Zn2+-Loaded adhesive bacterial cellulose hydrogel with angiogenic and antibacterial abilities for accelerating wound healing

Zhengzhe Han; Lili Deng; Shiyan Chen; Huaping Wang; Yinjun Huang

doi:10.1093/burnst/tkac048

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Zn2+-Loaded adhesive bacterial cellulose hydrogel with angiogenic and antibacterial abilities for accelerating wound healing

更新时间：2023-05-16

- Zn2+-Loaded adhesive bacterial cellulose hydrogel with angiogenic and antibacterial abilities for accelerating wound healing
- Zn2+-Loaded adhesive bacterial cellulose hydrogel with angiogenic and antibacterial abilities for accelerating wound healing
- Burns & Trauma 2023年11卷第1期
- 作者机构：
  
  1. and Shanghai Institute of Microsurgery on Extremities, Shanghai Sixth People's Hospital
  2. Donghua University
  3. Shanghai Jiao Tong University School of Medicine
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkac048
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-2-3，
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Zhengzhe Han, Lili Deng, Shiyan Chen, 等. Zn2+-Loaded adhesive bacterial cellulose hydrogel with angiogenic and antibacterial abilities for accelerating wound healing[J]. Burns & Trauma, 2023,11(1).

Zhengzhe Han, Lili Deng, Shiyan Chen, Huaping Wang, Yinjun Huang, Zn2+-Loaded adhesive bacterial cellulose hydrogel with angiogenic and antibacterial abilities for accelerating wound healing, Burns & Trauma, Volume 11, 2023, tkac048, https://doi.org/10.1093/burnst/tkac048
Zhengzhe Han, Lili Deng, Shiyan Chen, 等. Zn2+-Loaded adhesive bacterial cellulose hydrogel with angiogenic and antibacterial abilities for accelerating wound healing[J]. Burns & Trauma, 2023,11(1). DOI： 10.1093/burnst/tkac048.

Zhengzhe Han, Lili Deng, Shiyan Chen, Huaping Wang, Yinjun Huang, Zn2+-Loaded adhesive bacterial cellulose hydrogel with angiogenic and antibacterial abilities for accelerating wound healing, Burns & Trauma, Volume 11, 2023, tkac048, https://doi.org/10.1093/burnst/tkac048 DOI：

摘要

Abstract

BackgroundWound healing is a process that requires angiogenesis and antibacterial activities and it remains a challenge for both experimental and clinical research worldwide. Zn2+ has been reported to be widely involved in angiogenesis and exerts antibacterial effects

making it suitable as a treatment to promote wound healing. Therefore Zn2+-loaded adhesive bacterial cellulose hydrogel was designed to observe its angiogenic and antibacterial abilities in the wound healing process.MethodsThe characterization

tensile strength

swelling behaviors and antibacterial activity of bacterial cellulose/polydopamine/zeolitic imidazolate framework-8 (BC/PDA/ZIF8) hydrogels were tested. Cell-Counting-Kit-8 (CCK8)

transwell

tube formation and real time qunantitative PCR (qRT-PCR) assays were performed to evaluate the cell compatibility of BC/PDA/ZIF8 hydrogels in vitro. A full-thickness defect wound model and histological assays were used to evaluate the BC/PDA/ZIF8 hydrogels in vivo.ResultsThe prepared BC/PDA/ZIF8 hydrogels exhibited suitable mechanical strength

excellent swelling properties

good tissue adhesion

efficient angiogenic and antibacterial effects and good performance as a physical barrier. In vivo experiments showed that the BC/PDA/ZIF8 hydrogels accelerated wound healing in a full-thickness defect wound model by stimulating angiogenesis.ConclusionsThis study proved that BC/PDA/ZIF8 hydrogels possess great potential for promoting satisfactory wound healing in full-thickness wound defects through antibacterial effects and improved cell proliferation

tissue formation

remodeling and re-epithelialization.

关键词

Keywords

HydrogelMechanical propertiesBiocompatibilityAngiogenic effectsWound healing

references

1.Armstrong DG, Boulton AJM, Bus SA. Diabetic Foot Ulcers and Their Recurrence. New England Journal of Medicine New England Journal of Medicine (NEJM/MMS). 2017;376:2367–75. Available from: https://www.nejm.org/doi/10.1056/NEJMra1615439.

2.Saleh B, Kaur Dhaliwal H, Portillo-Lara R, Shirzaei Sani E, Abdi R, Amiji MM, et al. Local Immunomodulation Using an Adhesive Hydrogel Loaded with miRNA-Laden Nanoparticles Promotes Wound Healing. Small [Internet] John Wiley & Sons, Ltd. 2019 [cited 2022 Jan 24];15:1902232. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/smll.201902232.

