Pathological changes in the brain after peripheral burns

Jigang Chen; Danfeng Zhang; Junhui Zhang; Yanni Wang

doi:10.1093/burnst/tkac061

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Pathological changes in the brain after peripheral burns

更新时间：2023-05-16

- Pathological changes in the brain after peripheral burns
- Pathological changes in the brain after peripheral burns
- Burns & Trauma 2023年11卷第1期
- 作者机构：
  
  1. Beijing Children’s Hospital, Capital Medical University, National Center for Children's Health
  2. Shanghai Changzheng Hospital, Second Military Medical University
  3. Southwest Hospital, Third Military Medical University
  4. Department of Geriatric Oncology, Department of Palliative care
- 作者简介：
- 基金信息：
  
  Natural Science Foundation of China (82101433).
- DOI：10.1093/burnst/tkac061
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-2-6，
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Jigang Chen, Danfeng Zhang, Junhui Zhang, 等. Pathological changes in the brain after peripheral burns[J]. Burns & Trauma, 2023,11(1).

Jigang Chen, Danfeng Zhang, Junhui Zhang, Yanni Wang, Pathological changes in the brain after peripheral burns, Burns & Trauma, Volume 11, 2023, tkac061, https://doi.org/10.1093/burnst/tkac061
Jigang Chen, Danfeng Zhang, Junhui Zhang, 等. Pathological changes in the brain after peripheral burns[J]. Burns & Trauma, 2023,11(1). DOI： 10.1093/burnst/tkac061.

Jigang Chen, Danfeng Zhang, Junhui Zhang, Yanni Wang, Pathological changes in the brain after peripheral burns, Burns & Trauma, Volume 11, 2023, tkac061, https://doi.org/10.1093/burnst/tkac061 DOI：

摘要

Abstract

Brain injuries are common complications in patients with thermal burns and are associated with unpleasant outcomes. In clinical settings

it was once believed that brain injuries were not major pathological processes after burn

at least in part due to the unavailability of specific clinical manifestations. Burn-related brain injuries have been studied for more than a century

but the underlying pathophysiology has not been completely clarified. This article reviews the pathological changes in the brain following peripheral burns at the anatomical

histological

cytological

molecular and cognitive levels. Therapeutic indications based on brain injury as well as future directions for research have been summarized and proposed.

关键词

Keywords

BurnBrain injuriesPathological changesBlood–brain barrierInflammation

references

1.Jaworska M, Hanc I. Cerebral tissue reaction to burn trauma in children. Acta Chir Plast. 1965;7:52–7.

2.Kruse F. Enzephalitis und amaurose nach verbrennung. Dtsch Med Wochenschr. 1928;54:1039–41.

3.Antoon AY, Volpe JJ, Crawford JD. Burn encephalopathy in children. Pediatrics. 1972;50:609–16.

4.Mohnot D, Snead OC, III, Benton JW, Jr. Burn encephalopathy in children. Ann Neurol. 1982;12:42–7.

5.Daroff RB, Aminoff MJ. Encyclopedia of the neurological sciences.Cambridge, Massachusetts: Academic Press, 2014.

6.Emery JL, Campbell Reid DA. Cerebral edema and spastic hemiplegia following minor burns in young children. Br J Surg. 1962;50:53–6.

7.Erb I, Morgan EM, Farmer A. The pathology of burns: the pathologic picture as revealed at autopsy in a series of 61 fatal cases treated at the hospital for sick children, Toronto, Canada. Ann Surg. 1943;117:234–55.

8.Madow L, Alpers B. Brain changes in patients with extensive body burns. AMA Archives of Neurology Psychiatry. 1954;72:440–51.

9.Roth N. Encephalopathy due to burns: report of a case. Arch Neurol Psychiatr. 1941;45:980–3.

10.Crawford T. Burns: pathology and therapeutic applications. J Clin Pathol. 1958;11:287.

11.Warlow CP, Hinton P. Early neurological disturbances following relatively minor burns in children. Lancet. 1969;294:978–82.

12.Li Y, Chen Y. Pathomorphological changes of the brain in 58 autopsies of severe body surface burn patients (in Chinese). Journal of Third Military Medical University. 1993;15:317–20.

