Challenges and innovations in treating chronic and acute wound infections: from basic science to clinical practice

Xiaotong Ding; Qinghan Tang; Zeyu Xu; Ye Xu; Hao Zhang; Dongfeng Zheng; Shuqin Wang; Qian Tan; Joanneke Maitz; Peter K Maitz; Shaoping Yin; Yiwei Wang; Jun Chen

doi:10.1093/burnst/tkac014

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Challenges and innovations in treating chronic and acute wound infections: from basic science to clinical practice

更新时间：2022-06-09

- Challenges and innovations in treating chronic and acute wound infections: from basic science to clinical practice
- Challenges and innovations in treating chronic and acute wound infections: from basic science to clinical practice
- Burns & Trauma 2022年10卷第1期
- 作者机构：
  
  1. School of Pharmacy
  2. Nanjing University of Chinese Medicine
  3. Department of Burns and Plastic Surgery, The affiliated Drum Tow Hospital of Nanjing University of Chinese Medicine
  4. Burns Injury and Reconstructive Surgery Research
  5. University of Sydney
  6. Burns Unit, Concord Repatriation General Hospital
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkac014
  中图分类号：
- 纸质出版日期：2022，
  
  网络出版日期：2022-5-21，
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Challenges and innovations in treating chronic and acute wound infections: from basic science to clinical practice[J]. Burns & Trauma, 2022,10(1).

Xiaotong Ding, Qinghan Tang, Zeyu Xu, Ye Xu, Hao Zhang, Dongfeng Zheng, Shuqin Wang, Qian Tan, Joanneke Maitz, Peter K Maitz, Shaoping Yin, Yiwei Wang, Jun Chen, Challenges and innovations in treating chronic and acute wound infections: from basic science to clinical practice, Burns & Trauma, Volume 10, 2022, tkac014, https://doi.org/10.1093/burnst/tkac014
Challenges and innovations in treating chronic and acute wound infections: from basic science to clinical practice[J]. Burns & Trauma, 2022,10(1). DOI： 10.1093/burnst/tkac014.

Xiaotong Ding, Qinghan Tang, Zeyu Xu, Ye Xu, Hao Zhang, Dongfeng Zheng, Shuqin Wang, Qian Tan, Joanneke Maitz, Peter K Maitz, Shaoping Yin, Yiwei Wang, Jun Chen, Challenges and innovations in treating chronic and acute wound infections: from basic science to clinical practice, Burns & Trauma, Volume 10, 2022, tkac014, https://doi.org/10.1093/burnst/tkac014 DOI：

摘要

Abstract

Acute and chronic wound infection has become a major worldwide healthcare burden leading to significantly high morbidity and mortality. The underlying mechanism of infections has been widely investigated by scientist

while standard wound management is routinely been used in general practice. However

strategies for the diagnosis and treatment of wound infections remain a great challenge due to the occurrence of biofilm colonization

delayed healing and drug resistance. In the present review

we summarize the common microorganisms found in acute and chronic wound infections and discuss the challenges from the aspects of clinical diagnosis

non-surgical methods and surgical methods. Moreover

we highlight emerging innovations in the development of antimicrobial peptides

phages

controlled drug delivery

wound dressing materials and herbal medicine

and find that sensitive diagnostics

combined treatment and skin microbiome regulation could be future directions in the treatment of wound infection.

关键词

Keywords

Wound infectionsSkin microbiomeDiagnosisAntimicrobial wound dressingsHerbal medicineHydrogelsAntimicrobial peptidesPhagesDrug delivery

references

1.Parani M, Lokhande G, Singh A, Gaharwar AK. Engineered nanomaterials for infection control and healing acute and chronic wounds. ACS Appl Mater Interfaces. 2016;8:10049–69.

2.Fan Z, Yao B, Ding Y, Xu D, Zhao J, Zhang K. Rational engineering the DNA tetrahedrons of dual wavelength ratiometric electrochemiluminescence biosensor for high efficient detection of SARS-CoV-2 RdRp gene by using entropy-driven and bipedal DNA walker amplification strategy. Chem Eng J. 2022;427:131686. https://doi.org/10.1016/j.cej.2021.131686.

3.Bassetti M, Peghin M, Castaldo N, Giacobbe DR. The safety of treatment options for acute bacterial skin and skin structure infections. Expert Opin Drug Saf. 2019;18:635–50.

4.Jamaledin R, Yiu CKY, Zare EN, Niu LN, Vecchione R, Chen G, et al. Advances in antimicrobial microneedle patches for combating infections. Adv Mater. 2020;32:e2002129. https://doi.org/10.1002/adma.202002129.

5.Rahim K, Saleha S, Zhu X, Huo L, Basit A, Franco OL. Bacterial contribution in chronicity of wounds. Microb Ecol. 2017;73:710–21.

6.Turner KH, Everett J, Trivedi U, Rumbaugh KP, Whiteley M. Requirements for Pseudomonas aeruginosa acute burn and chronic surgical wound infection. PLoS Genet. 2014;10:e1004518. https://doi.org/10.1371/journal.pgen.1004518.

