Autophagy in acute kidney injury and maladaptive kidney repair

Yu Xiang; Ying Fu; Wenwen Wu; Chengyuan Tang; Zheng Dong

doi:10.1093/burnst/tkac059

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Autophagy in acute kidney injury and maladaptive kidney repair

更新时间：2023-05-16

- Autophagy in acute kidney injury and maladaptive kidney repair
- Autophagy in acute kidney injury and maladaptive kidney repair
- Burns & Trauma 2023年11卷第1期
- 作者机构：
  
  1. Department of Nephrology
  2. The Second Xiangya Hospital at Central South University
  3. Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood VA Medical Center
- 作者简介：
- 基金信息：
  
  The work was supported partly by grants from the National Natural Science Foundation of China (81720108008, 82090024), the National Key R&D Program of China (2020YFC2005000).
- DOI：10.1093/burnst/tkac059
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-1-22，
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Yu Xiang, Ying Fu, Wenwen Wu, 等. Autophagy in acute kidney injury and maladaptive kidney repair[J]. Burns & Trauma, 2023,11(1).

Yu Xiang, Ying Fu, Wenwen Wu, Chengyuan Tang, Zheng Dong, Autophagy in acute kidney injury and maladaptive kidney repair, Burns & Trauma, Volume 11, 2023, tkac059, https://doi.org/10.1093/burnst/tkac059
Yu Xiang, Ying Fu, Wenwen Wu, 等. Autophagy in acute kidney injury and maladaptive kidney repair[J]. Burns & Trauma, 2023,11(1). DOI： 10.1093/burnst/tkac059.

Yu Xiang, Ying Fu, Wenwen Wu, Chengyuan Tang, Zheng Dong, Autophagy in acute kidney injury and maladaptive kidney repair, Burns & Trauma, Volume 11, 2023, tkac059, https://doi.org/10.1093/burnst/tkac059 DOI：

摘要

Abstract

Acute kidney injury (AKI) is a major renal disease characterized by a sudden decrease in kidney function. After AKI

the kidney has the ability to repair

but if the initial injury is severe the repair may be incomplete or maladaptive and result in chronic kidney problems. Autophagy is a highly conserved pathway to deliver intracellular contents to lysosomes for degradation. Autophagy plays an important role in maintaining renal function and is involved in the pathogenesis of renal diseases. Autophagy is activated in various forms of AKI and acts as a defense mechanism against kidney cell injury and death. After AKI

autophagy is maintained at a relatively high level in kidney tubule cells during maladaptive kidney repair but the role of autophagy in maladaptive kidney repair has been controversial. Nonetheless

recent studies have demonstrated that autophagy may contribute to maladaptive kidney repair after AKI by inducing tubular degeneration and promoting a profibrotic phenotype in renal tubule cells. In this review

we analyze the role and regulation of autophagy in kidney injury and repair and discuss the therapeutic strategies by targeting autophagy.

关键词

Keywords

AutophagyAcute kidney injuryMaladaptive repairFibrosisChronic kidney disease

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