The application of corticosteroids for pathological scar prevention and treatment: current review and update

Meiying Sheng; Yunsheng Chen; Hua Li; Yixin Zhang; Zheng Zhang

doi:10.1093/burnst/tkad009

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The application of corticosteroids for pathological scar prevention and treatment: current review and update

更新时间：2023-05-16

- The application of corticosteroids for pathological scar prevention and treatment: current review and update
- The application of corticosteroids for pathological scar prevention and treatment: current review and update
- Burns & Trauma 2023年11卷第1期
- 作者机构：
  
  1. School of Medicine, Shanghai Jiao Tong University
  2. Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
  3. School of Medicine
- 作者简介：
- 基金信息：
  
  This review was supported by the National Natural Science Foundation of China (grant numbers: 82172222, 82272266 and 82102328), the Shanghai Clinical Research Project of Health Industry (20204Y0443), the Cross Research Project of Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine (JYJC202009) and the Shanghai Clinical Research Center of Plastic and Reconstructive Surgery supported by Science and Technology Commission of Shanghai Municipality (Grant No. 22MC1940300).
- DOI：10.1093/burnst/tkad009
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-3-18，
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Meiying Sheng, Yunsheng Chen, Hua Li, 等. The application of corticosteroids for pathological scar prevention and treatment: current review and update[J]. Burns & Trauma, 2023,11(1).

Meiying Sheng, Yunsheng Chen, Hua Li, Yixin Zhang, Zheng Zhang, The application of corticosteroids for pathological scar prevention and treatment: current review and update, Burns & Trauma, Volume 11, 2023, tkad009, https://doi.org/10.1093/burnst/tkad009
Meiying Sheng, Yunsheng Chen, Hua Li, 等. The application of corticosteroids for pathological scar prevention and treatment: current review and update[J]. Burns & Trauma, 2023,11(1). DOI： 10.1093/burnst/tkad009.

Meiying Sheng, Yunsheng Chen, Hua Li, Yixin Zhang, Zheng Zhang, The application of corticosteroids for pathological scar prevention and treatment: current review and update, Burns & Trauma, Volume 11, 2023, tkad009, https://doi.org/10.1093/burnst/tkad009 DOI：

摘要

Abstract

The prevention and treatment of pathological scars remain challenging. Corticosteroids are the mainstay drugs in clinical scar prevention and treatment as they effectively induce scar regression and improve scar pruritus and pain. Currently

intralesional injections of corticosteroids are widely used in clinical practice. These require professional medical manipulation; however

the significant accompanying injection pain

repetition of injections and adverse effects

such as skin atrophy

skin pigmentation and telangiectasia

make this treatment modality an unpleasant experience for patients. Transdermal administration is

therefore

a promising non-invasive and easy-to-use method for corticosteroid administration for scar treatment. In this review

we first summarize the mechanisms of action of corticosteroids in scar prevention and treatment; then

we discuss current developments in intralesional injections and the progress of transdermal delivery systems of corticosteroids

as well as their corresponding advantages and disadvantages.

关键词

Keywords

CorticosteroidsPathological scarPrevention and treatmentTransdermal drug deliveryAdministration method

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