7.Norman G, Christie J, Liu Z, Westby MJ, Jefferies JM, Hudson T, et al. Antiseptics for burns. Cochrane Database Syst Rev. 2017;7:CD011821. https://doi.org/10.1002/14651858.CD011821.pub2.

8.Wang Y, Beekman J, Hew J, Jackson S, Issler-Fisher AC, Parungao R, et al. Burn injury: challenges and advances in burn wound healing, infection, pain and scarring. Adv Drug Deliv Rev. 2018;123:3–17.

9.Sganga G, Pea F, Aloj D, Corcione S, Pierangeli M, Stefani S, et al. Acute wound infections management: the 'Don'ts' from a multidisciplinary expert panel. Expert Rev Anti-Infect Ther. 2020;18:231–40.

10.Reid G, Younes JA, Van der Mei HC, Gloor GB, Knight R, Busscher HJ. Microbiota restoration: natural and supplemented recovery of human microbial communities. Nat Rev Microbiol. 2011;9:27–38.

11.Branch-Elliman W, Ripollone JE, O'Brien WJ, Itani KMF, Schweizer ML, Perencevich E, et al. Risk of surgical site infection, acute kidney injury, and Clostridium difficile infection following antibiotic prophylaxis with vancomycin plus a beta-lactam versus either drug alone: a national propensity-score-adjusted retrospective cohort study. PLoS Med. 2017;14:e1002340. https://doi.org/10.1371/journal.pmed.1002340.

12.Altoparlak U, Koca O, Ozkurt Z, Akcay MN. Incidence and risk factors of vancomycin-resistant enterococcus colonization in burn unit patients. Burns. 2011;37:49–53.

13.Costa ML, Achten J, Knight R, Bruce J, Dutton SJ, Madan J, et al. Effect of incisional negative pressure wound therapy vs standard wound dressing on deep surgical site infection after surgery for lower limb fractures associated with major trauma: the WHIST randomized clinical trial. JAMA. 2020;323:519–26.

14.Heal CF, Banks JL, Lepper PD, Kontopantelis E, van Driel ML. Topical antibiotics for preventing surgical site infection in wounds healing by primary intention. Cochrane Database Syst Rev. 2016;11:CD011426. https://doi.org/10.1002/14651858.CD011426.pub2.

15.O'Neal PB, Itani KM. Antimicrobial formulation and delivery in the prevention of surgical site infection. Surg Infect. 2016;17:275–85.

16.Cooper C, Horner C, Barlow G, Stryja J, Sandy-Hodgetts K, Guise T, et al. A survey of practice and opinions on the use of topical antibiotics to prevent surgical site infection: more confusion than consensus. J Antimicrob Chemother. 2018;73:1978–83.

17.Mihai MM, Holban AM, Giurcaneanu C, Popa LG, Oanea RM, Lazar V, et al. Microbial biofilms: impact on the pathogenesis of periodontitis, cystic fibrosis, chronic wounds and medical device-related infections. Curr Top Med Chem. 2015;15:1552–76.

18.Percival SL. Importance of biofilm formation in surgical infection. Br J Surg. 2017;104:e85–94.

19.Iheozor-Ejiofor Z, Newton K, Dumville JC, Costa ML, Norman G, Bruce J, et al. Negative pressure wound therapy for open traumatic wounds. Cochrane Database Syst Rev. 2018;2018:CD012522. https://doi.org/10.1002/14651858.CD012522.pub2.

20.Dai T, Kharkwal GB, Tanaka M, Huang YY, Bil de Arce VJ, Hamblin MR. Animal models of external traumatic wound infections. Virulence. 2011;2:296–315.

21.Singer AJ, Dagum AB. Current management of acute cutaneous wounds. N Engl J Med. 2008;359:1037–46.

22.Herrod PJ, Boyd-Carson H, Doleman B, Blackwell J, Williams JP, Bhalla A, et al. Prophylactic antibiotics for penetrating abdominal trauma: duration of use and antibiotic choice. Cochrane Database Syst Rev. 2019;12:CD010808. https://doi.org/10.1002/14651858.CD010808.pub2.

23.Ganesan A, Shaikh F, Bradley W, Blyth DM, Bennett D, Petfield JL, et al. Classification of trauma-associated invasive fungal infections to support wound treatment decisions. Emerg Infect Dis. 2019;25. https://doi.org/10.3201/eid2509.190168.

24.Kronen R, Liang SY, Bochicchio G, Bochicchio K, Powderly WG, Spec A. Invasive fungal infections secondary to traumatic injury. Int J Infect Dis. 2017;62:102–11.

25.Warkentien T, Rodriguez C, Lloyd B, Wells J, Weintrob A, Dunne JR, et al. Invasive mold infections following combat-related injuries. Clin Infect Dis. 2012;55:1441–9.

26.Tomic-Canic M, Burgess JL, O'Neill KE, Strbo N, Pastar I. Skin microbiota and its interplay with wound healing. Am J Clin Dermatol. 2020;21:36–43.

27.Kalan L, Loesche M, Hodkinson BP, Heilmann K, Ruthel G, Gardner SE, et al. Redefining the chronic-wound microbiome: fungal communities are prevalent, dynamic, and associated with delayed healing. M bio. 2016;7. https://doi.org/10.1128/mBio.01058-16.

