Skin biomechanics: a potential therapeutic intervention target to reduce scarring

Motaharesadat Hosseini; Jason Brown; Kiarash Khosrotehrani; Ardeshir Bayat; Abbas Shafiee

doi:10.1093/burnst/tkac036

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Skin biomechanics: a potential therapeutic intervention target to reduce scarring

更新时间：2023-09-05

- Skin biomechanics: a potential therapeutic intervention target to reduce scarring
- Skin biomechanics: a potential therapeutic intervention target to reduce scarring
- Burns & Trauma 2022年10卷第1期
- 作者机构：
  
  1. Centre for Biomedical Technologies
  2. Queensland University of Technology
  3. Herston Biofabrication Institute, Metro North Hospital and Health Service
  4. Royal Brisbane and Women's Hospital, Metro North Hospital and Health Service
  5. The University of Queensland Diamantina Institute, Translational Research Institute, The University of Queensland
  6. Centre for Dermatology Research
  7. University of Manchester
  8. MRC-SA Wound Healing Unit
  9. University of Cape Town
- 作者简介：
- 基金信息：
  
  The authors acknowledge the financial support from Metro North Hospital and Health Service, Brisbane, Australia.
- DOI：10.1093/burnst/tkac036
  中图分类号：
- 纸质出版日期：2022，
  
  网络出版日期：2022-8-23，
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Skin biomechanics: a potential therapeutic intervention target to reduce scarring[J]. Burns & Trauma, 2022,10(1).

Motaharesadat Hosseini, Jason Brown, Kiarash Khosrotehrani, Ardeshir Bayat, Abbas Shafiee, Skin biomechanics: a potential therapeutic intervention target to reduce scarring, Burns & Trauma, Volume 10, 2022, tkac036, https://doi.org/10.1093/burnst/tkac036
Skin biomechanics: a potential therapeutic intervention target to reduce scarring[J]. Burns & Trauma, 2022,10(1). DOI： 10.1093/burnst/tkac036.

Motaharesadat Hosseini, Jason Brown, Kiarash Khosrotehrani, Ardeshir Bayat, Abbas Shafiee, Skin biomechanics: a potential therapeutic intervention target to reduce scarring, Burns & Trauma, Volume 10, 2022, tkac036, https://doi.org/10.1093/burnst/tkac036 DOI：

摘要

Abstract

Pathological scarring imposes a major clinical and social burden worldwide. Human cutaneous wounds are responsive to mechanical forces and convert mechanical cues to biochemical signals that eventually promote scarring. To understand the mechanotransduction pathways in cutaneous scarring and develop new mechanotherapy approaches to achieve optimal scarring

the current study highlights the mechanical behavior of unwounded and scarred skin as well as intra- and extracellular mechanisms behind keloid and hypertrophic scars. Additionally

the therapeutic interventions that promote optimal scar healing by mechanical means at the molecular

cellular or tissue level are extensively reviewed. The current literature highlights the significant role of fibroblasts in wound contraction and scar formation via differentiation into myofibroblasts. Thus

understanding myofibroblasts and their responses to mechanical loading allows the development of new scar therapeutics. A review of the current clinical and preclinical studies suggests that existing treatment strategies only reduce scarring on a small scale after wound closure and result in poor functional and aesthetic outcomes. Therefore

the perspective of mechanotherapies needs to consider the application of both mechanical forces and biochemical cues to achieve optimal scarring. Moreover

early intervention is critical in wound management; thus

mechanoregulation should be conducted during the healing process to avoid scar maturation. Future studies should either consider combining mechanical loading (pressure) therapies with tension offloading approaches for scar management or developing more effective early therapies based on contraction-blocking biomaterials for the prevention of pathological scarring.

关键词

Keywords

Dermal fibrosisMechanotransductionPressure therapyTension therapyWound healingSkin biomechanics

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