.org/10.1038/s41467-020-14887-9.

107.El-Lakany SA, Abd-Elhamid AI, Kamoun EA, El-Fakharany EM, Samy WM, Elgindy NA. α-Bisabolol-loaded cross-linked Zein Nanofibrous 3D-scaffolds for accelerating Wound healing and tissue regeneration in rats. Int J Nanomedicine. 2019;14:8251–70.

108.Sun L, Gao W, Fu X, Shi M, Xie W, Zhang W, et al. Enhanced wound healing in diabetic rats by nanofibrous scaffolds mimicking the basketweave pattern of collagen fibrils in native skin. Biomater Sci. 2018;6:340–9.

109.Jayasinghe SN, Townsend-Nicholson A. Stable electric-field driven cone-jetting of concentrated biosuspensions. Lab Chip. 2006;6:1086–90.

110.Sampson SL, Saraiva L, Gustafsson K, Jayasinghe SN, Robertson BD. Cell electrospinning: an in vitro and in vivo study. Small. 2014;10:78–82.

111.Diegelmann RF, Evans MC. Wound healing: an overview of acute, fibrotic and delayed healing. Front Biosci. 2004;9:283–9.

112.Ellis S, Lin EJ, Tartar D. Immunology of Wound healing. Current Dermatology Reports. 2018;7:350–8.

113.Robson MC, Wound infection. A failure of wound healing caused by an imbalance of bacteria. Surg Clin North Am. 1997;77:637–50.

114.Rajabian MH, Ghorabi GH, Geramizadeh B, Sameni S, Ayatollahi M. Evaluation of bone marrow derived mesenchymal stem cells for full-thickness wound healing in comparison to tissue engineered chitosan scaffold in rabbit. Tissue Cell. 2017;49:112–21.

115.Cui B, Zhang C, Gan B, Liu W, Liang J, Fan Z, et al. Collagen-tussah silk fibroin hybrid scaffolds loaded with bone mesenchymal stem cells promote skin wound repair in rats. Mater Sci Eng C Mater Biol Appl. 2020;109:110611. https://doi.org/10.1016/j.msec.2019.110611.

116.Demidova-Rice TN, Hamblin MR, Herman IM. Acute and impaired wound healing: pathophysiology and current methods for drug delivery, part 2: role of growth factors in normal and pathological wound healing: therapeutic potential and methods of delivery. Adv Skin Wound Care. 2012;25:349–70.

117.Zimolag E, Borowczyk-Michalowska J, Kedracka-Krok S, Skupien-Rabian B, Karnas E, Lasota S, et al. Electric field as a potential directional cue in homing of bone marrow-derived mesenchymal stem cells to cutaneous wounds. Biochim Biophys Acta Mol Cell Res. 2017;1864:267–79.

118.Schlie-Wolter S, Ngezahayo A, Chichkov BN. The selective role of ECM components on cell adhesion, morphology, proliferation and communication in vitro. Exp Cell Res. 2013;319:1553–61.

119.Barker TH. The role of ECM proteins and protein fragments in guiding cell behavior in regenerative medicine. Biomaterials. 2011;32:4211–4.

120.Alenghat FJ, Ingber DE. Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins. Sci STKE. 2002;119:pe6. https://doi.org/10.1126/stke.2002.119.pe6.

121.Berthiaume F, Maguire TJ, Yarmush ML. Tissue engineering and regenerative medicine: history, progress, and challenges. Annu Rev Chem Biomol Eng. 2011;2:403–30.

122.Sengupta S, Parent CA, Bear JE. The principles of directed cell migration. Nat Rev Mol Cell Biol. 2021;22:529–47.

123.Amores De Sousa MC, Rodrigues CAV, IAF F, Diogo MM, Linhardt RJ, Cabral JMS, et al. Functionalization of electrospun nanofibers and Fiber alignment enhance neural stem cell proliferation and neuronal differentiation. Front Bioeng. Biotechnol. 2020;8:580135. https://doi.org/10.3389/fbioe.2020.580135.

124.Chen H, Peng Y, Wu S, Tan LP. Electrospun 3D fibrous scaffolds for chronic Wound repair. Materials (Basel). 2016;9:272. https://doi.org/10.3390/ma9040272.

125.Lowery JL, Datta N, Rutledge GC. Effect of fiber diameter, pore size and seeding method on growth of human dermal fibroblasts in electrospun poly(epsilon-caprolactone) fibrous mats. Biomaterials. 2010;31:491–504.

126.Torres-Sanchez C, Mclaughlin J, Bonallo R. Effect of pore size, morphology and orientation on the bulk stiffness of a porous Ti35Nb4Sn alloy. J Mater Eng Perform. 2018;27:2899–909.

127.Dai T, Kharkwal GB, Tanaka M, Huang YY, Bil De Arce VJ, Hamblin MR. Animal models of external traumatic wound infections. Virulence. 2011;2:296–315.

128.Ding X, Tang Q, Xu Z, Xu Y, Zhang H, Zheng D, et al. Challenges and innovations in treating chronic and acute wound infections: from basic science to clinical practice.. Burns Trauma. 2022;10:tkac014. https://doi.org/10.1093/burnst/tkac014.

129.Pelgrift RY, Friedman AJ. Nanotechnology as a therapeutic tool to combat microbial resistance. Adv Drug Deliv Rev. 2013;65:1803–15.