28.Di Domenico EG, Farulla I, Prignano G, Gallo MT, Vespaziani M, Cavallo I, et al. Biofilm is a major virulence determinant in bacterial colonization of chronic skin ulcers independently from the multidrug resistant phenotype. Int J Mol Sci. 2017;18:1077. https://doi.org/10.3390/ijms18051077.

29.Johnson TR, Gomez BI, McIntyre MK, Dubick MA, Christy RJ, Nicholson SE, et al. The cutaneous microbiome and wounds: new molecular targets to promote wound healing. Int J Mol Sci. 2018;19:2699. https://doi.org/10.3390/ijms19092699.

30.Versey Z, da Cruz Nizer WS, Russell E, Zigic S, DeZeeuw KG, Marek JE, et al. Biofilm-innate immune Interface: contribution to chronic wound formation. Front Immunol. 2021;12:648554. https://doi.org/10.3389/fimmu.2021.648554.

31.Wu YK, Cheng NC, Cheng CM. Biofilms in chronic wounds: pathogenesis and diagnosis. Trends Biotechnol. 2019;37:505–17.

32.Xuan Q, Jiang F, Dong H, Zhang W, Zhang F, Ma T, et al. Bioinspired intrinsic versatile hydrogel fabricated by amyloidal toxin simulant-based Nanofibrous assemblies for accelerated diabetic wound healing. Adv Funct Mater. 2021;31:2106705. https://doi.org/10.1002/adfm.202106705.

33.Liu YF, Ni PW, Huang Y, Xie T. Therapeutic strategies for chronic wound infection. Chin J Traumatol. 2021;25:11–6.

34.Bertesteanu S, Triaridis S, Stankovic M, Lazar V, Chifiriuc MC, Vlad M, et al. Polymicrobial wound infections: pathophysiology and current therapeutic approaches. Int J Pharm. 2014;463:119–26.

35.Uçkay I, Gariani K, Pataky Z, Lipsky BA. Diabetic foot infections: state-of-the-art. Diabetes Obes Metab. 2014;16:305–16.

36.Kalan LR, Brennan MB. The role of the microbiome in nonhealing diabetic wounds. Ann N Y Acad Sci. 2019;1435:79–92.

37.Wei S, Xu P, Yao Z, Cui X, Lei X, Li L, et al. A composite hydrogel with co-delivery of antimicrobial peptides and platelet-rich plasma to enhance healing of infected wounds in diabetes. Acta Biomater. 2021;124:205–18.

38.Trivedi U, Madsen JS, Rumbaugh KP, Wolcott RD, Burmolle M, Sorensen SJ. A post-planktonic era of in vitro infectious models: issues and changes addressed by a clinically relevant wound like media. Crit Rev Microbiol. 2017;43:453–65.

39.Zhou J, Yao D, Qian Z, Hou S, Li L, Jenkins ATA, et al. Bacteria-responsive intelligent wound dressing: simultaneous in situ detection and inhibition of bacterial infection for accelerated wound healing. Biomaterials. 2018;161:11–23.

40.Norman G, Dumville JC, Moore ZE, Tanner J, Christie J, Goto S. Antibiotics and antiseptics for pressure ulcers. Cochrane Database Syst Rev. 2016;4:CD011586. https://doi.org/10.1002/14651858.CD011586.pub2.

41.O'Meara S, Al-Kurdi D, Ologun Y, Ovington LG, Martyn-St James M, Richardson R. Antibiotics and antiseptics for venous leg ulcers. Cochrane Database Syst Rev. 2014;1:CD003557. https://doi.org/10.1002/14651858.CD003557.pub5.

42.Pugliese DJ. Infection in venous leg ulcers: considerations for optimal Management in the Elderly. Drugs Aging. 2016;33:87–96.

43.Leaper D, Assadian O, Edmiston CE. Approach to chronic wound infections. Br J Dermatol. 2015;173:351–8.

44.Thet NT, Mercer-Chalmers J, Greenwood RJ, Young AER, Coy K, Booth S, et al. SPaCE swab: point-of-care sensor for simple and rapid detection of acute wound infection. ACS Sens. 2020;5:2652–7.

45.Reddy M, Gill SS, Wu W, Kalkar SR, Rochon PA. Does this patient have an infection of a chronic wound? JAMA. 2012;307:605–11.

46.Bystritsky R, Chambers H. Cellulitis and soft tissue infections. Ann Intern Med. 2018;168:ITC17–32.

47.Jnana A, Muthuraman V, Varghese VK, Chakrabarty S, Murali TS, Ramachandra L, et al. Microbial community distribution and Core microbiome in successive wound grades of individuals with diabetic foot ulcers. Appl Environ Microbiol. 2020;86. https://doi.org/10.1128/AEM.02608-19.

48.Liu C, Ponsero AJ, Armstrong DG, Lipsky BA, Hurwitz BL. The dynamic wound microbiome. BMC Med. 2020;18:358. https://doi.org/10.1186/s12916-020-01820-6.

49.Wolcott R, Costerton JW, Raoult D, Cutler SJ. The polymicrobial nature of biofilm infection. Clin Microbiol Infect. 2013;19:107–12.