13.Itkin SI. Histopathological changes in the central nervous system in experimental burns. Exsp Khir Anesteziol. 1971;16:56–9.

14.Winkelman MD, Galloway PG. Central nervous system complications of thermal burns. A postmortem study of 139 patients. Medicine. 1992;71:271–83.

15.Cogswell J, Chu A. Severe burns in children, 1964-1974. Arch Dis Child. 1976;51:67–72.

16.Williams FN, Herndon DN, Hawkins HK, Lee JO, Cox RA, Kulp GA, et al. The leading causes of death after burn injury in a single pediatric burn center. Crit Care. 2009;13:R183–7.

17.Flierl MA, Stahel PF, Touban BM, Beauchamp KM, Morgan SJ, Smith WR, et al. Bench-to-bedside review: burn-induced cerebral inflammation–a neglected entity? Crit Care. 2009;13:215–8.

18.Gregorios JB. Leukoencephalopathy associated with extensive burns. J Neurol Neurosurg Psychiatry. 1982;45:898–904.

19.Rosenberg M, Robertson C, Murphy KD, Rosenberg L, Mlcak R, Robert RS, et al. Neuropsychological outcomes of pediatric burn patients who sustained hypoxic episodes. Burns. 2005;31:883–9.

20.Shin C, Kinsky MP, Thomas JA, Traber DL, Kramer GC. Effect of cutaneous burn injury and resuscitation on the cerebral circulation in an ovine model. Burns. 1998;24:39–45.

21.Randolph AC, Fukuda S, Ihara K, Enkhbaatar P, Micci M-A. Blood–brain barrier dysfunction after smoke inhalation injury, with and without skin burn. Shock. 2019;51:634–49.

22.Caprini JA, Lipp V, Zuckerman L, Vagher JP, Winchester DP. Hematologic changes following burns. J Surg Res. 1977;22:626–35.

23.Simon TL, Curreri PW, Harker LA. Kinetic characterization of hemostasis in thermal injury. The Journal of laboratory clinical medicine. 1977;89:702–11.

24.Calvano TP, Hospenthal DR, Renz EM, Wolf SE, Murray CK. Central nervous system infections in patients with severe burns. Burns. 2010;36:688–91.

25.Vaughn L, Beckel N. Severe burn injury, burn shock, and smoke inhalation injury in small animals. Part 1: burn classification and pathophysiology. Journal of veterinary emergency. Crit Care. 2012;22:179–86.

26.Pereira CT, Murphy KD, Herndon DN. Altering metabolism. J Burn Care Rehabil. 2005;26:194–9.

27.Ganrot K, Jacobsson S, Rothman U. Transcapillary passage of plasma proteins in experimental burns. Acta Physiol Scand. 1974;91:497–501.

28.Keck M, Herndon DH, Kamolz LP, Frey M, Jeschke MG. Pathophysiology of burns. Wien Med Wochenschr. 2009;159:327–36.

29.Latenser BA. Critical care of the burn patient: the first 48 hours. Crit Care Med. 2009;37:2819–26.

30.Carleton S, Tomassoni AJ, Alexander JK. Cardiac problems associated with burns. Cardiol Clin. 1995;13:257–78.

31.Duffy BJ, McLaughlin PM, Eichelberger MR. Assessment, triage, and early management of burns in children. Clinical Pediatric Emergency Medicine. 2006;7:82–93.

32.Jeschke MG, Mlcak RP, Finnerty CC, Norbury WB, Gauglitz GG, Kulp GA, et al. Burn size determines the inflammatory and hypermetabolic response. Crit Care. 2007;11:R90–11.

33.Hatef DA, Hollier LH, Jr. Pathophysiologic response to severe burn injury. J Craniofac Surg. 2009;20:1300–1.

34.Panerai RB. Cerebral autoregulation: from models to clinical applications. Cardiovasc Eng. 2008;8:42–59.

35.Sun J, Li H, Ying D, Bian X, He B. Effects of dynamic changes of intracranial pressure on the brain edema in the early stage of severely burned dogs (in Chinese). Journal of Third Military Medical University. 2004;26:1105–7.

36.Chi Y, Liu X, Chai J. A narrative review of changes in microvascular permeability after burn. Annals of Translational Medicine. 2021;9:719.