3.Jones RE, Foster DS, Longaker MT. Management of Chronic Wounds - 2018. JAMA - Journal of the American Medical Association American Medical Association. 2018;320:1481–2. Available from: https://doi.org/10.1001/jama.2018.12426.

4.Zeng R, Lin C, Lin Z, Chen H, Lu W, Lin C, et al. Approaches to cutaneous wound healing: basics and future directions. Cell Tissue Res Springer Verlag. 2018;374:217–32. Available from: https://doi.org/10.1007/s00441-018-2830-1.

5.Rosenbaum AJ, Banerjee S, Rezak KM, Uhl RL. Advances in wound management. Journal of the American Academy of Orthopaedic Surgeons Lippincott Williams and Wilkins. 2018;26:833–43. Available from: https://doi.org/10.5435/JAAOS-D-17-00024.

6.Chen Q, Zhu L, Chen H, Yan H, Huang L, Yang J, et al. A novel design strategy for fully physically linked double network hydrogels with tough, fatigue resistant, and self- Healing properties. Adv Funct Mater Wiley-VCH Verlag. 2015;25:1598–607. Available from: https://doi.org/10.1002/adfm.201404357.

7.Feng Z, Zuo H, Gao W, Ning N, Tian M, Zhang Feng LZ, et al. A Robust, Self-Healable, and Shape Memory Supramolecular Hydrogel by Multiple Hydrogen Bonding Interactions. Macromol Rapid Commun [Internet] John Wiley & Sons, Ltd. 2018 [cited 2022 Jan 24];39:1800138. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/marc.201800138.

8.Zheng L, Li S, Luo J, Wang X. Latest Advances on Bacterial Cellulose-Based Antibacterial Materials as Wound Dressings. Front Bioeng Biotechnol Frontiers Media SA. 2020;8. Available from: https://doi.org/10.3389/fbioe.2020.593768.

9.Luo Z, Liu J, Lin H, Ren X, Tian H, Liang Y, et al. In situ fabrication of nano zno/bcm biocomposite based on ma modified bacterial cellulose membrane for antibacterial and wound healing. Int J Nanomedicine Dove Medical Press Ltd. 2020;15:1–15. Available from: https://doi.org/10.2147/IJN.S231556.

10.Daria Ciecholewska-Juśko, Anna Żywicka, Adam Junka, Radosław Drozd, Peter Sobolewski, Paweł Migdał, et al. Superabsorbent crosslinked bacterial cellulose biomaterials for chronic wound dressings. Carbohydrate Polymers (IF 10.723). 2020. https://doi.org/10.1016/j.carbpol.2020.117247.

11.Wang YJ, Li CY, Wang ZJ, Zhao Y, Chen L, Wu ZL, et al. Hydrogen bond-reinforced double-network hydrogels with ultrahigh elastic modulus and shape memory property. J Polym Sci B Polym Phys John Wiley and Sons Inc. 2018;56:1281–6. Available from: https://doi.org/10.1002/polb.24620.

12.Yang J, Cristian V, Dong A, Zhang J. A Facile Strategy to Achieve Synergistic Multiple Hydrogen Bonding Interactions for Constructing Robust Hydrogels with Self-healing Capability, Shape Transformation and Actuation Function. Macromol Chem Phys John Wiley and Sons Inc. 2021;222. Available from: https://doi.org/10.1002/macp.202000429.

13.Ciecholewska-Juśko D, Żywicka A, Junka A, Drozd R, Sobolewski P, Migdał P, et al. Superabsorbent crosslinked bacterial cellulose biomaterials for chronic wound dressings. Carbohydr Polym Elsevier Ltd. 2021;253. Available from: https://doi.org/10.1016/j.carbpol.2020.117247.

14.Wu Z, Chen S, Wu R, Sheng N, Zhang M, Ji P, et al. Top-down peeling bacterial cellulose to high strength ultrathin films and multifunctional fibers. Chemical Engineering Journal Elsevier BV. 2020;391. Available from: https://doi.org/10.1016/j.cej.2019.123527.

15.Peng Y, He D, Ge X, Lu Y, Chai Y, Zhang Y, et al. Construction of heparin-based hydrogel incorporated with Cu5.4O ultrasmall nanozymes for wound healing and inflammation inhibition. Bioact Mater Elsevier. 2021;6:3109–24. Available from: https://doi.org/10.1016/j.bioactmat.2021.02.006.

