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Role of inflammation in neurological damage and regeneration following spinal cord injury and its therapeutic implications
Role of inflammation in neurological damage and regeneration following spinal cord injury and its therapeutic implications
- Burns & Trauma 2023年11卷第1期
- 作者机构：
1. Key Laboratory of Neuroregeneration of Jiangsu and the Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products，Nantong University
2. School of Life Sciences, Nantong University
3. School of Medicine, Nantong University
4. NICM Health Research Institute, Western Sydney University
5. Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-sen University), Ministry of Education
6. innovation Center of Neuroregeneration, Nantong University,Co
- 作者简介：
- 基金信息：This work was supported by the National Key R&D Program of China (2022YFA1105900), the National Natural Science Foundation of China (81701127), the Nantong Science and Technology Foundation of China (JC2021058) and the Large Instruments Open Foundation of Nantong University (KFJN2231, KFJN2275). TL is supported by the National Health and Medical Research Council (NHMRC) Early Career Fellowship (Grant No. 1112258) and WSU Vice-Chancellor’s Senior Research Fellowship.
DOI：10.1093/burnst/tkac054
中图分类号：纸质出版日期：2023，
网络出版日期：2023-2-28，
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Yan Jin, Yixing Song, Jiaqi Lin, 等. Role of inflammation in neurological damage and regeneration following spinal cord injury and its therapeutic implications[J]. Burns & Trauma, 2023,11(1).
Yan Jin, Yixing Song, Jiaqi Lin, Tianqing Liu, Guicai Li, Biqin Lai, Yun Gu, Gang Chen, Lingyan Xing, Role of inflammation in neurological damage and regeneration following spinal cord injury and its therapeutic implications, Burns & Trauma, Volume 11, 2023, tkac054, https://doi.org/10.1093/burnst/tkac054
Yan Jin, Yixing Song, Jiaqi Lin, 等. Role of inflammation in neurological damage and regeneration following spinal cord injury and its therapeutic implications[J]. Burns & Trauma, 2023,11(1). DOI： 10.1093/burnst/tkac054.
Yan Jin, Yixing Song, Jiaqi Lin, Tianqing Liu, Guicai Li, Biqin Lai, Yun Gu, Gang Chen, Lingyan Xing, Role of inflammation in neurological damage and regeneration following spinal cord injury and its therapeutic implications, Burns & Trauma, Volume 11, 2023, tkac054, https://doi.org/10.1093/burnst/tkac054 DOI：
摘要
Abstract
Spinal cord injury (SCI) is an incurable trauma that frequently results in partial or complete loss of motor and sensory function. Massive neurons are damaged after the initial mechanical insult. Secondary injuries
which are triggered by immunological and inflammatory responses
also result in neuronal loss and axon retraction. This results in defects in the neural circuit and a deficiency in the processing of information. Although inflammatory responses are necessary for spinal cord recovery
conflicting evidence of their contributions to specific biological processes have made it difficult to define the specific role of inflammation in SCI. This review summarizes our understanding of the complex role of inflammation in neural circuit events following SCI
such as cell death
axon regeneration and neural remodeling. We also review the drugs that regulate immune responses and inflammation in the treatment of SCI and discuss the roles of these drugs in the modulation of neural circuits. Finally
we provide evidence about the critical role of inflammation in facilitating spinal cord neural circuit regeneration in zebrafish
an animal model with robust regenerative capacity
to provide insights into the regeneration of the mammalian central nervous system.
关键词
Keywords
InflammationImmune responseSpinal cord injuryAxon regenerationCell deathZebrafishInflammatory drugsTraumaNeurological damage
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