37.Moati F, Miskulin M, Godeau G, Robert A. Blood-brain barrier permeabilizing activity in sera of severe-burn patients. Neurochem Res. 1979;4:377–83.

38.Barone C, Jimenez D, Huxley V, Yang X. Cerebral vascular response to hypertonic fluid resuscitation in thermal injury. In: Brain Edema X.Vienna, Austria: Springer, 1997, 265–6.

39.Barone CM, Jimenez DF, Huxley VH, Yang X. In vivo visualization of cerebral microcirculation in systemic thermal injury. The Journal of burn care rehabilitation. 2000;21:20–5.

40.Hu J, Zhang Y, Ding S, Li H. Dynamic observation on opening of the blood–brain barrier in the primary stage of severely scalded rabbits, a multimodal study. J Burn Care Res. 2016;37:e279–86.

41.Barone C, Jimenez F, Huxley V, Yang X-F. Morphologic analysis of the cerebral microcirculation after thermal injury and the response to fluid resuscitation. In: Brain Edema X.Vienna, Austria: Springer, 1997, 267–8.

42.Li H, Ying D, Sun J, Bian X, Li Q. A canine model of brain edema established in the early postburn stage (in Chinese). Chinese Journal of Burns. 2000;16:153–6.

43.Li H, Ying D, He X, Sun J, Chen L. Stereoscopic study on capillary density of early brain oedema in a dog postburn model. Injury. 2009;40:835–9.

44.Li H, Ying D, He X, Sun J. Stereographic study on cerebral capillary density of dogs with cerebral edema at early stage of severe burn (in Chinese). Journal of Third Military Medical University. 2001;23:179–81.

45.Cannon JG, Friedberg JS, Gelfand JA, Tompkins RG, Burke JF, Dinarello CA. Circulating interleukin-1 beta and tumor necrosis factor-alpha concentrations after burn injury in humans. Crit Care Med. 1992;20:1414–9.

46.De Bandt JP, Chollet-Martin S, Hernvann A, Lioret N, Du Roure LD, Lim S-K, et al. Cytokine response to burn injury: relationship with protein metabolism. J Trauma. 1994;36:624–8.

47.Reyes R, Jr, Wu Y, Lai Q, Mrizek M, Berger J, Jimenez DF, et al. Early inflammatory response in rat brain after peripheral thermal injury. Neurosci Lett. 2006;407:11–5.

48.Mulder PP, Vlig M, Boekema BK, Stoop MM, Pijpe A, Van Zuijlen PP, et al. Persistent systemic inflammation in patients with severe burn injury is accompanied by influx of immature neutrophils and shifts in T cell subsets and cytokine profiles. Front Immunol. 2021;11:621222.

49.Terao S, Yilmaz G, Stokes KY, Russell J, Ishikawa M, Kawase T, et al. Blood cell-derived RANTES mediates cerebral microvascular dysfunction, inflammation, and tissue injury after focal ischemia–reperfusion. Stroke. 2008;39:2560–70.

50.McColl BW, Rothwell NJ, Allan SM. Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice. J Neurosci. 2008;28:9451–62.

51.Swann K, Berger J, Sprague SM, Wu Y, Lai Q, Jimenez DF, et al. Peripheral thermal injury causes blood–brain barrier dysfunction and matrix metalloproteinase (MMP) expression in rat. Brain Res. 2007;1129:26–33.

52.Berger J, Sprague SM, Wu Y, Davis WW, Jimenez DF, Barone CM, et al. Peripheral thermal injury causes early blood–brain barrier dysfunction and matrix metalloproteinase expression in rat. Neurol Res. 2007;29:610–4.

53.Patel TH, Sprague S, Lai Q, Jimenez DF, Barone CM, Ding Y. Blood brain barrier (BBB) dysfunction associated with increased expression of tissue and urokinase plasminogen activators following peripheral thermal injury. Neurosci Lett. 2008;444:222–6.

54.Reyes R, Guo M, Swann K, Shetgeri SU, Sprague SM, Jimenez DF, et al. Role of tumor necrosis factor–α and matrix metalloproteinase–9 in blood-brain barrier disruption after peripheral thermal injury in rats. J Neurosurg. 2009;110:1218–26.