50.Chin JS, Madden L, Chew SY, Becker DL. Drug therapies and delivery mechanisms to treat perturbed skin wound healing. Adv Drug Deliv Rev. 2019;149-150:2–18.

51.Daeschlein G. Antimicrobial and antiseptic strategies in wound management. Int Wound J. 2013;10:9–14.

52.Szweda P, Gorczyca G, Tylingo R. Comparison of antimicrobial activity of selected, commercially available wound dressing materials. J Wound Care. 2018;27:320–6.

53.Schwarzer S, James GA, Goeres D, Bjarnsholt T, Vickery K, Percival SL, et al. The efficacy of topical agents used in wounds for managing chronic biofilm infections: a systematic review. J Inf Secur. 2020;80:261–70.

54.Chen Z, Wang Z, Ren J, Qu X. Enzyme mimicry for combating bacteria and biofilms. Acc Chem Res. 2018;51:789–99.

55.Eardley WG, Brown KV, Bonner TJ, Green AD, Clasper JC. Infection in conflict wounded. Philos Trans R Soc Lond Ser B Biol Sci. 2011;366:204–18.

56.Gardner SE, Haleem A, Jao YL, Hillis SL, Femino JE, Phisitkul P, et al. Cultures of diabetic foot ulcers without clinical signs of infection do not predict outcomes. Diabetes Care. 2014;37:2693–701.

57.Falcone M, De Angelis B, Pea F, Scalise A, Stefani S, Tasinato R, et al. Challenges in the management of chronic wound infections. J Glob Antimicrob Resist. 2021;26:140–7.

58.Verbanic S, Shen Y, Lee J, Deacon JM, Chen IA. Microbial predictors of healing and short-term effect of debridement on the microbiome of chronic wounds. NPJ Biofilms Microbiomes. 2020;6:21. https://doi.org/10.1038/s41522-020-0130-5.

59.Tisi PV, Than MM, Cochrane Vascular Group. Type of incision for below knee amputation. Cochrane Database Syst Rev. 2014;4:CD003749. https://doi.org/10.1002/14651858.CD003749.pub3.

60.Blazar PE, Garon MT. Ray resections of the fingers: indications, techniques, and outcomes. J Am Acad Orthop Surg. 2015;23:476–84.

61.Chang M, Nguyen TT. Strategy for treatment of infected diabetic foot ulcers. Acc Chem Res. 2021;54:1080–93.

62.Grada A, Mervis J, Falanga V. Research techniques made simple: animal models of wound healing. J Invest Dermatol. 2018;138:2095–2105.e1. https://doi.org/10.1016/j.jid.2019.03.1134.

63.Kathawala MH, Ng WL, Liu D, Naing MW, Yeong WY, Spiller KL, et al. Healing of chronic wounds: An update of recent developments and future possibilities. Tissue Eng Part B Rev. 2019;25:429–44.

64.Sanapalli BKR, Yele V, Singh MK, Thaggikuppe Krishnamurthy P, Karri V. Preclinical models of diabetic wound healing: a critical review. Biomed Pharmacother. 2021;142:111946. https://doi.org/10.1016/j.biopha.2021.111946.

65.Zindle JK, Wolinsky E, Bogie KM. A review of animal models from 2015 to 2020 for preclinical chronic wounds relevant to human health. J Tissue Viability. 2021;30:291–300.

66.Suo H, Hussain M, Wang H, Zhou N, Tao J, Jiang H, et al. Correction to “injectable and pH-sensitive hyaluronic acid-based hydrogels with on-demand release of antimicrobial peptides for infected wound healing”. Biomacromolecules. 2021;22:5400. https://doi.org/10.1021/acs.biomac.1c01487.

67.Thapa RK, Diep DB, Tonnesen HH. Topical antimicrobial peptide formulations for wound healing: current developments and future prospects. Acta Biomater. 2020;103:52–67.

68.Mofazzal Jahromi MA, Sahandi Zangabad P, Moosavi Basri SM, Sahandi Zangabad K, Ghamarypour A, Aref AR, et al. Nanomedicine and advanced technologies for burns: preventing infection and facilitating wound healing. Adv Drug Deliv Rev. 2018;123:33–64.

69.Kwakman PH, Krijgsveld J, de Boer L, Nguyen LT, Boszhard L, Vreede J, et al. Native thrombocidin-1 and unfolded thrombocidin-1 exert antimicrobial activity via distinct structural elements. J Biol Chem. 2011;286:43506–14.

70.Riool M, de Breij A, Kwakman PHS, Schonkeren-Ravensbergen E, de Boer L, Cordfunke RA, et al. Thrombocidin-1-derived antimicrobial peptide TC19 combats superficial multi-drug resistant bacterial wound infections. Biochim Biophys Acta Biomembr. 2020;1862:183282. https://doi.org/10.1016/j.bbamem.2020.183282.

71.Diaz E, Fernandez IM, Jimenez L, Rodriguez M, Surani S. Is methicillin-resistant Staphylococcus aureus pneumonia epidemiology and sensitivity changing? Am J Med Sci. 2012;343:196–8.

