Targeting macrophage autophagy for inflammation resolution and tissue repair in inflammatory bowel disease

Er-jin Wang; Ming-Yue Wu; Zheng-yu Ren; Ying Zheng; Richard D Ye; Chris Soon Heng TAN; Yitao Wang; Jia-Hong Lu

doi:10.1093/burnst/tkad004

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Targeting macrophage autophagy for inflammation resolution and tissue repair in inflammatory bowel disease

更新时间：2023-08-29

- Targeting macrophage autophagy for inflammation resolution and tissue repair in inflammatory bowel disease
- Targeting macrophage autophagy for inflammation resolution and tissue repair in inflammatory bowel disease
- Burns & Trauma 2023年11卷第1期
- 作者机构：
  
  1. University of Macau
  2. Third Military Medical University (Army Medical University)
  3. The Chinese University of Hong Kong
  4. Southern University of Science and Technology
  5. Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, University of Macau,Guangdong,China
- 作者简介：
- 基金信息：
  
  This study was supported by the Shenzhen Fundamental Research Program (No. SGDX20210823103804030), Science and Technology Development Fund, Macau SAR (No. 0025/2022/A1), the 2020 Guangdong Provincial Science and Technology Innovation Strategy Special Fund (Guangdong-Hong Kong-Macau Joint Lab) (No. 2020B1212030006), Guangdong Basic and Applied Basic Research Foundation (No. 2022A1515012416), National Natural Science Foundation of China (No. 31871024) and the University of Macau grants (No. MYRG2019–00129-ICMS) awarded to JHL.
- DOI：10.1093/burnst/tkad004
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-5-4，
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Er-jin Wang, Ming-Yue Wu, Zheng-yu Ren, 等. Targeting macrophage autophagy for inflammation resolution and tissue repair in inflammatory bowel disease[J]. Burns & Trauma, 2023,11(1).

Er-jin Wang, Ming-Yue Wu, Zheng-yu Ren, Ying Zheng, Richard D Ye, Chris Soon Heng TAN, Yitao Wang, Jia-Hong Lu, Targeting macrophage autophagy for inflammation resolution and tissue repair in inflammatory bowel disease, Burns & Trauma, Volume 11, 2023, tkad004, https://doi.org/10.1093/burnst/tkad004
Er-jin Wang, Ming-Yue Wu, Zheng-yu Ren, 等. Targeting macrophage autophagy for inflammation resolution and tissue repair in inflammatory bowel disease[J]. Burns & Trauma, 2023,11(1). DOI： 10.1093/burnst/tkad004.

Er-jin Wang, Ming-Yue Wu, Zheng-yu Ren, Ying Zheng, Richard D Ye, Chris Soon Heng TAN, Yitao Wang, Jia-Hong Lu, Targeting macrophage autophagy for inflammation resolution and tissue repair in inflammatory bowel disease, Burns & Trauma, Volume 11, 2023, tkad004, https://doi.org/10.1093/burnst/tkad004 DOI：

摘要

Abstract

Inflammatory bowel disease (IBD) is a chronic

non-specific

recurrent inflammatory disease

majorly affecting the gastrointestinal tract. Due to its unclear pathogenesis

the current therapeutic strategy for IBD is focused on symptoms alleviation. Autophagy is a lysosome-mediated catabolic process for maintaining cellular homeostasis. Genome-wide association studies and subsequent functional studies have highlighted the critical role of autophagy in IBD via a number of mechanisms

including modulating macrophage function. Macrophages are the gatekeepers of intestinal immune homeostasis

especially involved in regulating inflammation remission and tissue repair. Interestingly

many autophagic proteins and IBD-related genes have been revealed to regulate macrophage function

suggesting that macrophage autophagy is a potentially important process implicated in IBD regulation. Here

we have summarized current understanding of macrophage autophagy function in pathogen and apoptotic cell clearance

inflammation remission and tissue repair regulation in IBD

and discuss how this knowledge can be used as a strategy for IBD treatment.

关键词

Keywords

AutophagyInflammatory bowel diseasesInflammationTissue repairEfferocytosisMacrophage

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