55.Rempe RG, Hartz AM, Bauer B. Matrix metalloproteinases in the brain and blood–brain barrier: versatile breakers and makers. J Cereb Blood Flow Metab. 2016;36:1481–507.

56.Vandebroek A, Yasui M. Regulation of AQP4 in the central nervous system. Int J Mol Sci. 2020;21:1603.

57.Luo S, Sun S, Wang K. Change of aquaporion-4 expression and its significance in cerebral edema after severe burn (in Chinese). Chinese Journal of Trauma. 2007;23:465–8.

58.Niogi SN, Mukherjee P. Diffusion tensor imaging of mild traumatic brain injury. J Head Trauma Rehabil. 2010;25:241–55.

59.Tidwell AS, Robertson ID. Magnetic resonance imaging of normal and abnormal brain perfusion. Vet Radiol Ultrasound. 2011;52:S62–71.

60.Glover GH. Overview of functional magnetic resonance imaging. Neurosurgery Clinics. 2011;22:133–9.

61.Hare RD, Smith AM, Forster BB, MacKay AL, Whittall KP, Kiehl KA, et al. Functional magnetic resonance imaging: the basics of blood-oxygen-level dependent (BOLD) imaging. Can Assoc Radiol J. 1998;49:320.

62.Jiang S, Tan Y, Zheng S, Lei W, Wang F, Hong F, et al. Study on mechanism of rabbits brain injury in early stage of severe burn based on magnetic resonance imaging Bold-fMRI, DWI and DTI imaging technology (in Chinese). Journal of Clinical and Experimental Medicine. 2018;17:2061–4.

63.Huang Y, Jiang S, Tan Y. Comparison of magnetic resonance Bold-fMRI and DWI in the diagnosis of burn with cerebral damage (in Chinese). Journal of Brain And Nervous Diseases. 2020;28:243–6.

64.Xing J, Chu X, Ding L, Qiao H, Liu J. The abnormalities of the default mode network of resting-state fMRI on the patients with extremely severe burn trauma: an study by independent component analysis (in Chinese). Journal of Chinese Clinical Medical Imaging. 2020;31:851–4.

65.Zhang Q, Chen Q, Kang J, Liu C, Dong N, Zhu X, et al. Treatment with gelsolin reduces brain inflammation and apoptotic signaling in mice following thermal injury. J Neuroinflammation. 2011;8:1–18.

66.Saglam IY, Ozdamar EN, Demiralay E, Sehirli AO, Sener G, Saglam E. The effect of captopril on brain apoptosis after burn injury in rats. Turk Neurosurg. 2013;23:366–71.

67.Wu S-H, Huang S-H, Cheng K-I, Chai C-Y, Yeh J-L, Wu T-C, et al. Third-degree hindpaw burn injury induced apoptosis of lumbar spinal cord ventral horn motor neurons and sciatic nerve and muscle atrophy in rats. Biomed Res Int. 2015;2015:1–9.

68.Ma L, Zhou Y, Khan MA, Yasuhara S, Martyn JJ. Burn-induced microglia activation is associated with motor neuron degeneration and muscle wasting in mice. Shock. 2019;51:569.

69.Thameem Dheen S, Kaur C, Ling E-A. Microglial activation and its implications in the brain diseases. Curr Med Chem. 2007;14:1189–97.

70.Li G, Wu W, Hoa J, Dong N, Yao Y, Zhang Q. Infiltration of immune cells and neuron apoptosis in brain after moderate burn injury: experiment with mice (in Chinese). Chinese Journal of Emergency Resuscitation and Disaster Medicine. 2018;13:50–4.

71.Gatson JW, Maass DL, Simpkins JW, Idris AH, Minei JP, Wigginton JG. Estrogen treatment following severe burn injury reduces brain inflammation and apoptotic signaling. J Neuroinflammation. 2009;6:1–10.

72.Rothlein R. Overview of leukocyte adhesion. Neurology. 1997;49:S3–4.

73.Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 1994;76:301–14.

74.Ahmed SE-DS, El-Shahat AS, Saad SO. Assessment of certain neutrophil receptors, opsonophagocytosis and soluble intercellular adhesion molecule-1 (ICAM-1) following thermal injury. Burns. 1999;25:395–401.