72.Hakansson J, Cavanagh JP, Stensen W, Mortensen B, Svendsen JS, Svenson J. In vitro and in vivo antibacterial properties of peptide AMC-109 impregnated wound dressings and gels. J Antibiot (Tokyo). 2021;74:337–45.

73.Gorr SU, Flory CM, Schumacher RJ. In vivo activity and low toxicity of the second-generation antimicrobial peptide DGL13K. PLoS One. 2019;14:e0216669. https://doi.org/10.1371/journal.pone.0216669.

74.Gan BH, Gaynord J, Rowe SM, Deingruber T, Spring DR. The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions. Chem Soc Rev. 2021;50:7820–80.

75.Li W, Separovic F, O'Brien-Simpson NM, Wade JD. Chemically modified and conjugated antimicrobial peptides against superbugs. Chem Soc Rev. 2021;50:4932–73.

76.Ong ZY, Wiradharma N, Yang YY. Strategies employed in the design and optimization of synthetic antimicrobial peptide amphiphiles with enhanced therapeutic potentials. Adv Drug Deliv Rev. 2014;78:28–45.

77.Liu S, Fukushima K, Venkataraman S, Hedrick JL, Yang YY. Supramolecular nanofibers self-assembled from cationic small molecules derived from repurposed poly(ethylene teraphthalate) for antibiotic delivery. Nanomedicine. 2018;14:165–72.

78.Fumakia M, Ho EA. Nanoparticles encapsulated with LL37 and serpin A1 promotes wound healing and synergistically enhances antibacterial activity. Mol Pharm. 2016;13:2318–31.

79.Comune M, Rai A, Chereddy KK, Pinto S, Aday S, Ferreira AF, et al. Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential. J Control Release. 2017;262:58–71.

80.Chen WY, Chang HY, Lu JK, Huang YC, Harroun SG, Tseng YT, et al. Self-assembly of antimicrobial peptides on gold Nanodots: against multidrug-resistant bacteria and wound-healing application. Adv Funct Mater. 2016;25:7189–99.

81.Gao L, Giglio KM, Nelson JL, Sondermann H, Travis AJ. Ferromagnetic nanoparticles with peroxidase-like activity enhance the cleavage of biological macromolecules for biofilm elimination. Nanoscale. 2014;6:2588–93.

82.Baistrocchi SR, Lee MJ, Lehoux M, Ralph B, Snarr BD, Robitaille R, et al. Posaconazole-loaded leukocytes as a novel treatment strategy targeting invasive pulmonary aspergillosis. J Infect Dis. 2017;215:1734–41.

83.Matsuzaki S, Yasuda M, Nishikawa H, Kuroda M, Ujihara T, Shuin T, et al. Experimental protection of mice against lethal Staphylococcus aureus infection by novel bacteriophage phi MR11. J Infect Dis. 2003;187:613–24.

84.Wittebole X, De Roock S, Opal SM. A historical overview of bacteriophage therapy as an alternative to antibiotics for the treatment of bacterial pathogens. Virulence. 2014;5:226–35.

85.Bull JJ, Gill JJ. The habits of highly effective phages: population dynamics as a framework for identifying therapeutic phages. Front Microbiol. 2014;5:618. https://doi.org/10.3389/fmicb.2014.00618.

86.Pinto AM, Cerqueira MA, Banobre-Lopes M, Pastrana LM, Sillankorva S. Bacteriophages for chronic wound treatment: from traditional to novel delivery systems. Viruses. 2020;12:235. https://doi.org/10.3390/v12020235.

87.Kering KK, Kibii BJ, Wei H. Biocontrol of phytobacteria with bacteriophage cocktails. Pest Manag Sci. 2019;75:1775–81.

88.Rhoads DD, Wolcott RD, Kuskowski MA, Wolcott BM, Ward LS, Sulakvelidze A. Bacteriophage therapy of venous leg ulcers in humans: results of a phase I safety trial. J Wound Care. 2013;18:237–8 240-3.

89.Fish R, Kutter E, Wheat G, Blasdel B, Kutateladze M, Kuhl S. Compassionate use of bacteriophage therapy for foot ulcer treatment as an effective step for moving toward clinical trials. Methods Mol Biol. 2018;1693:159–70.

90.Fish R, Kutter E, Wheat G, Blasdel B, Kutateladze M, Kuhl S. Bacteriophage treatment of intransigent diabetic toe ulcers: a case series. J Wound Care. 2016;25:S27–33.

91.Huh H, Wong S, St. Jean J, Slavcev R. Bacteriophage interactions with mammalian tissue: therapeutic applications. Adv Drug Deliv Rev. 2019;145:4–17.

92.Kharaziha M, Baidya A, Annabi N. Rational Design of Immunomodulatory Hydrogels for chronic wound healing. Adv Mater. 2021;33:2100176. https://doi.org/10.1002/adma.202100176.

93.Fathi A, Mithieux SM, Wei H, Chrzanowski W, Valtchev P, Weiss AS, et al. Elastin based cell-laden injectable hydrogels with tunable gelation, mechanical and biodegradation properties. Biomaterials. 2014;35:5425–35.

