Strategies for improving adipose-derived stem cells for tissue regeneration

Xin Yuan; Li Li; Haofan Liu; Jing Luo; Yongchao Zhao; Cheng Pan; Xue Zhang; Yuwen Chen; Maling Gou

doi:10.1093/burnst/tkac028

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Strategies for improving adipose-derived stem cells for tissue regeneration

更新时间：2023-09-05

- Strategies for improving adipose-derived stem cells for tissue regeneration
- Strategies for improving adipose-derived stem cells for tissue regeneration
- Burns & Trauma 2022年10卷第1期
- 作者机构：
  
  1. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University
  2. Department of Plastic and Burn Surgery, West China Hospital, Sichuan University
- 作者简介：
- 基金信息：
  
  This work was supported by National Key Research and Development Program of China (2021YFF1200800, MLG), Sichuan Innovative Research Team Program for Young Scientists (2021JDTD0001, MLG), Post-Doctor Research Project, West China Hospital, Sichuan University (2020HXBH025, XY), 1·3·5 project for disciplines of excellence, West China Hospital, Sichuan University (ZYJC18017, MLG;ZYJC21079, CP).
- DOI：10.1093/burnst/tkac028
  中图分类号：
- 纸质出版日期：2022，
  
  网络出版日期：2022-8-16，
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Strategies for improving adipose-derived stem cells for tissue regeneration[J]. Burns & Trauma, 2022,10(1).

Xin Yuan, Li Li, Haofan Liu, Jing Luo, Yongchao Zhao, Cheng Pan, Xue Zhang, Yuwen Chen, Maling Gou, Strategies for improving adipose-derived stem cells for tissue regeneration, Burns & Trauma, Volume 10, 2022, tkac028, https://doi.org/10.1093/burnst/tkac028
Strategies for improving adipose-derived stem cells for tissue regeneration[J]. Burns & Trauma, 2022,10(1). DOI： 10.1093/burnst/tkac028.

Xin Yuan, Li Li, Haofan Liu, Jing Luo, Yongchao Zhao, Cheng Pan, Xue Zhang, Yuwen Chen, Maling Gou, Strategies for improving adipose-derived stem cells for tissue regeneration, Burns & Trauma, Volume 10, 2022, tkac028, https://doi.org/10.1093/burnst/tkac028 DOI：

摘要

Abstract

Adipose-derived stem cells (ADSCs) have promising applications in tissue regeneration. Currently

there are only a few ADSC products that have been approved for clinical use. The clinical application of ADSCs still faces many challenges. Here

we review emerging strategies to improve the therapeutic efficacy of ADSCs in tissue regeneration. First

a great quantity of cells is often needed for the stem cell therapies

which requires the advanced cell expansion technologies. In addition cell-derived products are also required for the development of ‘cell-free’ therapies to overcome the drawbacks of cell-based therapies. Second

it is necessary to strengthen the regenerative functions of ADSCs

including viability

differentiation and paracrine ability

for the tissue repair and regeneration required for different physiological and pathophysiological conditions. Third

poor delivery efficiency also restricts the therapeutic effect of ADSCs. Effective methods to improve cell delivery include alleviating harsh microenvironments

enhancing targeting ability and prolonging cell retention. Moreover

we also point out some critical issues about the sources

effectiveness and safety of ADSCs. With these advanced strategies to improve the therapeutic efficacy of ADSCs

ADSC-based treatment holds great promise for clinical applications in tissue regeneration.

关键词

Keywords

Adipose-derived stem cellsTissue regenerationStem cell therapy

references

1.Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, et al. Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies. Tissue Eng. 2001;7:211–28.

2.Coleman SR. Structural Fat Grafting: More Than a Permanent Filler. Plast Reconstr Surg. 2006;118:108S–20.

3.Granel B, Daumas A, Jouve E, Harlé J-R, Nguyen P-S, Chabannon C, et al. Safety, tolerability and potential efficacy of injection of autologous adipose-derived stromal vascular fraction in the fingers of patients with systemic sclerosis: an open-label phase I trial. Ann Rheum Dis. 2015;74:2175–82.

4.Magalon J, Velier M, Simoncini S, François P, Bertrand B, Daumas A, et al. Molecular profile and proangiogenic activity of the adipose-derived stromal vascular fraction used as an autologous innovative medicinal product in patients with systemic sclerosis. Ann Rheum Dis. 2019;78:391–8.

5.Panés J, García-Olmo D, Van Assche G, Colombel JF, Reinisch W, Baumgart DC, et al. Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn’s disease: a phase 3 randomised, double-blind controlled trial. Lancet. 2016;388:1281–90.

6.Kølle S-FT, Fischer-Nielsen A, Mathiasen AB, Elberg JJ, Oliveri RS, Glovinski PV, et al. Enrichment of autologous fat grafts with ex-vivo expanded adipose tissue-derived stem cells for graft survival: a randomised placebo-controlled trial. Lancet. 2013;382:1113–20.

7.Bourin P, Bunnell BA, Casteilla L, Dominici M, Katz AJ, March KL, et al. Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT). Cytotherapy. 2013;15:641–8.

8.Baglioni S, Francalanci M, Squecco R, Lombardi A, Cantini G, Angeli R, et al. Characterization of human adult stem-cell populations isolated from visceral and subcutaneous adipose tissue. FASEB J. 2009;23:3494–505.

9.Zhang D, Ni N, Wang Y, Tang Z, Gao H, Ju Y, et al. CircRNA-vgll3 promotes osteogenic differentiation of adipose-derived mesenchymal stem cells via modulating miRNA-dependent integrin α5 expression. Cell Death Differ. 2021;28:283–302.

10.Estes BT, Diekman BO, Gimble JM, Guilak F. Isolation of adipose-derived stem cells and their induction to a chondrogenic phenotype. Nat Protoc. 2010;5:1294–311.

