Regulated necrosis pathways: a potential target for ischemic stroke

Kaidi Ren; Jinyan Pei; Yuanyuan Guo; Yuxue Jiao; Han Xing; Yi Xie; Yang Yang; Qi Feng; Jing Yang

doi:10.1093/burnst/tkad016

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Regulated necrosis pathways: a potential target for ischemic stroke

更新时间：2024-02-04

- Regulated necrosis pathways: a potential target for ischemic stroke
- Regulated necrosis pathways: a potential target for ischemic stroke
- Burns & Trauma 2023年11卷第1期
- 作者机构：
  
  1. Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University
  2. Henan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou University
  3. Henan Engineering Research Center for Application & Translation of Precision Clinical Pharmacy
  4. Zhengzhou University
  5. Quality Management Department, Henan No. 3 Provincial People’s Hospital
  6. Department of Neurology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Dong Road, ErQi District, Zhengzhou University
  7. Research Center for Clinical System Biology
  8. The First Affiliated Hospital of Zhengzhou University
  9. Research Institute of Nephrology, The First Affiliated Hospital of Zhengzhou University
  10. Department of Integrated Traditional and Western Nephrology, The First Affiliated Hospital of Zhengzhou University
  11. Henan Province Research Center for Kidney Disease, The First Affiliated Hospital of Zhengzhou University
- 作者简介：
- 基金信息：
  
  This work was supported by the National Key Research and Development Program of China (No. 2020YFC2008304), Natural Science Foundation of Henan Province (No. 222300420350), National Natural Science Foundation of China (No. 82204389), Medical Science and Technique Foundation of Henan Province (No. LHGJ20200310, SBGJ202102145) and Foundation of Henan Educational Committee (No. 21A310027, No. 21A350014), National Natural Science Young Scientists Foundation of China (No. 82200796), China Postdoctoral Science Foundation (No. 2022M722901).
- DOI：10.1093/burnst/tkad016
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-11-18，
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Kaidi Ren, Jinyan Pei, Yuanyuan Guo, 等. Regulated necrosis pathways: a potential target for ischemic stroke[J]. Burns & Trauma, 2023,11(1).

Kaidi Ren, Jinyan Pei, Yuanyuan Guo, Yuxue Jiao, Han Xing, Yi Xie, Yang Yang, Qi Feng, Jing Yang, Regulated necrosis pathways: a potential target for ischemic stroke, Burns & Trauma, Volume 11, 2023, tkad016, https://doi.org/10.1093/burnst/tkad016
Kaidi Ren, Jinyan Pei, Yuanyuan Guo, 等. Regulated necrosis pathways: a potential target for ischemic stroke[J]. Burns & Trauma, 2023,11(1). DOI： 10.1093/burnst/tkad016.

Kaidi Ren, Jinyan Pei, Yuanyuan Guo, Yuxue Jiao, Han Xing, Yi Xie, Yang Yang, Qi Feng, Jing Yang, Regulated necrosis pathways: a potential target for ischemic stroke, Burns & Trauma, Volume 11, 2023, tkad016, https://doi.org/10.1093/burnst/tkad016 DOI：

摘要

Abstract

Globally

ischemic stroke causes millions of deaths per year. The outcomes of ischemic stroke are largely determined by the amount of ischemia-related and reperfusion-related neuronal death in the infarct region. In the infarct region

cell injuries follow either the regulated pathway involving precise signaling cascades

such as apoptosis and autophagy

or the nonregulated pathway

which is uncontrolled by any molecularly defined effector mechanisms such as necrosis. However

numerous studies have recently found that a certain type of necrosis can be regulated and potentially modified by drugs and is nonapoptotic; this type of necrosis is referred to as regulated necrosis. Depending on the signaling pathway

various elements of regulated necrosis contribute to the development of ischemic stroke

such as necroptosis

pyroptosis

ferroptosis

pathanatos

mitochondrial permeability transition pore-mediated necrosis and oncosis. In this review

we aim to summarize the underlying molecular mechanisms of regulated necrosis in ischemic stroke and explore the crosstalk and interplay among the diverse types of regulated necrosis. We believe that targeting these regulated necrosis pathways both pharmacologically and genetically in ischemia-induced neuronal death and protection could be an efficient strategy to increase neuronal survival and regeneration in ischemic stroke.

关键词

Keywords

Ischemic strokeNecroptosisPyroptosisFerroptosisPathanatosmPTP-mediated necrosisOncosis

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Broadening horizons: ferroptosis as a new target for traumatic brain injury