75.Nwariaku FE, Mileski WJ, Lightfoot E, Sikes PJ, Lipsky PE. Alterations in leukocyte adhesion molecule expression after burn injury. J Trauma Acute Care Surg. 1995;39:285–8.

76.Zhang Q, Li J, Dong N, Tang L, Zhu X, Sheng Z, et al. Burn injury induces gelsolin expression and cleavage in the brain of mice. Neurosci Lett. 2013;228:60–72.

77.Parihar A, Parihar MS, Milner S, Bhat S. Oxidative stress and anti-oxidative mobilization in burn injury. Burns. 2008;34:6–17.

78.Faunce DE, Llanas JN, Patel PJ, Gregory MS, Duffner LA, Kovacs EJ. Neutrophil chemokine production in the skin following scald injury. Burns. 1999;25:403–10.

79.Gauglitz GG, Song J, Herndon DN, Finnerty CC, Boehning D, Barral JM, et al. Characterization of the inflammatory response during acute and post-acute phases after severe burn. Shock. 2008;30:503.

80.Meager A. Cytokine regulation of cellular adhesion molecule expression in inflammation. Cytokine Growth Factor Rev. 1999;10:27–39.

81.Argaw AT, Zhang Y, Snyder BJ, Zhao M, Kopp N, Lee SC, et al. IL-1β regulates blood-brain barrier permeability via reactivation of the hypoxia-angiogenesis program. J Immunol. 2006;177:5574–84.

82.Paul R, Koedel U, Winkler F, Kieseier BC, Fontana A, Kopf M, et al. Lack of IL-6 augments inflammatory response but decreases vascular permeability in bacterial meningitis. Brain. 2003;126:1873–82.

83.Tecchio C, Micheletti A, Cassatella MA. Neutrophil-derived cytokines: facts beyond expression. Front Immunol. 2014;5:508.

84.Singhal G, Jaehne EJ, Corrigan F, Toben C, Baune BT. Inflammasomes in neuroinflammation and changes in brain function: a focused review. Front Neurosci. 2014;8:315.

85.Rawlingson A. Nitric oxide, inflammation and acute burn injury. Burns. 2003;29:631–40.

86.Förstermann U. Endothelial NO synthase as a source of NO and superoxide. Eur J Clin Pharmacol. 2006;62:5–12.

87.Becker WK, Shippee RL, McManus AT, Mason AD, Jr, Pruitt BA, Jr. Kinetics of nitrogen oxide production following experimental thermal injury in rats. J Trauma. 1993;34:855–62.

88.Carter E, Derojas-Walker T, Tamir S, Tannenbaum S, Yu Y-M, Tompkins R. Nitric oxide production is intensely and persistently increased in tissue by thermal injury. Biochem J. 1994;304:201–4.

89.Lestaevel P, Agay D, Peinnequin A, Cruz C, Cespuglio R, Clarençon D, et al. Effects of a thermal injury on brain and blood nitric oxide (NO) content in the rat. Burns. 2003;29:557–62.

90.Halm M-P, Poquin D, Lestaevel P, Chancerelle Y, Graff C. Brain and cognitive impairments from burn injury in rats. Burns. 2006;32:570–6.

91.Sehba FA, Schwartz AY, Chereshnev I, Bederson JB. Acute decrease in cerebral nitric oxide levels after subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2000;20:604–11.

92.Sehba FA, Hou J, Pluta RM, Zhang JH. The importance of early brain injury after subarachnoid hemorrhage. Prog Neurobiol. 2012;97:14–37.

93.Gutteridge JM, Halliwell B. Iron toxicity and oxygen radicals. Baillieres Clin Haematol. 1989;2:195–256.

94.Sies H. Strategies of antioxidant defense. Eur J Biochem. 1993;215:213–9.

95.Robinson JM. Phagocytic leukocytes and reactive oxygen species. Histochem Cell Biol. 2009;131:465–9.

96.Till G, Hatherill J, Tourtellotte W, Lutz M, Ward P. Lipid peroxidation and acute lung injury after thermal trauma to skin. Evidence of a role for hydroxyl radical. Am J Pathol. 1985;119:376.