11.Rosen ED, Spiegelman BM. Molecular Regulation of Adipogenesis. Annu Rev Cell Dev Biol. 2000;16:145–71.

12.Aurich H, Sgodda M, Kaltwaßer P, Vetter M, Weise A, Liehr T, et al. Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo. Gut. 2009;58:570–81.

13.Banas A, Teratani T, Yamamoto Y, Tokuhara M, Takeshita F, Quinn G, et al. Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes. Hepatology. 2007;46:219–28.

14.Arderiu G, Peña E, Aledo R, Juan-Babot O, Crespo J, Vilahur G, et al. MicroRNA-145 Regulates the Differentiation of Adipose Stem Cells Toward Microvascular Endothelial Cells and Promotes Angiogenesis. Circ Res. 2019;125:74–89.

15.Valérie P-B, Jean-Sébastien S, Béatrice C, Mireille A, Maryse N, Radia T, et al. Plasticity of Human Adipose Lineage Cells Toward Endothelial Cells. Circulation. 2004;109:656–63.

16.Jeon Eun S, Sun PW, Jeong LM, Mi KY, Jin H, Ho KJ. A Rho Kinase/Myocardin-Related Transcription Factor-A–Dependent Mechanism Underlies the Sphingosylphosphorylcholine-Induced Differentiation of Mesenchymal Stem Cells Into Contractile Smooth Muscle Cells. Circ Res. 2008;103:635–42.

17.Rodríguez LV, Alfonso Z, Zhang R, Leung J, Wu B, Ignarro LJ. Clonogenic multipotent stem cells in human adipose tissue differentiate into functional smooth muscle cells. PNAS. 2006;103:12167–72.

18.Bansal V, De D, An J, Kang TM, Jeong H-J, Kang J-S, et al. Chemical induced conversion of mouse fibroblasts and human adipose-derived stem cells into skeletal muscle-like cells. Biomaterials. 2019;193:30–46.

19.Nagata H, Ii M, Kohbayashi E, Hoshiga M, Hanafusa T, Asahi M. Cardiac Adipose-Derived Stem Cells Exhibit High Differentiation Potential to Cardiovascular Cells in C57BL/6 Mice: Therapeutic Cardiac Adipose-Derived Stem Cells. Stem Cells Transl Med. 2016;5:141–51.

20.Wystrychowski W, Patlolla B, Zhuge Y, Neofytou E, Robbins RC, Beygui RE. Multipotency and cardiomyogenic potential of human adipose-derived stem cells from epicardium, pericardium, and omentum. Stem Cell Res Ther. 2016;7:84.

21.Huang C-W, Lu S-Y, Huang T-C, Huang B-M, Sun HS, Yang S-H, et al. FGF9 induces functional differentiation to Schwann cells from human adipose derived stem cells. Theranostics. 2020;10:2817–31.

22.Sun Z, Gou W, Kim D, Dong X, Strange C, Tan Y, et al. Adipose Stem Cell Therapy Mitigates Chronic Pancreatitis via Differentiation into Acinar-like Cells in Mice. Mol Ther. 2017;25:2490–501.

23.Narsinh KH, Jia F, Robbins RC, Kay MA, Longaker MT, Wu JC. Generation of adult human induced pluripotent stem cells using nonviral minicircle DNA vectors. Nat Protoc. 2011;6:78–88.

24.Sugii S, Kida Y, Kawamura T, Suzuki J, Vassena R, Yin Y-Q, et al. Human and mouse adipose-derived cells support feeder-independent induction of pluripotent stem cells. Proc Natl Acad Sci U S A. 2010;107:3558–63.

25.Sun N, Panetta NJ, Gupta DM, Wilson KD, Lee A, Jia F, et al. Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells. PNAS. 2009;106:15720–5.

26.Sugii S, Kida Y, Berggren WT, Evans RM. Feeder-dependent and feeder-independent iPS cell derivation from human and mouse adipose stem cells. Nat Protoc. 2011;6:346–58.

27.Gnecchi M, Zhang Z, Ni A, Dzau VJ. Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy. Circ Res. 2008;103:1204–19.

28.Baraniak PR, McDevitt TC. Stem cell paracrine actions and tissue regeneration. Regen Med. 2010;5:121–43.

29.Kupcova SH. Proteomic techniques for characterisation of mesenchymal stem cell secretome. Biochimie. 2013;95:2196–211.

30.Bernardo ME, Fibbe WE. Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation. Cell Stem Cell. 2013;13:392–402.

31.Waterman RS, Tomchuck SL, Henkle SL, Betancourt AM. A New Mesenchymal Stem Cell (MSC) Paradigm: Polarization into a Pro-Inflammatory MSC1 or an Immunosuppressive MSC2 Phenotype. PLoS One. 2010;5:e10088.

32.González MA, Gonzalez-Rey E, Rico L, Büscher D, Delgado M. Adipose-Derived Mesenchymal Stem Cells Alleviate Experimental Colitis by Inhibiting Inflammatory and Autoimmune Responses. Gastroenterology. 2009;136:978–89.

33.Schweitzer KS, Johnstone BH, Garrison J, Rush NI, Cooper S, Traktuev DO, et al. Adipose Stem Cell Treatment in Mice Attenuates Lung and Systemic Injury Induced by Cigarette Smoking. Am J Respir Crit Care Med. 2011;183:215–25.

34.Gonzalez-Rey E, Anderson P, González MA, Rico L, Büscher D, Delgado M. Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis. Gut. 2009;58:929–39.

35.Furuhashi K, Tsuboi N, Shimizu A, Katsuno T, Kim H, Saka Y, et al. Serum-Starved Adipose-Derived Stromal Cells Ameliorate Crescentic GN by Promoting Immunoregulatory Macrophages. JASN. 2013;24:587–603.