94.Zheng Z, Bian S, Li Z, Zhang Z, Liu Y, Zhai X, et al. Catechol modified quaternized chitosan enhanced wet adhesive and antibacterial properties of injectable thermo-sensitive hydrogel for wound healing. Carbohydr Polym. 2020;249:116826. https://doi.org/10.1016/j.carbpol.2020.116826.

95.Yun EJ, Yon B, Joo MK, Jeong B. Cell therapy for skin wound using fibroblast encapsulated poly(ethylene glycol)-poly(L-alanine) thermogel. Biomacromolecules. 2012;13:1106–11.

96.Dang Q, Liu K, Zhang Z, Liu C, Liu X, Xin Y, et al. Fabrication and evaluation of thermosensitive chitosan/collagen/α, β-glycerophosphate hydrogels for tissue regeneration. Carbohydr Polym. 2017;167:145–57.

97.Aliakbar Ahovan Z, Khosravimelal S, Eftekhari BS, Mehrabi S, Hashemi A, Eftekhari S, et al. Thermo-responsive chitosan hydrogel for healing of full-thickness wounds infected with XDR bacteria isolated from burn patients: in vitro and in vivo animal model. Int J Biol Macromol. 2020;164:4475–86.

98.Schaude C, Fröhlich E, Meindl C, Attard J, Binder B, Mohr GJ. The development of indicator cotton swabs for the detection of pH in wounds. Sensors (Basel). 2017;17:1365. https://doi.org/10.3390/s17061365.

99.Ono S, Imai R, Ida Y, Shibata D, Komiya T, Matsumura H. Increased wound pH as an indicator of local wound infection in second degree burns. Burns. 2015;41:820–4.

100.Zepon KM, Martins MM, Marques MS, Heckler JM, Dal Pont Morisso F, Moreira MG, et al. Smart wound dressing based on κ–carrageenan/locust bean gum/cranberry extract for monitoring bacterial infections. Carbohydr Polym. 2019;206:362–70.

101.Arafa AA, Nada AA, Ibrahim AY, Sajkiewicz P, Zahran MK, Hakeim OA. Preparation and characterization of smart therapeutic pH-sensitive wound dressing from red cabbage extract and chitosan hydrogel. Int J Biol Macromol. 2021;182:1820–31.

102.Reshmi CR, Suja PS, Manaf O, Sanu PP, Sujith A. Nanochitosan enriched poly epsilon-caprolactone electrospun wound dressing membranes: a fine tuning of physicochemical properties, hemocompatibility and curcumin release profile. Int J Biol Macromol. 2018;108:1261–72.

103.Ren Y, Yu X, Li Z, Liu D, Xue X. Fabrication of pH-responsive TA-keratin bio-composited hydrogels encapsulated with photoluminescent GO quantum dots for improved bacterial inhibition and healing efficacy in wound care management: in vivo wound evaluations. J Photochem Photobiol B. 2020;202:111676. https://doi.org/10.1016/j.jphotobiol.2019.111676.

104.Liu X, Cao J, Li H, Li J, Jin Q, Ren K, et al. Mussel-inspired polydopamine: a biocompatible and ultrastable coating for nanoparticles in vivo. ACS Nano. 2013;7:9384–95.

105.Liu Y, Ai K, Liu J, Deng M, He Y, Lu L. Dopamine-melanin colloidal nanospheres: an efficient near-infrared photothermal therapeutic agent for in vivo cancer therapy. Adv Mater. 2013;25:1353–9.

106.Gao G, Jiang YW, Jia HR, Wu FG. Near-infrared light-controllable on-demand antibiotics release using thermo-sensitive hydrogel-based drug reservoir for combating bacterial infection. Biomaterials. 2019;188:83–95.

107.Zheng BD, Ye J, Yang YC, Huang YY, Xiao MT. Self-healing polysaccharide-based injectable hydrogels with antibacterial activity for wound healing. Carbohydr Polym. 2022;275:118770. https://doi.org/10.1016/j.carbpol.2021.118770.

108.Yang X, Li P, Tang W, Du S, Yu M, Lu H, et al. A facile injectable carbon dot/oxidative polysaccharide hydrogel with potent self-healing and high antibacterial activity. Carbohydr Polym. 2021;251:117040. https://doi.org/10.1016/j.carbpol.2020.117040.

109.Cross ER, Coulter SM, Pentlavalli S, Laverty G. Unravelling the antimicrobial activity of peptide hydrogel systems: current and future perspectives. Soft Matter. 2021;17:81–821.

110.Lopez-Silva TL, Leach DG, Azares A, Li IC, Woodside DG, Hartgerink JD. Chemical functionality of multidomain peptide hydrogels governs early host immune response. Biomaterials. 2020;231:119667. https://doi.org/10.1016/j.biomaterials.2019.119667.

111.Carrejo NC, Moore AN, Lopez Silva TL, Leach DG, Li IC, Walker DR, et al. Multidomain peptide hydrogel accelerates healing of full-thickness wounds in diabetic mice. ACS Biomater Sci Eng. 2018;4:1386–96.