97.Haycock JW, Ralston DR, Morris B, Freedlander E, MacNeil S. Oxidative damage to protein and alterations to antioxidant levels in human cutaneous thermal injury. Burns. 1997;23:533–40.

98.Hoşnuter M, Gürel A, Babucçu O, Armutcu F, Kargi E, Işikdemir A. The effect of CAPE on lipid peroxidation and nitric oxide levels in the plasma of rats following thermal injury. Burns. 2004;30:121–5.

99.Gürbüz V, Corak A, Yeğen B, Kurtel H, Alican I. Oxidative organ damage in a rat model of thermal injury: the effect of cyclosporin a. Burns. 1997;23:37–42.

100.Cobley JN, Fiorello ML, Bailey DM. 13 reasons why the brain is susceptible to oxidative stress. Redox Biol. 2018;15:490–503.

101.Cai Q, Liu Y, Zhang B, Zhang X, Zheng R. Early changes of injured brain tissues and superoxide dismutase and malondialdehyde in severely burned rats after delayed fluid resuscitation at high altitude (in Chinese). Chinese Journal Experimental Surgery. 2008;25:1579–81.

102.Mårtensson J, Goodwin CW, Blake R. Mitochondrial glutathione in hypermetabolic rats following burn injury and thyroid hormone administration: evidence of a selective effect on brain glutathione by burn injury. Metabolism. 1992;41:273–7.

103.Ogita H, Liao JK. Endothelial function and oxidative stress. Endothelium. 2004;11:123–32.

104.Song K, Li Y, Zhang H, An N, Wei Y, Wang L, et al. Oxidative stress-mediated blood-brain barrier (BBB) disruption in neurological diseases. Oxidative Med Cell Longev. 2020;2020:1–27.

105.Liang J, Wu S, Xie W, He H. Ketamine ameliorates oxidative stress-induced apoptosis in experimental traumatic brain injury via the Nrf2 pathway. Drug Design, Development Therapy. 2018;Volume 12:845–53.

106.Hart D, Wolf S, Mlcak R, Chinkes D, Ramzy P, Obeng M, et al. Persistence of muscle catabolism after severe burn. Surgery. 2000;128:312–9.

107.Reiss E, Pearson E, Artz CP, Balikov B. The metabolic response to burns. J Clin Invest. 1956;35:62–77.

108.Wilmore DW, Mason AD, Jr, Pruitt BA, Jr. Insulin response to glucose in hypermetabolic burn patients. Ann Surg. 1976;183:314.

109.Yu Y, Tompkins RG, Ryan CM, Young VR. The metabolic basis of the increase in energy expenditure in severely burned patients. J Parenter Enter Nutr. 1999;23:160–8.

110.Williams FN, Herndon DN, Jeschke MG. The hypermetabolic response to burn injury and interventions to modify this response. Clin Plast Surg. 2009;36:583–96.

111.Chance WT, Nelson JL, Kim M, Foley-Nelson T, Chen M, Fischer JE. Burn-induced alterations in feeding, energy expenditure, and brain amine neurotransmitters in rats. J Trauma. 1987;27:503–9.

112.Chance WT, Nelson JL, Foley-Nelson T, Kim MW, Fischer JE. The relationship of burn-induced hypermetabolism to central and peripheral catecholamines. J Trauma. 1989;29:306–12.

113.Chance WT, Berlatzky Y, Minnema K, Trocki O, Alexander JW, Fischer JE. Burn trauma induces anorexia and aberrations in CNS amine neurotransmitters. J Trauma. 1985;25:501–7.

114.Hart DW, Wolf SE, Chinkes DL, Lal SO, Ramzy PI, Herndon DN. β-Blockade and growth hormone after burn. Ann Surg. 2002;236:450.

115.Herndon DN, Hart DW, Wolf SE, Chinkes DL, Wolfe RR. Reversal of catabolism by beta-blockade after severe burns. N Engl J Med. 2001;345:1223–9.

116.Wilmore DW, Orcutt TW, Mason AD, Jr, Pruitt BA. Alterations in hypothalamic function following thermal injury. J Trauma. 1975;15:697–703.