36.Gonzalez-Rey E, Gonzalez MA, Varela N, O’Valle F, Hernandez-Cortes P, Rico L, et al. Human adipose-derived mesenchymal stem cells reduce inflammatory and T cell responses and induce regulatory T cells in vitro in rheumatoid arthritis. Ann Rheum Dis. 2010;69:241–8.

37.Anderson P, Souza-Moreira L, Morell M, Caro M, O’Valle F, Gonzalez-Rey E, et al. Adipose-derived mesenchymal stromal cells induce immunomodulatory macrophages which protect from experimental colitis and sepsis. Gut. 2013;62:1131–41.

38.Di Nicola M, Carlo-Stella C, Magni M, Milanesi M, Longoni PD, Matteucci P, et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood. 2002;99:3838–43.

39.Bartholomew A, Sturgeon C, Siatskas M, Ferrer K, McIntosh K, Patil S, et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol. 2002;30:42–8.

40.Blanc KL, Tammik L, Sundberg B, Haynesworth SE, Ringdén O. Mesenchymal Stem Cells Inhibit and Stimulate Mixed Lymphocyte Cultures and Mitogenic Responses Independently of the Major Histocompatibility Complex. Scand J Immunol. 2003;57:11–20.

41.Schneider M, Angele P, Järvinen TAH, Docheva D. Rescue plan for Achilles: Therapeutics steering the fate and functions of stem cells in tendon wound healing. Adv Drug Deliv Rev. 2018;129:352–75.

42.Bai X, Yan Y, Song Y-H, Seidensticker M, Rabinovich B, Metzele R, et al. Both cultured and freshly isolated adipose tissue-derived stem cells enhance cardiac function after acute myocardial infarction. Eur Heart J. 2010;31:489–501.

43.Mazo M, Planat-Bénard V, Abizanda G, Pelacho B, Léobon B, Gavira JJ, et al. Transplantation of adipose derived stromal cells is associated with functional improvement in a rat model of chronic myocardial infarction. Eur J Heart Fail. 2008;10:454–62.

44.Vazir A, Fox K, Westaby J, Evans MJ, Westaby S. Can we remove scar and fibrosis from adult human myocardium? Eur Heart J. 2019;40:960–6.

45.Tyndall A. Mesenchymal stem cell treatments in rheumatology—a glass half full? Nat Rev Rheumatol. 2014;10:117–24.

46.Castiglione F, Dewulf K, Hakim L, Weyne E, Montorsi F, Russo A, et al. Adipose-derived Stem Cells Counteract Urethral Stricture Formation in Rats. Eur Urol. 2016;70:1032–41.

47.Castiglione F, Hedlund P, Van der Aa F, Bivalacqua TJ, Rigatti P, Van Poppel H, et al. Intratunical Injection of Human Adipose Tissue–derived Stem Cells Prevents Fibrosis and Is Associated with Improved Erectile Function in a Rat Model of Peyronie’s Disease. Eur Urol. 2013;63:551–60.

48.Hillary CJ, Roman S, MacNeil S, Aicher WK, Stenzl A, Chapple CR. Regenerative medicine and injection therapies in stress urinary incontinence. Nature Reviews Urology. 2020;17:151–61.

49.Lin F. Adipose tissue–derived mesenchymal stem cells: a fat chance of curing kidney disease? Kidney Int. 2012;82:731–3.

50.Seki A, Sakai Y, Komura T, Nasti A, Yoshida K, Higashimoto M, et al. Adipose tissue-derived stem cells as a regenerative therapy for a mouse steatohepatitis-induced cirrhosis model. Hepatology. 2013;58:1133–42.

51.Tautenhahn H-M, Brückner S, Baumann S, Winkler S, Otto W, von Bergen M, et al. Attenuation of Postoperative Acute Liver Failure by Mesenchymal Stem Cell Treatment Due to Metabolic Implications. Ann Surg. 2016;263:546–56.

52.Koivusalo L, Kauppila M, Samanta S, Parihar VS, Ilmarinen T, Miettinen S, et al. Tissue adhesive hyaluronic acid hydrogels for sutureless stem cell delivery and regeneration of corneal epithelium and stroma. Biomaterials. 2019;225:119516.

53.Stonesifer C, Corey S, Ghanekar S, Diamandis Z, Acosta SA, Borlongan CV. Stem cell therapy for abrogating stroke-induced neuroinflammation and relevant secondary cell death mechanisms. Prog Neurobiol. 2017;158:94–131.

54.Lee S-T, Chu K, Jung K-H, Im W-S, Park J-E, Lim H-C, et al. Slowed progression in models of huntington disease by adipose stem cell transplantation. Ann Neurol. 2009;66:671–81.

55.Hu Y, Wu Y, Gou Z, Tao J, Zhang J, Liu Q, et al. 3D-engineering of Cellularized Conduits for Peripheral Nerve Regeneration. Sci Rep. 2016;6:32184.

56.Suh A, Pham A, Cress MJ, Pincelli T, TerKonda SP, Bruce AJ, et al. Adipose-derived cellular and cell-derived regenerative therapies in dermatology and aesthetic rejuvenation. Ageing Res Rev. 2019;54:100933.

57.Hu W, Jiang C, Guan D, Dierickx P, Zhang R, Moscati A, et al. Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response. Cell Stem Cell. 2019;24:299–308.e6.

58.Pas HIMFL, Moen MH, Haisma HJ, Winters M. No evidence for the use of stem cell therapy for tendon disorders: a systematic review. Br J Sports Med. 2017;51:996–1002.

59.Pas HI, Winters M, Haisma HJ, Koenis MJ, Tol JL, Moen MH. Stem cell injections in knee osteoarthritis: a systematic review of the literature. Br J Sports Med. 2017;51:1125–33.

