Targeting neuronal mitophagy in ischemic stroke: an update

Jun Li; Jiaying Wu; Xinyu Zhou; Yangyang Lu; Yuyang Ge; Xiangnan Zhang

doi:10.1093/burnst/tkad018

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Targeting neuronal mitophagy in ischemic stroke: an update

更新时间：2023-08-29

- Targeting neuronal mitophagy in ischemic stroke: an update
- Targeting neuronal mitophagy in ischemic stroke: an update
- Burns & Trauma 2023年11卷第1期
- 作者机构：
  
  1. Department of Clinical Pharmacy
  2. Zhejiang University School of Medicine
  3. Institute of Pharmacology & Toxicology
  4. Zhejiang University
  5. Jinhua Institute of Zhejiang University
- 作者简介：
- 基金信息：
  
  This work was funded by National Natural Science Foundation of China (81973402), Natural Science Foundation of Zhejiang Province (LYY22H310009), Hospital Pharmacy Scientific Research Funding Project of Zhejiang Pharmaceutical Association (2020ZYY10) and Clinical research fund project of Zhejiang Medical Association (2020ZYC–A07).
- DOI：10.1093/burnst/tkad018
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-5-31，
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Jun Li, Jiaying Wu, Xinyu Zhou, 等. Targeting neuronal mitophagy in ischemic stroke: an update[J]. Burns & Trauma, 2023,11(1).

Jun Li, Jiaying Wu, Xinyu Zhou, Yangyang Lu, Yuyang Ge, Xiangnan Zhang, Targeting neuronal mitophagy in ischemic stroke: an update, Burns & Trauma, Volume 11, 2023, tkad018, https://doi.org/10.1093/burnst/tkad018
Jun Li, Jiaying Wu, Xinyu Zhou, 等. Targeting neuronal mitophagy in ischemic stroke: an update[J]. Burns & Trauma, 2023,11(1). DOI： 10.1093/burnst/tkad018.

Jun Li, Jiaying Wu, Xinyu Zhou, Yangyang Lu, Yuyang Ge, Xiangnan Zhang, Targeting neuronal mitophagy in ischemic stroke: an update, Burns & Trauma, Volume 11, 2023, tkad018, https://doi.org/10.1093/burnst/tkad018 DOI：

摘要

Abstract

Cerebral ischemia is a neurological disorder associated with complex pathological mechanisms

including autophagic degradation of neuronal mitochondria

or termed mitophagy

following ischemic events. Despite being well-documented

the cellular and molecular mechanisms underlying the regulation of neuronal mitophagy remain unknown. So far

the evidence suggests neuronal autophagy and mitophagy are separately regulated in ischemic neurons

the latter being more likely activated by reperfusional injury. Specifically

given the polarized morphology of neurons

mitophagy is regulated by different neuronal compartments

with axonal mitochondria being degraded by autophagy in the cell body following ischemia–reperfusion insult. A variety of molecules have been associated with neuronal adaptation to ischemia

including PTEN-induced kinase 1

Parkin

BCL2 and adenovirus E1B 19-kDa-interacting protein 3 (Bnip3)

Bnip3-like (Bnip3l) and FUN14 domain-containing 1. Moreover

it is still controversial whether mitophagy protects against or instead aggravates ischemic brain injury. Here

we review recent studies on this topic and provide an updated overview of the role and regulation of mitophagy during ischemic events.

关键词

Keywords

MitophagyCerebral ischemiaNeuroprotectionPTEN-induced kinase 1ParkinBCL2 and adenovirus E1B 19-kDa-interacting protein 3Bnip3-likeFUN14 domain-containing 1

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