16.Liao M, Wan P, Wen J, Gong M, Wu X, Wang Y, et al. Wearable, Healable, and Adhesive Epidermal Sensors Assembled from Mussel-Inspired Conductive Hybrid Hydrogel Framework. Adv Funct Mater Wiley-VCH Verlag. 2017;27. Available from: https://doi.org/10.1002/adfm.201703852.

17.Rong Q, Lei W, Chen L, Yin Y, Zhou J, Liu M. Anti-freezing, Conductive Self-healing Organohydrogels with Stable Strain-Sensitivity at Subzero Temperatures. Angewandte Chemie - International Edition Wiley-VCH Verlag. 2017;56:14159–63. Available from: https://doi.org/10.1002/anie.201708614.

18.Li A, Han Z, Li Z, Li J, Li X, Zhang Z. A PTHrP-2 loaded adhesive cellulose acetate nanofiber mat as wound dressing accelerates wound healing. Mater Des Elsevier. 2021;212:110241. Available from: https://doi.org/10.1016/j.matdes.2021.110241.

19.Ardekani NT, Khorram M, Zomorodian K, Yazdanpanah S, Veisi H, Veisi H. Evaluation of electrospun poly (vinyl alcohol)-based nanofiber mats incorporated with Zataria multiflora essential oil as potential wound dressing. Int J Biol Macromol Elsevier BV. 2019;125:743–50. Available from: https://doi.org/10.1016/j.ijbiomac.2018.12.085.

20.Adeli H, Khorasani MT, Parvazinia M. Wound dressing based on electrospun PVA/chitosan/starch nanofibrous mats: Fabrication, antibacterial and cytocompatibility evaluation and in vitro healing assay. Int J Biol Macromol Elsevier BV. 2019;122:238–54. Available from: https://doi.org/10.1016/j.ijbiomac.2018.10.115.

21.Ullah A, Ullah S, Khan MQ, Hashmi M, Nam PD, Kato Y, et al. Manuka honey incorporated cellulose acetate nanofibrous mats: Fabrication and in vitro evaluation as a potential wound dressing. Int J Biol Macromol Elsevier. 2020;155:479–89. Available from: https://doi.org/10.1016/j.ijbiomac.2020.03.237.

22.Banno K, Yoder MC. Tissue regeneration using endothelial colony-forming cells: promising cells for vascular repair. Pediatr Res Nature Publishing Group. 2018;83:283–90. Available from: https://doi.org/10.1038/pr.2017.231.

23.McDonald AI, Shirali AS, Aragón R, Ma F, Hernandez G, Vaughn DA, et al. Endothelial regeneration of large vessels is a biphasic process driven by local cells with distinct proliferative capacities. Cell Stem Cell Cell Press. 2018;23:210, e216. Available from:–25. https://doi.org/10.1016/j.stem.2018.07.011.

24.Liu H, Li Z, Zhao Y, Feng Y, Zvyagin AV, Wang J, et al. Novel Diabetic Foot Wound Dressing Based on Multifunctional Hydrogels with Extensive Temperature-Tolerant, Durable, Adhesive, and Intrinsic Antibacterial Properties. ACS Appl Mater Interfaces American Chemical Society. 2021;13:26770–81. Available from: https://doi.org/10.1021/acsami.1c05514.

25.Huang J, Lin D, Wei Z, Li Q, Zheng J, Zheng Q, et al. Parathyroid Hormone Derivative with Reduced Osteoclastic Activity Promoted Bone Regeneration via Synergistic Bone Remodeling and Angiogenesis. Small Wiley-VCH Verlag. 2020;16. Available from: https://doi.org/10.1002/smll.201905876.

26.Mi B, Chen L, Xiong Y, Yang Y, Panayi AC, Xue H, et al. Osteoblast/Osteoclast and Immune Cocktail Therapy of an Exosome/Drug Delivery Multifunctional Hydrogel Accelerates Fracture Repair. ACS Nano [Internet] American Chemical Society. 2022 [cited 2022 Apr 1];16:771–82. Available from: https://pubs.acs.org/doi/full/10.1021/acsnano.1c08284.

27.Götz W, Reichert C, Canullo L, Jäger A, Heinemann F. Coupling of osteogenesis and angiogenesis in bone substitute healing - A brief overview. Ann Anat. 2012;194:171–3. Available from: https://doi.org/10.1016/j.aanat.2011.10.002.

28.Karimi A, Khataee A, Vatanpour V, Safarpour M. High-flux PVDF mixed matrix membranes embedded with size-controlled ZIF-8 nanoparticles. Sep Purif Technol Elsevier BV. 2019;229. Available from: https://doi.org/10.1016/j.seppur.2019.115838.