60.Research C for BE and. Approved Cellular and Gene Therapy Products. FDA [Internet]. FDA; 2020 [cited 2020 Aug 20]; Available from: https://www.fda.gov/vaccines-blood-biologics/cellular-gene-therapy-products/approved-cellular-and-gene-therapy-products

61.Wei X, Yang X, Han Z, Qu F, Shao L, Shi Y. Mesenchymal stem cells: a new trend for cell therapy. Acta Pharmacol Sin. 2013;34:747–54.

62.Sharma RR, Pollock K, Hubel A, McKenna D. Mesenchymal stem or stromal cells: a review of clinical applications and manufacturing practices. Transfusion. 2014;54(5):1418–37.

63.Pittenger MF, Discher DE, Péault BM, Phinney DG, Hare JM, Caplan AI. Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ Regenerative medicine. 2019;4(1):1–15.

64.Kong Y, Ma B, Liu F, Chen D, Zhang S, Duan J, et al. Cellular Stemness Maintenance of Human Adipose-Derived Stem Cells on ZnO Nanorod Arrays. Small. 2019;15:1904099.

65.Bai T, Li J, Sinclair A, Imren S, Merriam F, Sun F, et al. Expansion of primitive human hematopoietic stem cells by culture in a zwitterionic hydrogel. Nat Med. 2019;25:1566–75.

66.Dong D, Hao T, Wang C, Zhang Y, Qin Z, Yang B, et al. Zwitterionic starch-based hydrogel for the expansion and “stemness” maintenance of brown adipose derived stem cells. Biomaterials. 2018;157:149–60.

67.Zhang R, Luo W, Zhang Y, Zhu D, Midgley AC, Song H, et al. Particle-based artificial three-dimensional stem cell spheroids for revascularization of ischemic diseases. Sci Adv. 2020;6:eaaz8011.

68.Seo J, Lee JS, Lee K, Kim D, Yang K, Shin S, et al. Switchable Water-Adhesive, Superhydrophobic Palladium-Layered Silicon Nanowires Potentiate the Angiogenic Efficacy of Human Stem Cell Spheroids. Adv Mater. 2014;26:7043–50.

69.Kim S, Park J, Byun H, Park Y-W, Major LG, Lee DY, et al. Hydrogels with an embossed surface: An all-in-one platform for mass production and culture of human adipose-derived stem cell spheroids. Biomaterials. 2019;188:198–212.

70.Kim S, Park J, Kim EM, Choi J-J, Kim H-N, Chin IL, et al. Lotus seedpod-inspired hydrogels as an all-in-one platform for culture and delivery of stem cell spheroids. Biomaterials. 2019;225:119534.

71.He Q, Liao Y, Zhang J, Yao X, Zhou W, Hong Y, et al. “All-in-One” Gel System for Whole Procedure of Stem-Cell Amplification and Tissue Engineering. Small. 2020;16:1906539.

72.Jiang T, Liu W, Lv X, Sun H, Zhang L, Liu Y, et al. Potent in vitro chondrogenesis of CD105 enriched human adipose-derived stem cells. Biomaterials. 2010;31:3564–71.

73.Cheifetz S, Bellón T, Calés C, Vera S, Bernabeu C, Massagué J, et al. Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. J Biol Chem. 1992;267:19027–30.

74.Li X, Guo W, Zha K, Jing X, Wang M, Zhang Y, et al. Enrichment of CD146+ Adipose-Derived Stem Cells in Combination with Articular Cartilage Extracellular Matrix Scaffold Promotes Cartilage Regeneration. Theranostics. 2019;9:5105–21.

75.Guo Y, Wang H, Huang L, Ou L, Zhu J, Liu S, et al. Small extracellular vesicles-based cell-free strategies for therapy. MedComm. 2021;2:17–26.

76.Lai RC, Chen TS, Lim SK. Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease. Regen Med. 2011;6:481–92.

77.Jung YJ, Kim HK, Cho Y, Choi JS, Woo CH, Lee KS, et al. Cell reprogramming using extracellular vesicles from differentiating stem cells into white/beige adipocytes. Sci Adv. 2020;6:eaay6721.

78.Woo CH, Kim HK, Jung GY, Jung YJ, Lee KS, Yun YE, et al. Small extracellular vesicles from human adipose-derived stem cells attenuate cartilage degeneration. Journal of Extracellular Vesicles. 2020;9:1735249.

79.Choi JS, Cho WL, Choi YJ, Kim JD, Park H-A, Kim SY, et al. Functional recovery in photo-damaged human dermal fibroblasts by human adipose-derived stem cell extracellular vesicles. Journal of Extracellular Vesicles. 2019;8:1565885.

80.Eirin A, Zhu X-Y, Puranik AS, Tang H, McGurren KA, van Wijnen AJ, et al. Mesenchymal stem cell-derived extracellular vesicles attenuate kidney inflammation. Kidney Int. 2017;92:114–24.

81.Chen L, Mou S, Li F, Zeng Y, Sun Y, Horch RE, et al. Self-Assembled Human Adipose-Derived Stem Cell-Derived Extracellular Vesicle-Functionalized Biotin-Doped Polypyrrole Titanium with Long-Term Stability and Potential Osteoinductive Ability. ACS Appl Mater Interfaces. 2019;11:46183–96.

82.Théry C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol. 2009;9:581–93.

83.Andaloussi SEL, Mäger I, Breakefield XO, Wood MJA. Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov. 2013;12:347–57.

84.Li W, Liu Y, Zhang P, Tang Y, Zhou M, Jiang W, et al. Tissue-Engineered Bone Immobilized with Human Adipose Stem Cells-Derived Exosomes Promotes Bone Regeneration. ACS Appl Mater Interfaces. 2018;10:5240–54.

85.Wang C, Wang M, Xu T, Zhang X, Lin C, Gao W, et al. Engineering Bioactive Self-Healing Antibacterial Exosomes Hydrogel for Promoting Chronic Diabetic Wound Healing and Complete Skin Regeneration. Theranostics. 2019;9:65–76.