130.Kamali A, Oryan A, Hosseini S, Ghanian MH, Alizadeh M, Baghaban Eslaminejad M, et al. Cannabidiol-loaded microspheres incorporated into osteoconductive scaffold enhance mesenchymal stem cell recruitment and regeneration of critical-sized bone defects. Mater Sci Eng C Mater Biol Appl. 2019;101:64–75.

131.Wang H, Liu Y, Cai K, Zhang B, Tang S, Zhang W, et al. Antibacterial polysaccharide-based hydrogel dressing containing plant essential oil for burn wound healing. Burns Trauma. 2021;9:tkab041. https://doi.org/10.1093/burnst/tkab041.

132.Ma Y, Jiang K, Chen H, Shi Q, Liu H, Zhong X, et al. Liquid exfoliation of V(8)C(7) nanodots as peroxidase-like nanozymes for photothermal-catalytic synergistic antibacterial treatment. Acta Biomater. 2022;149:359–72.

133.Jin X, Zhang W, Shan J, He J, Qian H, Chen X, et al. Thermosensitive hydrogel loaded with nickel-copper bimetallic hollow Nanospheres with SOD and CAT enzymatic-like activity promotes acute Wound healing. ACS Appl Mater Interfaces. 2022;14:50677–91.

134.Grada A, Mervis J, Falanga V. Research techniques made simple: animal models of Wound healing. J Invest Dermatol. 2018;138:2095–2105.e2091. https://doi.org/10.1016/j.jid.2018.08.005.

135.Mahla RS. Stem cells applications in regenerative medicine and disease therapeutics. Int. J Cell Biol. 2016;2016:6940283. https://doi.org/10.1155/2016/6940283.

136.Wu K, Zhu D, Dai X, Wang W, Zhong X, Fang Z, et al. Bimetallic oxide Cu1.5Mn1.5O4 cage-like frame nanospheres with triple enzyme-like activities for bacterial-infected wound therapy. Nano Today. 2022;43:101380. https://doi.org/10.1016/j.nantod.2022.101380.

137.Yang X, Yang J, Wang L, Ran B, Jia Y, Zhang L, et al. Pharmaceutical intermediate-modified gold nanoparticles: against multidrug-resistant bacteria and Wound-healing application via an electrospun scaffold. ACS Nano. 2017;11:5737–45.

138.Zhang W, Dai X, Jin X, Huang M, Shan J, Chen X, et al. Promotion of wound healing by a thermosensitive and sprayable hydrogel with nanozyme activity and anti-inflammatory properties. Smart Materials in Medicine. 2023;4:134–45.

139.Fang Y, Wang N, Shi L, Barker T, Zhang P. Pain relief during wound care for patients with a deep open wound in an orthopedic trauma department: a best practice implementation project. JBI Database System Rev Implement Rep. 2019;17:2559–69.

140.Chen S, Wang H, Su Y, John JV, Mccarthy A, Wong SL, et al. Mesenchymal stem cell-laden, personalized 3D scaffolds with controlled structure and fiber alignment promote diabetic wound healing. Acta Biomater. 2020;108:153–67.

141.Elahi MF, Lu W. Core-shell Fibers for biomedical applications-a review. J Bioeng Biomed Sci. 2013;3:1–14.

142.Peng Z-X, Wang L, Du L, Guo S-R, Wang X-Q, Tang T-T. Adjustment of the antibacterial activity and biocompatibility of hydroxypropyltrimethyl ammonium chloride chitosan by varying the degree of substitution of quaternary ammonium. Carbohydr Polym. 2010;81:275–83.

143.Orsu P, Haider HY, Koyyada A. Bioengineering for curcumin loaded carboxymethyl guargum/reduced graphene oxide nanocomposites for chronic wound healing applications. Int J Pharm. 2021;606:120928. https://doi.org/10.1016/j.ijpharm.2021.120928.

144.Liang Y, Li M, Yang Y, Qiao L, Xu H, Guo B. pH/glucose dual responsive metformin release hydrogel dressings with adhesion and self-healing via dual-dynamic bonding for athletic diabetic foot Wound healing. ACS Nano. 2022;16:3194–207.

145.Kabilamurthi RS, Abhinav RP, Thiyaneswaran N, Subhashree R, Gajendran PL. Effectiveness of concentrated growth factor on surgical Wound healing: a pilot study. J Long-Term Eff Med Implants. 2021;31:27–32.

146.Huo H, Liu F, Luo Y, Gu Q, Liu Y, Wang Z, et al. Triboelectric nanogenerators for electro-assisted cell printing. Nano Energy. 2020;67:104150. https://doi.org/10.1016/j.nanoen.2019.104150.

147.Zhao S, Agarwal P, Rao W, Huang H, Zhang R, Liu Z, et al. Coaxial electrospray of liquid core-hydrogel shell microcapsules for encapsulation and miniaturized 3D culture of pluripotent stem cells. Integr Biol (Camb). 2014;6:874–84.

148.Chen Y, Abdalkarim SYH, Yu HY, Li Y, Xu J, Marek J, et al. Double stimuli-responsive cellulose nanocrystals reinforced electrospun PHBV composites membrane for intelligent drug release. Int J Biol Macromol. 2020;155:330–9.

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