29.Mao L, Wang L, Zhang M, Ullah MW, Liu L, Zhao W, et al. In Situ Synthesized Selenium Nanoparticles-Decorated Bacterial Cellulose/Gelatin Hydrogel with Enhanced Antibacterial, Antioxidant, and Anti-Inflammatory Capabilities for Facilitating Skin Wound Healing. Adv Healthc Mater John Wiley and Sons Inc. 2021;10. Available from: https://doi.org/10.1002/adhm.202100402.

30.Zhai R, Chen X, Jin M, Hu J. Synthesis of a polydopamaine nanoparticle/bacterial cellulose composite for use as a biocompatible matrix for laccase immobilization. Cellulose Springer Netherlands. 2019;26:8337–49. Available from: https://doi.org/10.1007/s10570-019-02588-6.

31.Zhang M, Shang Q, Wan Y, Cheng Q, Liao G, Pan Z. Self-template synthesis of double-shell TiO2@ZIF-8 hollow nanospheres via sonocrystallization with enhanced photocatalytic activities in hydrogen generation. Appl Catal B Elsevier BV. 2019;241:149–58. Available from: https://doi.org/10.1016/j.apcatb.2018.09.036.

32.Fan Z, Liu B, Wang J, Zhang S, Lin Q, Gong P, et al. A novel wound dressing based on Ag/graphene polymer hydrogel: Effectively kill bacteria and accelerate wound healing. Adv Funct Mater Wiley-VCH Verlag. 2014;24:3933–43. Available from: https://doi.org/10.1002/adfm.201304202.

33.Li Y, Tian Y, Zheng W, Feng Y, Huang R, Shao J, et al. Composites of Bacterial Cellulose and Small Molecule-Decorated Gold Nanoparticles for Treating Gram-Negative Bacteria-Infected Wounds. Small [Internet] John Wiley & Sons, Ltd. 2017 [cited 2022 Apr 26];13:1700130. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/smll.201700130.

34.Lai C, Zhang SJ, Sheng LY, Xi TF. Comparative evaluation of the biocompatible and physical-chemical properties of poly(lactide-co-glycolide) and polydopamine as coating materials for bacterial cellulose. J Mater Chem B Royal Society of Chemistry. 2019;7:630–9. Available from: https://doi.org/10.1039/C8TB02456A.

35.Wang B, Lv X, Li Z, Zhang M, Yao J, Sheng N, et al. Urethra-inspired biomimetic scaffold: A therapeutic strategy to promote angiogenesis for urethral regeneration in a rabbit model. Acta Biomater Acta Materialia Inc. 2020;102:247–58. Available from: https://doi.org/10.1016/j.actbio.2019.11.026.

36.Yang L, Chen C, Hu Y, Wei F, Cui J, Zhao Y, et al. Three-dimensional bacterial cellulose/polydopamine/TiO2 nanocomposite membrane with enhanced adsorption and photocatalytic degradation for dyes under ultraviolet-visible irradiation. J Colloid Interface Sci Academic Press. 2020;562:21–8. Available from: https://doi.org/10.1016/j.jcis.2019.12.013.

37.Inoue Y, Hasegawa S, Ban S, Yamada T, Date Y, Mizutani H, et al. ZIP2 protein, a zinc transporter, is associated with keratinocyte differentiation. Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology Inc. 2014;289:21451–62. Available from: https://doi.org/10.1074/jbc.M114.560821.

38.Xiao J, Zhou Y, Ye M, An Y, Wang K, Wu Q, et al. Freeze-Thawing Chitosan/Ions Hydrogel Coated Gauzes Releasing Multiple Metal Ions on Demand for Improved Infected Wound Healing. Adv Healthc Mater John Wiley and Sons Inc. 2021;10. Available from: https://doi.org/10.1002/adhm.202001591.

39.Wang Y, Ying T, Li J, Xu Y, Wang R, Ke Q, et al. Hierarchical micro/nanofibrous scaffolds incorporated with curcumin and zinc ion eutectic metal organic frameworks for enhanced diabetic wound healing via anti-oxidant and anti-inflammatory activities. Chemical Engineering Journal Elsevier BV. 2020;402. Available from: https://doi.org/10.1016/j.cej.2020.126273.

40.Zhang M, Chen S, Zhong L, Wang B, Wang H, Hong F. Zn2+−loaded TOBC nanofiber-reinforced biomimetic calcium alginate hydrogel for antibacterial wound dressing[J]. Int J Biol Macromol. 2020;143:235–42. Available from: https://doi.org/10.1016/j.ijbiomac.2019.12.046.

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