112.He Y, Zhao W, Dong Z, Ji Y, Li M, Hao Y, et al. A biodegradable antibacterial alginate/carboxymethyl chitosan/Kangfuxin sponges for promoting blood coagulation and full-thickness wound healing. Int J Biol Macromol. 2021;167:182–92.

113.Roberts AE, Maddocks SE, Cooper RA. Manuka honey reduces the motility of Pseudomonas aeruginosa by suppression of flagella-associated genes. J Antimicrob Chemother. 2015;70:716–25.

114.Xia T, Xie F, Bian X, Chen Z, Zhang S, Fang Z, et al. Ultrabroad-spectrum, multidrug resistant bacteria-killing, and biocompatible quaternized chitin derivative for infected wound healing. Mater Sci Eng C Mater Biol Appl. 2021;126:112177. https://doi.org/10.1016/j.msec.2021.112177.

115.Widsten P, Cruz CD, Fletcher GC, Pajak MA, McGhie TK. Tannins and extracts of fruit byproducts: antibacterial activity against foodborne bacteria and antioxidant capacity. J Agric Food Chem. 2014;62:11146–56.

116.Su X, Liu X, Wang S, Li B, Pan T, Liu D, et al. Wound-healing promoting effect of total tannins from Entada phaseoloides (L.) Merr. In rats. Burns. 2017;43:830–8.

117.Xu F, Weng B, Gilkerson R, Materon LA, Lozano K. Development of tannic acid/chitosan/pullulan composite nanofibers from aqueous solution for potential applications as wound dressing. Carbohydr Polym. 2015;115:16–24.

118.Low WL, Kenward K, Britland ST, Amin MC, Martin C. Essential oils and metal ions as alternative antimicrobial agents: a focus on tea tree oil and silver. Int Wound J. 2017;14:369–84.

119.Perez-Recalde M, Ruiz Arias IE, Hermida EB. Could essential oils enhance biopolymers performance for wound healing? A systematic review. Phytomedicine. 2018;38:57–65.

120.Singh S, Gupta A, Sharma D, Gupta B. Dextran based herbal nanobiocomposite membranes for scar free wound healing. Int J Biol Macromol. 2018;113:227–39.

121.Pierpaoli E, Orlando F, Cirioni O, Simonetti O, Giacometti A, Provinciali M. Supplementation with tocotrienols from Bixa orellana improves the in vivo efficacy of daptomycin against methicillin-resistant Staphylococcus aureus in a mouse model of infected wound. Phytomedicine. 2017;36:50–3.

122.Mehwish HM, Liu G, Rajoka MSR, Cai H, Zhong J, Song X, et al. Therapeutic potential of Moringa oleifera seed polysaccharide embedded silver nanoparticles in wound healing. Int J Biol Macromol. 2021;184:144–58.

123.Marinas IC, Oprea E, Geana EI, Tutunaru O, Pircalabioru GG, Zgura I, et al. Valorization of Gleditsia triacanthos invasive plant cellulose microfibers and phenolic compounds for obtaining multi-functional wound dressings with antimicrobial and antioxidant properties. Int J Mol Sci. 2020;22. https://doi.org/10.3390/ijms22010033.

124.Ma M, Zhong Y, Jiang X. Thermosensitive and pH-responsive tannin-containing hydroxypropyl chitin hydrogel with long-lasting antibacterial activity for wound healing. Carbohydr Polym. 2020;236:116096. https://doi.org/10.1016/j.carbpol.2020.116096.

125.Gharib A, Faezizadeh Z, Godarzee M. Therapeutic efficacy of epigallocatechin gallate-loaded nanoliposomes against burn wound infection by methicillin-resistant Staphylococcus aureus. Skin Pharmacol Physiol. 2013;26:68–75.

126.Barbosa R, Villarreal A, Rodriguez C, De Leon H, Gilkerson R, Lozano K. Aloe Vera extract-based composite nanofibers for wound dressing applications. Mater Sci Eng C Mater Biol Appl. 2021;124:112061. https://doi.org/10.1016/j.msec.2021.112061.

127.Anjum S, Gupta A, Sharma D, Gautam D, Bhan S, Sharma A, et al. Development of novel wound care systems based on nanosilver nanohydrogels of polymethacrylic acid with Aloe vera and curcumin. Mater Sci Eng C Mater Biol Appl. 2016;64:157–66.

128.Gupta B, Agarwal R, Sarwar Alam M. Antimicrobial and release study of drug loaded PVA/PEO/CMC wound dressings. J Mater Sci Mater Med. 2014;25:1613–22.

129.Karumathil DP, Surendran-Nair M, Venkitanarayanan K. Efficacy of trans-cinnamaldehyde and eugenol in reducing Acinetobacter baumannii adhesion to and invasion of human keratinocytes and controlling wound infection in vitro. Phytother Res. 2016;30:2053–9.

130.Yin C, Xie L, Guo Y. Phytochemical analysis and antibacterial activity of Gentiana macrophylla extract against bacteria isolated from burn wound infections. Microb Pathog. 2018;114:25–8.

131.Sarhan WA, Azzazy HM, El-Sherbiny IM. Honey/chitosan nanofiber wound dressing enriched with Allium sativum and cleome droserifolia: enhanced antimicrobial and wound healing activity. ACS Appl Mater Interfaces. 2016;8:6379–90.