117.Palmieri TL, Levine S, Schonfeld-Warden N, O'Mara MS, Greenhalgh DG. Hypothalamic–pituitary–adrenal axis response to sustained stress after major burn injury in children. J Burn Care Res. 2006;27:742–8.

118.Fuchs PC, Groger A, Bozkurt A, Johnen D, Wolter T, Pallua N. Cortisol in severely burned patients: investigations on disturbance of the hypothalamic-pituitary-adrenal axis. Shock. 2007;28:662–7.

119.Fauerbach JA, McKibben J, Bienvenu OJ, Magyar-Russell G, Smith MT, Holavanahalli R, et al. Psychological distress after major burn injury. Psychosom Med. 2007;69:473–82.

120.Fauerbach JA, Lezotte D, Hills RA, Cromes GF, Kowalske K, De Lateur BJ, et al. The 2004 clinical research award: burden of burn: a norm-based inquiry into the influence of burn size and distress on recovery of physical and psychosocial function. J Burn Care Rehabil. 2005;26:21–32.

121.Madianos MG, Papaghelis M, Ioannovich J, Dafni R. Psychiatric disorders in burn patients: a follow-up study. Psychother Psychosom. 2001;70:30–7.

122.Difede J, Ptacek J, Roberts J, Barocas D, Rives W, Apfeldorf W, et al. Acute stress disorder after burn injury: a predictor of posttraumatic stress disorder? Psychosom Med. 2002;64:826–34.

123.Van Loey N, Maas C, Faber A, Taal L. Predictors of chronic posttraumatic stress symptoms following burn injury: results of a longitudinal study. Journal of Traumatic Stress: Official Publication of The International Society for Traumatic Stress Studies. 2003;16:361–9.

124.Fukunishi I. Relationship of cosmetic disfigurement to the severity of posttraumatic stress disorder in burn injury or digital amputation. Psychother Psychosom. 1999;68:82–6.

125.Ali H, Pervaiz M. Depression in adults post burn injury: a descriptive study conducted in the burn Centre of a tertiary care hospital in Karachi. Ann Burns Fire Disasters. 2019;32:33.

126.Thombs BD, Bresnick MG, Magyar-Russell G. Depression in survivors of burn injury: a systematic review. Gen Hosp Psychiatry. 2006;28:494–502.

127.Wiechman S, Ptacek J, Patterson D, Gibran N, Engrav L, Heimbach D. Rates, trends, and severity of depression after burn injuries. J Burn Care Rehabil. 2001;22:417–24.

128.Boeve S, Aaron L, Martin-Herz S, Peterson A, Cain V, Heimbach DM, et al. Sleep disturbance after burn injury. J Burn Care Rehabil. 2002;23:32–8.

129.Low JA, Dyster-Aas J, Willebrand M, Kildal M, Gerdin B, Ekselius L. Chronic nightmares after severe burns: risk factors and implications for treatment. J Burn Care Rehabil. 2003;24:260–7.

130.Raymond I, Nielsen TA, Lavigne G, Manzini C, Choinière M. Quality of sleep and its daily relationship to pain intensity in hospitalized adult burn patients. Pain. 2001;92:381–8.

131.Van Loey NE, Van Son MJ. Psychopathology and psychological problems in patients with burn scars. Am J Clin Dermatol. 2003;4:245–72.

132.Bakker A, Maertens KJ, Van Son MJ, Van Loey NE. Psychological consequences of pediatric burns from a child and family perspective: a review of the empirical literature. Clin Psychol Rev. 2013;33:361–71.

133.Martin-Herz SP, Thurber CA, Patterson DR. Psychological principles of burn wound pain in children. II: treatment applications. J Burn Care Rehabil. 2000;21:458–72.

134.Woolard A, Hill N, McQueen M, Martin L, Milroy H, Wood FM, et al. The psychological impact of paediatric burn injuries: a systematic review. BMC Public Health. 2021;21:1–27.

135.Watson EJ, Nenadlová K, Clancy OH, Farag M, Nordin NA, Nilsen A, et al. Perioperative research into memory (PRiMe): cognitive impairment following a severe burn injury and critical care admission, part 1. Burns. 2018;44:1167–78.

