Effects of fish oil-containing nutrition supplementation in adult sepsis patients: a systematic review and meta-analysis

Hongyu Wang; Sen Su; Chao Wang; Jianhong Hu; Wu Dan; Xi Peng

doi:10.1093/burnst/tkac012

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Effects of fish oil-containing nutrition supplementation in adult sepsis patients: a systematic review and meta-analysis

更新时间：2023-09-05

- Effects of fish oil-containing nutrition supplementation in adult sepsis patients: a systematic review and meta-analysis
- Effects of fish oil-containing nutrition supplementation in adult sepsis patients: a systematic review and meta-analysis
- Burns & Trauma 2022年10卷第1期
- 作者机构：
  
  1. Clinical Medical Research Center, Southwest Hospital, The Third Military Medical University
  2. Department of Burns and Plastic, PLA No. Hospital,983
  3. Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, The Third Military Medical University
- 作者简介：
- 基金信息：
  
  This work was supported by the National Natural Science Foundation of China (No. 81971838) and the Clinical Research Foundation of TMMU (No. 2018XLC2006).
- DOI：10.1093/burnst/tkac012
  中图分类号：
- 纸质出版日期：2022，
  
  网络出版日期：2022-6-10，
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Effects of fish oil-containing nutrition supplementation in adult sepsis patients: a systematic review and meta-analysis[J]. Burns & Trauma, 2022,10(1).

Hongyu Wang, Sen Su, Chao Wang, Jianhong Hu, Wu Dan, Xi Peng, Effects of fish oil-containing nutrition supplementation in adult sepsis patients: a systematic review and meta-analysis, Burns & Trauma, Volume 10, 2022, tkac012, https://doi.org/10.1093/burnst/tkac012
Effects of fish oil-containing nutrition supplementation in adult sepsis patients: a systematic review and meta-analysis[J]. Burns & Trauma, 2022,10(1). DOI： 10.1093/burnst/tkac012.

Hongyu Wang, Sen Su, Chao Wang, Jianhong Hu, Wu Dan, Xi Peng, Effects of fish oil-containing nutrition supplementation in adult sepsis patients: a systematic review and meta-analysis, Burns & Trauma, Volume 10, 2022, tkac012, https://doi.org/10.1093/burnst/tkac012 DOI：

摘要

Abstract

BackgroundSepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Although fish oil has been used as an immunonutritional preparations for the treatment of sepsis patients

there is still controversy as to whether it is beneficial to them. We systematically reviewed published clinical trial data to evaluate the effectiveness of fish oil-containing nutrition supplementation in sepsis patients.MethodsA systematic search was undertaken in PubMed

Embase

Chinese Biomedicine Database

the Cochrane Library and the China Knowledge Resource Integrated Database to obtain clinical controlled trails. RCTs on nutrition therapy containing fish oil among adult sepsis patients were selected for analysis in comparison with routine therapy.ResultsTwenty-five published trials were included in the meta-analysis. Fish oil-containing nutrition supplementation reduced the mortality compared with the control group (relative risk (RR) 0.74

I2 = 0%). Fish oil also shortened the ICU stay (MD −3.57 days; 95% CI −4.54

−2.59; p<0.00001; I2 = 76%)

hospital stay (MD −9.92 days; 95% CI −15.37

−4.46; p = 0.0004; I2 = 91%) and the duration of mechanical ventilation support (MD −2.26; 95% CI −4.27

−0.26; p = 0.03; I2 = 83%). A subgroup analysis based on the route of administration revealed that parenteral administration of fish oil could reduce mortality in septic patients (RR =0.68

I2 = 0%)

but no significant difference in mortality was observed in the fish oil group administered by enteral route (RR = 0.80

I2 = 0%). No statistically significant publication biases were detected for the above clinical endpoints (p>0.05).ConclusionsParenteral nutrition containing fish oil could significantly decrease mortality in sepsis patients while enteral administration could not. Fish oil-containing nutrition supplementation.

关键词

Keywords

SepsisFish oilMeta-analysisNutrition therapyOmega-3 fatty acids

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