132.Zhou L, Cai L, Ruan H, Zhang L, Wang J, Jiang H, et al. Electrospun chitosan oligosaccharide/polycaprolactone nanofibers loaded with wound-healing compounds of Rutin and quercetin as antibacterial dressings. Int J Biol Macromol. 2021;183:1145–54.

133.Kim BE, Goleva E, Hall CF, Park SH, Lee UH, Brauweiler AM, et al. Skin wound healing is accelerated by a lipid mixture representing major lipid components of Chamaecyparis obtusa plant extract. J Invest Dermatol. 2018;138:1176–86.

134.Farahpour MR, Pirkhezr E, Ashrafian A, Sonboli A. Accelerated healing by topical administration of Salvia officinalis essential oil on Pseudomonas aeruginosa and Staphylococcus aureus infected wound model. Biomed Pharmacother. 2020;128:110120. https://doi.org/10.1016/j.biopha.2020.110120.

135.Farahpour MR, Sheikh S, Kafshdooz E, Sonboli A. Accelerative effect of topical Zataria multiflora essential oil against infected wound model by modulating inflammation, angiogenesis, and collagen biosynthesis. Pharm Biol. 2021;59:1–10.

136.Khezri K, Farahpour MR, Mounesi Rad S. Accelerated infected wound healing by topical application of encapsulated rosemary essential oil into nanostructured lipid carriers. Artif Cells Nanomed Biotechnol. 2019;47:980–8.

137.Saporito F, Sandri G, Bonferoni MC, Rossi S, Boselli C, Icaro Cornaglia A, et al. Essential oil-loaded lipid nanoparticles for wound healing. Int J Nanomedicine. 2018;13:175–86.

138.Melendez JH, Frankel YM, An AT, Williams L, Price LB, Wang NY, et al. Real-time PCR assays compared to culture-based approaches for identification of aerobic bacteria in chronic wounds. Clin Microbiol Infect. 2010;16:1762–9.

139.Rennie MY, Dunham D, Lindvere-Teene L, Raizman R, Hill R, Linden R. Understanding real-time fluorescence signals from bacteria and wound tissues observed with the MolecuLight i:X(TM). Diagnostics (Basel). 2019;9. https://doi.org/10.3390/diagnostics9010022.

140.Vyas KS, Wong LK. Detection of biofilm in wounds as an early indicator for risk for tissue infection and wound chronicity. Ann Plast Surg. 2016;76:127–31.

141.Wei D, Zhu X-M, Chen Y-Y, Li X-Y, Chen Y-P, Liu H-Y, et al. Chronic wound biofilms: diagnosis and therapeutic strategies. Chin Med J. 2019;132:2737–44.

142.Watters C, Everett JA, Haley C, Clinton A, Rumbaugh KP. Insulin treatment modulates the host immune system to enhance Pseudomonas aeruginosa wound biofilms. Infect Immun. 2014;82:92–100.

143.Valente PMDS, Deva A, Ngo Q, Vickery K. The increased killing of biofilms in vitro by combining topical silver dressings with topical negative pressure in chronic wounds. Int Wound J. 2016;13:130–6.

144.Khalil MA, El Maghraby GM, Sonbol FI, Allam NG, Ateya PS, Ali SS. Enhanced efficacy of some antibiotics in presence of silver nanoparticles against multidrug resistant Pseudomonas aeruginosa recovered from burn wound infections. Front Microbiol. 2021;12:648560. https://doi.org/10.3389/fmicb.2021.648560.

145.Tewarie L, Chernigov N, Goetzenich A, Moza A, Autschbach R, Zayat R. The effect of ultrasound-assisted debridement combined with vacuum pump therapy in deep sternal wound infections. Ann Thorac Cardiovasc Surg. 2018;24:139–46.

146.Satish L, Gallo PH, Johnson S, Yates CC, Kathju S. Local probiotic therapy with lactobacillus plantarum mitigates scar formation in rabbits after burn injury and infection. Surg Infect. 2017;18:119–27.

147.Valdez JC, Peral MC, Rachid M, Santana M, Perdigon G. Interference of lactobacillus plantarum with Pseudomonas aeruginosa in vitro and in infected burns: the potential use of probiotics in wound treatment. Clin Microbiol Infect. 2005;11:472–9.

148.Lu Y, Li H, Wang J, Yao M, Peng Y, Liu T, et al. Engineering bacteria-activated multifunctionalized hydrogel for promoting diabetic wound healing. Adv Funct Mater. 2021;31:2105749. https://doi.org/10.1002/adfm.202105749.

149.Wang G, Sweren E, Liu H, Wier E, Alphonse MP, Chen R, et al. Bacteria induce skin regeneration via IL-1β signaling. Cell Host Microbe. 2021;29:777–91.e6.

150.Kalan LR, Meisel JS, Loesche MA, Horwinski J, Soaita I, Chen X, et al. Strain- and species-level variation in the microbiome of diabetic wounds is associated with clinical outcomes and therapeutic efficacy. Cell Host Microbe. 2019;25:641–55.e5.

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