136.Purohit M, Goldstein R, Nadler D, Mathews K, Slocum C, Gerrard P, et al. Cognition in patients with burn injury in the inpatient rehabilitation population. Arch Phys Med Rehabil. 2014;95:1342–9.

137.Kohman RA, Rhodes JS. Neurogenesis, inflammation and behavior. Brain Behav Immun. 2013;27:22–32.

138.Gorelick PB. Role of inflammation in cognitive impairment: results of observational epidemiological studies and clinical trials. Ann N Y Acad Sci. 2010;1207:155–62.

139.Liu H, Zhang F, Lineaweaver WC. History and advancement of burn treatments. Ann Plast Surg. 2017;78:S2–8.

140.Lee KC, Joory K, Moiemen NS. History of burns: the past, present and the future. Burns & trauma. 2014;2:169–3868.143620.

141.Guilabert P, Usúa G, Martín N, Abarca L, Barret J, Colomina M. Fluid resuscitation management in patients with burns: update. BJA: British Journal of Anaesthesia. 2016;117:284–96.

142.Chang K-C, Ma H, Liao W-C, Lee C-K, Lin C-Y, Chen C-c. The optimal time for early burn wound excision to reduce pro-inflammatory cytokine production in a murine burn injury model. Burns. 2010;36:1059–66.

143.Ng SY, Lee AYW. Traumatic brain injuries: pathophysiology and potential therapeutic targets. Front Cell Neurosci. 2019;13:528.

144.Xi G, Keep RF, Hoff JT. Mechanisms of brain injury after intracerebral haemorrhage. The Lancet Neurology. 2006;5: 53–63.

145.Thapa K, Khan H, Singh TG, Kaur A. Traumatic brain injury: mechanistic insight on pathophysiology and potential therapeutic targets. J Mol Neurosci. 2021;71:1725–42.

146.Belur PK, Chang JJ, He S, Emanuel BA, Mack WJ. Emerging experimental therapies for intracerebral hemorrhage: targeting mechanisms of secondary brain injury. Neurosurg Focus. 2013;34:E9.

147.Chen G, Shi J, Hang C, Xie W, Liu J, Liu X. Inhibitory effect on cerebral inflammatory agents that accompany traumatic brain injury in a rat model: a potential neuroprotective mechanism of recombinant human erythropoietin (rhEPO). Neurosci Lett. 2007;425:177–82.

148.Nichol A, French C, Little L, Haddad S, Presneill J, Arabi Y, et al. Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial. Lancet. 2015;386:2499–506.

149.Kabadi SV, Faden AI. Neuroprotective strategies for traumatic brain injury: improving clinical translation. Int J Mol Sci. 2014;15:1216–36.

150.Xu S, Pan S. The failure of animal models of neuroprotection in acute ischemic stroke to translate to clinical efficacy. Med Sci Monit Basic Res. 2013;19:37–45.

151.Liu X, Wu W, Li Q, Huang X, Chen B, Du J, et al. Effect of sphingosine 1-phosphate on morphological and functional responses in endothelia and venules after scalding injury. Burns. 2009;35:1171–9.

152.Ji Q, Jia H, Dai H, Li W, Zhang L. Protective effects of pentoxifylline on the brain following remote burn injury. Burns. 2010;36:1300–8.

153.Demiralay E, Saglam IY, Ozdamar EN, Sehirli AO, Sener G, Saglam E. nNOS expression in the brain of rats after burn and the effect of the ACE inhibitor captopril. Burns. 2013;39:897–904.

154.Loane DJ, Kumar A. Microglia in the TBI brain: the good, the bad, and the dysregulated. Exp Neurol. 2016;275:316–27.

155.Dasari R, Bonsack F, Sukumari-Ramesh S. Brain injury and repair after intracerebral hemorrhage: the role of microglia and brain-infiltrating macrophages. Neurochem Int. 2021;142:104923.

156.Heinz R, Brandenburg S, Nieminen-Kelhä M, Kremenetskaia I, Boehm-Sturm P, Vajkoczy P, et al. Microglia as target for anti-inflammatory approaches to prevent secondary brain injury after subarachnoid hemorrhage (SAH). J Neuroinflammation. 2021;18:1–13.

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