Myocardial injury: where inflammation and autophagy meet

Chunping Liu; Yanjiao Liu; Huiqi Chen; Xiaofei Yang; Chuanjian Lu; Lei Wang; Jiahong Lu

doi:10.1093/burnst/tkac062

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Myocardial injury: where inflammation and autophagy meet

更新时间：2023-05-16

- Myocardial injury: where inflammation and autophagy meet
- Myocardial injury: where inflammation and autophagy meet
- Burns & Trauma 2023年11卷第1期
- 作者机构：
  
  1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau
  2. State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
  3. Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research,Guangdong
- 作者简介：
- 基金信息：
  
  This work was supported by the National Natural Science Foundation of China (82104495 and 82174161), Shenzhen Fundamental Research Program (No. SGDX20210823103804030), Science and Technology Development Fund, Macau SAR (No. 0025/2022/A1), University of Macau grants (No. MYRG2019-00129-ICMS), Macao Youth Scholars Program (AM2021023), Guangdong Basic and Applied Basic Research Foundation (2022A1515010395 and 2021A1515012573), Science and Technology Foundation of Guangzhou City (202102010257), State Key Laboratory of Dampness Syndrome of Chinese Medicine Research Foundation (SZ2021ZZ21 and SZ2022QN02), Scientific Research Projects of Guangdong Bureau of Traditional Chinese Medicine (Nos. 20212088), TCM Research Fund of Guangdong Provincial Hospital of Chinese Medicine (YN2020MS13) and The 2020 Guangdong Provincial Science and Technology Innovation Strategy Special Fund (Guangdong-Hong Kong-Macau Joint Lab, No. 2020B1212030006 and MY2022KF05).
- DOI：10.1093/burnst/tkac062
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-3-1，
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Chunping Liu, Yanjiao Liu, Huiqi Chen, 等. Myocardial injury: where inflammation and autophagy meet[J]. Burns & Trauma, 2023,11(1).

Chunping Liu, Yanjiao Liu, Huiqi Chen, Xiaofei Yang, Chuanjian Lu, Lei Wang, Jiahong Lu, Myocardial injury: where inflammation and autophagy meet, Burns & Trauma, Volume 11, 2023, tkac062, https://doi.org/10.1093/burnst/tkac062
Chunping Liu, Yanjiao Liu, Huiqi Chen, 等. Myocardial injury: where inflammation and autophagy meet[J]. Burns & Trauma, 2023,11(1). DOI： 10.1093/burnst/tkac062.

Chunping Liu, Yanjiao Liu, Huiqi Chen, Xiaofei Yang, Chuanjian Lu, Lei Wang, Jiahong Lu, Myocardial injury: where inflammation and autophagy meet, Burns & Trauma, Volume 11, 2023, tkac062, https://doi.org/10.1093/burnst/tkac062 DOI：

摘要

Abstract

Autophagy is a highly conserved bulk degradation mechanism that degrades damaged organelles

aged proteins and intracellular contents to maintain the homeostasis of the intracellular microenvironment. Activation of autophagy can be observed during myocardial injury

during which inflammatory responses are strongly triggered. Autophagy can inhibit the inflammatory response and regulate the inflammatory microenvironment by removing invading pathogens and damaged mitochondria. In addition

autophagy may enhance the clearance of apoptotic and necrotic cells to promote the repair of damaged tissue. In this paper

we briefly review the role of autophagy in different cell types in the inflammatory microenvironment of myocardial injury and discuss the molecular mechanism of autophagy in regulating the inflammatory response in a series of myocardial injury conditions

including myocardial ischemia

ischemia/reperfusion injury and sepsis cardiomyopathy.

关键词

Keywords

AutophagyInflammationMyocardial injury

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