86.Shiekh PA, Singh A, Kumar A. Exosome laden oxygen releasing antioxidant and antibacterial cryogel wound dressing OxOBand alleviate diabetic and infectious wound healing. Biomaterials. 2020;249:120020.

87.Cao Y. Monotherapy Versus Combination Therapy of Angiogenic and Arteriogenic Factors for the Treatment of Ischemic Disorders. Curr Mol Med. 2009;9:967–72.

88.Xia X, Chan KF, Wong GTY, Wang P, Liu L, Yeung BPM, et al. Mesenchymal stem cells promote healing of nonsteroidal anti-inflammatory drug-related peptic ulcer through paracrine actions in pigs. Sci Transl Med. 2019;11:eaat7455.

89.Su N, Gao P-L, Wang K, Wang J-Y, Zhong Y, Luo Y. Fibrous scaffolds potentiate the paracrine function of mesenchymal stem cells: A new dimension in cell-material interaction. Biomaterials. 2017;141:74–85.

90.Li T, Ma H, Ma H, Ma Z, Qiang L, Yang Z, et al. Mussel-Inspired Nanostructures Potentiate the Immunomodulatory Properties and Angiogenesis of Mesenchymal Stem Cells. ACS Appl Mater Interfaces. 2019;11:17134–46.

91.Wang X, Zhang J, Cui W, Fang Y, Li L, Ji S, et al. Composite Hydrogel Modified by IGF-1C Domain Improves Stem Cell Therapy for Limb Ischemia. ACS Appl Mater Interfaces. 2018;10:4481–93.

92.Han D, Huang W, Li X, Gao L, Su T, Li X, et al. Melatonin facilitates adipose-derived mesenchymal stem cells to repair the murine infarcted heart via the SIRT1 signaling pathway. J Pineal Res. 2016;60:178–92.

93.Wang WE, Yang D, Li L, Wang W, Peng Y, Chen C, et al. Prolyl Hydroxylase Domain Protein 2 Silencing Enhances the Survival and Paracrine Function of Transplanted Adipose-Derived Stem Cells in Infarcted Myocardium. Circ Res. 2013;113:288–300.

94.Hu X, Wu R, Jiang Z, Wang L, Chen P, Zhang L, et al. Leptin Signaling Is Required for Augmented Therapeutic Properties of Mesenchymal Stem Cells Conferred by Hypoxia Preconditioning: Leptin Required for MSC Hypoxic Preconditioning. Stem Cells. 2014;32:2702–13.

95.Chen L, Xing Q, Zhai Q, Tahtinen M, Zhou F, Chen L, et al. Pre-vascularization Enhances Therapeutic Effects of Human Mesenchymal Stem Cell Sheets in Full Thickness Skin Wound Repair. Theranostics. 2017;7:117–31.

96.Madonna R, Taylor DA, Geng Y-J, De Caterina R, Shelat H, Perin EC, et al. Transplantation of Mesenchymal Cells Rejuvenated by the Overexpression of Telomerase and Myocardin Promotes Revascularization and Tissue Repair in a Murine Model of Hindlimb Ischemia. Circ Res. 2013;113:902–14.

97.Liang C, Liu Z, Song M, Li W, Wu Z, Wang Z, et al. Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration. Cell Res. 2021;31:187–205.

98.Lin C-Y, Chang Y-H, Li K-C, Lu C-H, Sung L-Y, Yeh C-L, et al. The use of ASCs engineered to express BMP2 or TGF-β3 within scaffold constructs to promote calvarial bone repair. Biomaterials. 2013;34:9401–12.

99.Lu C-H, Yeh T-S, Yeh C-L, Fang Y-HD, Sung L-Y, Lin S-Y, et al. Regenerating Cartilages by Engineered ASCs: Prolonged TGF-β3/BMP-6 Expression Improved Articular Cartilage Formation and Restored Zonal Structure. Mol Ther. 2014;22:186–95.

100.Sung L-Y, Chen C-L, Lin S-Y, Li K-C, Yeh C-L, Chen G-Y, et al. Efficient gene delivery into cell lines and stem cells using baculovirus. Nat Protoc. 2014;9:1882–99.

101.Hsu M-N, Yu F-J, Chang Y-H, Huang K-L, Pham NN, Truong VA, et al. CRISPR interference-mediated noggin knockdown promotes BMP2-induced osteogenesis and calvarial bone healing. Biomaterials. 2020;252:120094.

102.Xie Q, Wang Z, Zhou H, Yu Z, Huang Y, Sun H, et al. The role of miR-135-modified adipose-derived mesenchymal stem cells in bone regeneration. Biomaterials. 2016;75:279–94.

103.Huang Q, Zou Y, Arno MC, Chen S, Wang T, Gao J, et al. Hydrogel scaffolds for differentiation of adipose-derived stem cells. Chem Soc Rev. 2017;46:6255–75.

104.Wen JH, Vincent LG, Fuhrmann A, Choi YS, Hribar KC, Taylor-Weiner H, et al. Interplay of matrix stiffness and protein tethering in stem cell differentiation. Nat Mater. 2014;13:979–87.

105.Hadden WJ, Young JL, Holle AW, McFetridge ML, Kim DY, Wijesinghe P, et al. Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels. Proc Natl Acad Sci U S A. 2017;114:5647–52.

106.Huebsch N, Arany PR, Mao AS, Shvartsman D, Ali OA, Bencherif SA, et al. Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate. Nat Mater. 2010;9:518–26.

107.Liu Y, Li Z, Li J, Yang S, Zhang Y, Yao B, et al. Stiffness-mediated mesenchymal stem cell fate decision in 3D-bioprinted hydrogels. Burns Trauma. 2020;8:tkaa029.

