Applications of tetrahedral DNA nanostructures in wound repair and tissue regeneration

Yikai Dou; Weitong Cui; Xiao Yang; Yunfeng Lin; Xiaohong Ma; Xiaoxiao Cai

doi:10.1093/burnst/tkac006

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Applications of tetrahedral DNA nanostructures in wound repair and tissue regeneration

更新时间：2022-06-09

- Applications of tetrahedral DNA nanostructures in wound repair and tissue regeneration
- Applications of tetrahedral DNA nanostructures in wound repair and tissue regeneration
- Burns & Trauma 2022年10卷第1期
- 作者机构：
  
  1. Psychiatric Laboratory and Mental Health Center
  2. West China Hospital of Sichuan University
  3. State Key Laboratory of Oral Diseases
  4. Sichuan University
- 作者简介：
- 基金信息：
  
  This research was supported by the National Key R&D Program of China (No. 2019YFA0110600), National Natural Science Foundation of China (Nos. 82001432, 81970916), China Postdoctoral Science Foundation (Nos. 2020TQ0213, 2020 M683319) and West China Hospital Postdoctoral Science Foundation (No. 2020HXBH104).
- DOI：10.1093/burnst/tkac006
  中图分类号：
- 纸质出版日期：2022，
  
  网络出版日期：2022-3-10，
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Applications of tetrahedral DNA nanostructures in wound repair and tissue regeneration[J]. Burns & Trauma, 2022,10(1).

Yikai Dou, Weitong Cui, Xiao Yang, Yunfeng Lin, Xiaohong Ma, Xiaoxiao Cai, Applications of tetrahedral DNA nanostructures in wound repair and tissue regeneration, Burns & Trauma, Volume 10, 2022, tkac006, https://doi.org/10.1093/burnst/tkac006
Applications of tetrahedral DNA nanostructures in wound repair and tissue regeneration[J]. Burns & Trauma, 2022,10(1). DOI： 10.1093/burnst/tkac006.

Yikai Dou, Weitong Cui, Xiao Yang, Yunfeng Lin, Xiaohong Ma, Xiaoxiao Cai, Applications of tetrahedral DNA nanostructures in wound repair and tissue regeneration, Burns & Trauma, Volume 10, 2022, tkac006, https://doi.org/10.1093/burnst/tkac006 DOI：

摘要

Abstract

Tetrahedral DNA nanostructures (TDNs) are molecules with a pyramidal structure formed by folding four single strands of DNA based on the principle of base pairing. Although DNA has polyanionic properties

the special spatial structure of TDNs allows them to penetrate the cell membrane without the aid of transfection agents in a caveolin-dependent manner and enables them to participate in the regulation of cellular processes without obvious toxic side effects. Because of their stable spatial structure

TDNs resist the limitations imposed by nuclease activity and innate immune responses to DNA. In addition

TDNs have good editability and biocompatibility

giving them great advantages for biomedical applications. Previous studies have found that TDNs have a variety of biological properties

including promoting cell migration

proliferation and differentiation

as well as having anti-inflammatory

antioxidant

anti-infective and immune regulation capabilities. Moreover

we confirmed that TDNs can promote the regeneration and repair of skin

blood vessels

muscles and bone tissues. Based on these findings

we believe that TDNs have broad prospects for application in wound repair and regeneration. This article reviews recent progress in TDN research and its applications.

关键词

Keywords

Tetrahedral DNA nanostructuresWound treatmentInjury repairInjury regenerationTissue regeneration

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