108.Kilian KA, Bugarija B, Lahn BT, Mrksich M. Geometric cues for directing the differentiation of mesenchymal stem cells. Proc Natl Acad Sci. 2010;107:4872–7.

109.Jeon O, Alsberg E. Regulation of Stem Cell Fate in a Three-Dimensional Micropatterned Dual-Crosslinked Hydrogel System. Adv Funct Mater. 2013;23:4765–75.

110.Lee J, Abdeen AA, Zhang D, Kilian KA. Directing stem cell fate on hydrogel substrates by controlling cell geometry, matrix mechanics and adhesion ligand composition. Biomaterials. 2013;34:8140–8.

111.Khetan S, Guvendiren M, Legant WR, Cohen DM, Chen CS, Burdick JA. Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels. Nat Mater. 2013;12:458–65.

112.Major LG, Holle AW, Young JL, Hepburn MS, Jeong K, Chin IL, et al. Volume Adaptation Controls Stem Cell Mechanotransduction. ACS Appl Mater Interfaces. 2019;11:45520–30.

113.Mahmoudi M, Bonakdar S, Shokrgozar MA, Aghaverdi H, Hartmann R, Pick A, et al. Cell-Imprinted Substrates Direct the Fate of Stem Cells. ACS Nano. 2013;7:8379–84.

114.Murphy WL, McDevitt TC, Engler AJ. Materials as stem cell regulators. Nat Mater. 2014;13:547–57.

115.Sun Y, Gao Z, Zhang X, Xu Z, Zhang Y, He B, et al. 3D-printed, bi-layer, biomimetic artificial periosteum for boosting bone regeneration. Bio-des Manuf. 2022;1–16.

116.Khatua C, Min S, Jung HJ, Shin JE, Li N, Jun I, et al. In Situ Magnetic Control of Macroscale Nanoligand Density Regulates the Adhesion and Differentiation of Stem Cells. Nano Lett. 2020;20:4188–96.

117.Lee J, Jeon O, Kong M, Abdeen AA, Shin J-Y, Lee HN, et al. Combinatorial screening of biochemical and physical signals for phenotypic regulation of stem cell–based cartilage tissue engineering. Sci Adv. 2020;6:eaaz5913.

118.Hao M, He J, Wang C, Wang C, Ma B, Zhang S, et al. Effect of Hydroxyapatite Nanorods on the Fate of Human Adipose-Derived Stem Cells Assessed In Situ at the Single Cell Level with a High-Throughput, Real-Time Microfluidic Chip. Small. 2019;15:1905001.

119.Wu X, Schneider N, Platen A, Mitra I, Blazek M, Zengerle R, et al. In situ characterization of the mTORC1 during adipogenesis of human adult stem cells on chip. Proc Natl Acad Sci U S A. 2016;113:E4143–50.

120.Srifa W, Kosaric N, Amorin A, Jadi O, Park Y, Mantri S, et al. Cas9-AAV6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice. Nat Commun. 2020;11:2470.

121.Hsu M-N, Liao H-T, Truong VA, Huang K-L, Yu F-J, Chen H-H, et al. CRISPR-based Activation of Endogenous Neurotrophic Genes in Adipose Stem Cell Sheets to Stimulate Peripheral Nerve Regeneration. Theranostics. 2019;9:6099–111.

122.Leong J, Hong Y-T, Wu Y-F, Ko E, Dvoretskiy S, Teo JY, et al. Surface Tethering of Inflammation-Modulatory Nanostimulators to Stem Cells for Ischemic Muscle Repair. ACS Nano. 2020;14:5298–313.

123.Miyahara Y, Nagaya N, Kataoka M, Yanagawa B, Tanaka K, Hao H, et al. Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. Nat Med. 2006;12:459–65.

124.Sousa AR, Martins-Cruz C, Oliveira MB, Mano JF. One-Step Rapid Fabrication of Cell-Only Living Fibers. Adv Mater. 2020;32:1906305.

125.Thomas D, Marsico G, Mohd Isa IL, Thirumaran A, Chen X, Lukasz B, et al. Temporal changes guided by mesenchymal stem cells on a 3D microgel platform enhance angiogenesis in vivo at a low-cell dose. Proc Natl Acad Sci U S A. 2020;117:19033–44.

126.Li Y, Liu W, Liu F, Zeng Y, Zuo S, Feng S, et al. Primed 3D injectable microniches enabling low-dosage cell therapy for critical limb ischemia. Proc Natl Acad Sci U S A. 2014;111:13511–6.

127.Wan S, Fu X, Ji Y, Li M, Shi X, Wang Y. FAK- and YAP/TAZ dependent mechanotransduction pathways are required for enhanced immunomodulatory properties of adipose-derived mesenchymal stem cells induced by aligned fibrous scaffolds. Biomaterials. 2018;171:107–17.

128.Bandaru P, Cefaloni G, Vajhadin F, Lee K, Kim H-J, Cho H-J, et al. Mechanical Cues Regulating Proangiogenic Potential of Human Mesenchymal Stem Cells through YAP-Mediated Mechanosensing. Small. 2020;16:2001837.

129.Yao X, Liu Y, Gao J, Yang L, Mao D, Stefanitsch C, et al. Nitric oxide releasing hydrogel enhances the therapeutic efficacy of mesenchymal stem cells for myocardial infarction. Biomaterials. 2015;60:130–40.

130.Fu X-B. Repair cell first, then regenerate the tissues and organs. Military Medical Research. 2021;8:2.

131.Liu Z, Wang H, Wang Y, Lin Q, Yao A, Cao F, et al. The influence of chitosan hydrogel on stem cell engraftment, survival and homing in the ischemic myocardial microenvironment. Biomaterials. 2012;33:3093–106.

132.Hao T, Li J, Yao F, Dong D, Wang Y, Yang B, et al. Injectable Fullerenol/Alginate Hydrogel for Suppression of Oxidative Stress Damage in Brown Adipose-Derived Stem Cells and Cardiac Repair. ACS Nano. 2017;11:5474–88.

133.Laschke MW, Menger MD. Prevascularization in tissue engineering: Current concepts and future directions. Biotechnol Adv. 2016;34:112–21.

134.Gilbert-Honick J, Iyer SR, Somers SM, Lovering RM, Wagner K, Mao H-Q, et al. Engineering functional and histological regeneration of vascularized skeletal muscle. Biomaterials. 2018;164:70–9.

135.Kim BS, Kwon YW, Kong J-S, Park GT, Gao G, Han W, et al. 3D cell printing of in vitro stabilized skin model and in vivo pre-vascularized skin patch using tissue-specific extracellular matrix bioink: A step towards advanced skin tissue engineering. Biomaterials. 2018;168:38–53.

136.Du J, Xie P, Lin S, Wu Y, Zeng D, Li Y, et al. Time-Phase Sequential Utilization of Adipose-Derived Mesenchymal Stem Cells on Mesoporous Bioactive Glass for Restoration of Critical Size Bone Defects. ACS Appl Mater Interfaces. 2018;10:28340–50.

137.Kimelman-Bleich N, Pelled G, Sheyn D, Kallai I, Zilberman Y, Mizrahi O, et al. The use of a synthetic oxygen carrier-enriched hydrogel to enhance mesenchymal stem cell-based bone formation in vivo. Biomaterials. 2009;30:4639–48.

138.Imanishi Y, Saito A, Komoda H, Kitagawa-Sakakida S, Miyagawa S, Kondoh H, et al. Allogenic mesenchymal stem cell transplantation has a therapeutic effect in acute myocardial infarction in rats. J Mol Cell Cardiol. 2008;44:662–71.

139.Moll G, Ankrum JA, Kamhieh-Milz J, Bieback K, Ringdén O, Volk H-D, et al. Intravascular Mesenchymal Stromal/Stem Cell Therapy Product Diversification: Time for New Clinical Guidelines. Trends Mol Med. 2019;25:149–63.

140.Kim JC, Tae G. The modulation of biodistribution of stem cells by anchoring lipid-conjugated heparin on the cell surface. J Control Release. 2015;217:128–37.

141.Hwang Y, Kim JC, Tae G. Significantly enhanced recovery of acute liver failure by liver targeted delivery of stem cells via heparin functionalization. Biomaterials. 2019;209:67–78.

142.Hwang Y, Goh M, Kim M, Tae G. Injectable and detachable heparin-based hydrogel micropatches for hepatic differentiation of hADSCs and their liver targeted delivery. Biomaterials. 2018;165:94–104.

143.Hu C-MJ, Zhang L, Aryal S, Cheung C, Fang RH, Zhang L. Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform. Proc Natl Acad Sci. 2011;108:10980–5.

144.Hu C-MJ, Fang RH, Wang K-C, Luk BT, Thamphiwatana S, Dehaini D, et al. Nanoparticle biointerfacing by platelet membrane cloaking. Nature. 2015;526:118–21.

145.Abbott JD, Huang Y, Liu D, Hickey R, Krause DS, Giordano FJ. Stromal Cell–Derived Factor-1α Plays a Critical Role in Stem Cell Recruitment to the Heart After Myocardial Infarction but Is Not Sufficient to Induce Homing in the Absence of Injury. Circulation. 2004;110:3300–5.

146.Ng NN, Thakor AS. Locoregional delivery of stem cell–based therapies. Sci Transl Med. 2020;12:eaba4564.

147.Silva AKA, Perretta S, Perrod G, Pidial L, Lindner V, Carn F, et al. Thermoresponsive Gel Embedded with Adipose Stem-Cell-Derived Extracellular Vesicles Promotes Esophageal Fistula Healing in a Thermo-Actuated Delivery Strategy. ACS Nano. 2018;12:9800–14.

148.Chen Y, Zhang J, Liu X, Wang S, Tao J, Huang Y, et al. Noninvasive in vivo 3D bioprinting. Sci Adv. 2020;6:eaba7406.

149.He P, et al. Bioprinting of skin constructs for wound healing. Burns & trauma. 2018;6. https://doi.org/10.1186/s41038-017-0104-x.

150.Zhang L, et al. Novel pneumatically assisted atomization device for living cell delivery: Application of sprayed mesenchymal stem cells for skin regeneration. Bio-Design and Manufacturing. 2022;5.1:220–32.

151.Clark AY, Martin KE, García JR, Johnson CT, Theriault HS, Han WM, et al. Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities. Nat Commun. 2020;11:114.

152.Liang W, Chen J, Li L, Li M, Wei X, Tan B, et al. Conductive Hydrogen Sulfide-Releasing Hydrogel Encapsulating ADSCs for Myocardial Infarction Treatment. ACS Appl Mater Interfaces. 2019;11:14619–29.

153.Yan W, Lin C, Guo Y, Chen Y, Du Y, Lau WB, et al. N-Cadherin Overexpression Mobilizes the Protective Effects of Mesenchymal Stromal Cells Against Ischemic Heart Injury Through a β-Catenin–Dependent Manner. Circ Res. 2020;126:857–74.

154.Yang J, Yamato M, Nishida K, Ohki T, Kanzaki M, Sekine H, et al. Cell delivery in regenerative medicine: The cell sheet engineering approach. J Control Release. 2006;116:193–203.

155.Yamato M, Utsumi M, Kushida A, Konno C, Kikuchi A, Okano T. Thermo-Responsive Culture Dishes Allow the Intact Harvest of Multilayered Keratinocyte Sheets without Dispase by Reducing Temperature. Tissue Eng. 2001;7:473–80.

156.Hong Y, Chen J, Fang H, Li G, Yan S, Zhang K, et al. All-in-One Hydrogel Realizing Adipose-Derived Stem Cell Spheroid Production and In Vivo Injection via “Gel–Sol” Transition for Angiogenesis in Hind Limb Ischemia. ACS Appl Mater Interfaces. 2020;12:11375–87.

157.Liu X, et al. 3D printing enabled customization of functional microgels. ACS applied materials & interfaces. 2019;11.13:12209–215.

158.Lee J-R, Park B-W, Kim J, Choo YW, Kim HY, Yoon J-K, et al. Nanovesicles derived from iron oxide nanoparticles–incorporated mesenchymal stem cells for cardiac repair. Sci Adv. 2020;6:eaaz0952.

159.Taki Z, Gostjeva E, Thilly W, Yaseen B, Lopez H, Mirza M, et al. Pathogenic Activation of Mesenchymal Stem Cells Is Induced by the Disease Microenvironment in Systemic Sclerosis. Arthritis & Rheumatology. 2020;72:1361–74.

160.Kizilay Mancini O, Lora M, Cuillerier A, Shum-Tim D, Hamdy R, Burelle Y, et al. Mitochondrial Oxidative Stress Reduces the Immunopotency of Mesenchymal Stromal Cells in Adults With Coronary Artery Disease. Circ Res. 2018;122:255–66.

161.Cianfarani F, Toietta G, Rocco GD, Cesareo E, Zambruno G, Odorisio T. Diabetes impairs adipose tissue–derived stem cell function and efficiency in promoting wound healing. Wound Repair Regen. 2013;21:545–53.

162.Louwen F, Ritter A, Kreis NN, Yuan J. Insight into the development of obesity: functional alterations of adipose-derived mesenchymal stem cells. Obes Rev. 2018;19:888–904.

163.Ritter A, Louwen F, Yuan J. Deficient primary cilia in obese adipose-derived mesenchymal stem cells: obesity, a secondary ciliopathy? Obes Rev. 2018;19:1317–28.

164.Aird AL, Nevitt CD, Christian K, Williams SK, Hoying JB, LeBlanc AJ. Adipose-derived stromal vascular fraction cells isolated from old animals exhibit reduced capacity to support the formation of microvascular networks. Exp Gerontol. 2015;63:18–26.

165.Álvaro-Gracia JM, Jover JA, García-Vicuña R, Carreño L, Alonso A, Marsal S, et al. Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis (Cx611): results of a multicentre, dose escalation, randomised, single-blind, placebo-controlled phase Ib/IIa clinical trial. Ann Rheum Dis. 2017;76:196–202.

166.Liang J, Zhang H, Hua B, Wang H, Lu L, Shi S, et al. Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study. Ann Rheum Dis. 2010;69:1423–9.

167.Bartolucci J, Verdugo FJ, González PL, Larrea RE, Abarzua E, Goset C, et al. Safety and Efficacy of the Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Patients With Heart Failure: A Phase 1/2 Randomized Controlled Trial (RIMECARD Trial [Randomized Clinical Trial of Intravenous Infusion Umbilical Cord Mesenchymal Stem Cells on Cardiopathy]). Circ Res. 2017;121:1192–204.

168.Vagnozzi RJ, Maillet M, Sargent MA, Khalil H, Johansen AKZ, Schwanekamp JA, et al. An acute immune response underlies the benefit of cardiac stem cell therapy. Nature. 2020;577:405–9.

169.Fu Y, Sui B, Xiang L, Yan X, Wu D, Shi S, et al. Emerging understanding of apoptosis in mediating mesenchymal stem cell therapy. Cell Death Dis. 2021;12:1–12.

170.Packer M. The Alchemist’s Nightmare: Might Mesenchymal Stem Cells That Are Recruited to Repair the Injured Heart Be Transformed Into Fibroblasts Rather Than Cardiomyocytes? Circulation. 2018;137:2068–73.

171.von Bahr L, Batsis I, Moll G, Hägg M, Szakos A, Sundberg B, et al. Analysis of Tissues Following Mesenchymal Stromal Cell Therapy in Humans Indicates Limited Long-Term Engraftment and No Ectopic Tissue Formation. Stem Cells. 2012;30:1575–8.

172.Dai S, Wei D, Wu Z, Zhou X, Wei X, Huang H, et al. Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer. Mol Ther. 2008;16:782–90.

173.Vulliet PR, Greeley M, Halloran SM, MacDonald KA, Kittleson MD. Intra-coronary arterial injection of mesenchymal stromal cells and microinfarction in dogs. Lancet. 2004;363:783–4.

174.Tarte K, Gaillard J, Lataillade J-J, Fouillard L, Becker M, Mossafa H, et al. Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation. Blood. 2010;115:1549–53.

175.Hacein-Bey-Abina S, Garrigue A, Wang GP, Soulier J, Lim A, Morillon E, et al. Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J Clin Invest. 2008;118:3132–42.

176.Fu Y, Foden JA, Khayter C, Maeder ML, Reyon D, Joung JK, et al. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nat Biotechnol. 2013;31:822–6.

177.Talukdar Y, Rashkow JT, Lalwani G, Kanakia S, Sitharaman B. The effects of graphene nanostructures on mesenchymal stem cells. Biomaterials. 2014;35:4863–77.

178.Ning H, Yang F, Jiang M, Hu L, Feng K, Zhang J, et al. The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: outcome of a pilot clinical study. Leukemia. 2008;22:593–9.

179.Chandler EM, Seo BR, Califano JP, Andresen Eguiluz RC, Lee JS, Yoon CJ, et al. Implanted adipose progenitor cells as physicochemical regulators of breast cancer. Proc Natl Acad Sci. 2012;109:9786–91.

180.Bianco P. Don’t market stem-cell products ahead of proof. Nature News. 2013;499:255.

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