Autophagy and skin wound healing

Haiyue Ren; Feng Zhao; Qiqi Zhang; Xing Huang; Zhe Wang

doi:10.1093/burnst/tkac003

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Autophagy and skin wound healing

更新时间：2022-06-09

- Autophagy and skin wound healing
- Autophagy and skin wound healing
- Burns & Trauma 2022年10卷第1期
- 作者机构：
  
  1. Department of Pathology
  2. Shengjing Hospital of China Medical University
  3. Department of Stem Cells and Regenerative Medicine
  4. China Medical University
  5. Department of General Surgery
- 作者简介：
- 基金信息：
  
  This work was supported by the National Natural Science Foundation of China (Nos. 81601692, 81901969), the Technology Research from the Department of Education of Liaoning Province (No. JCZR2020013), 345 Talent Project of Shenjing hospital of China Medical University.
- DOI：10.1093/burnst/tkac003
  中图分类号：
- 纸质出版日期：2022，
  
  网络出版日期：2022-2-16，
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Autophagy and skin wound healing[J]. Burns & Trauma, 2022,10(1).

Haiyue Ren, Feng Zhao, Qiqi Zhang, Xing Huang, Zhe Wang, Autophagy and skin wound healing, Burns & Trauma, Volume 10, 2022, tkac003, https://doi.org/10.1093/burnst/tkac003
Autophagy and skin wound healing[J]. Burns & Trauma, 2022,10(1). DOI： 10.1093/burnst/tkac003.

Haiyue Ren, Feng Zhao, Qiqi Zhang, Xing Huang, Zhe Wang, Autophagy and skin wound healing, Burns & Trauma, Volume 10, 2022, tkac003, https://doi.org/10.1093/burnst/tkac003 DOI：

摘要

Abstract

Autophagy is a lysosome-dependent

self-renewal mechanism that can degrade and recycle cellular components in eukaryotic cells to maintain the stability of the intracellular environment and the cells ability to cope with unfavorable environments. Numerous studies suggest that autophagy participates in regulating various cellular functions and is closely associated with the onset and progression of various diseases. Wound healing is a complex

multistep biological process that involves multiple cell types. Refractory wounds

which include diabetic skin ulcers

can seriously endanger human health. Previous studies have confirmed that autophagy plays an essential role in various phases of wound healing. Specifically

in the inflammatory phase

autophagy has an anti-infection effect and it negatively regulates the inflammatory response

which prevents excessive inflammation from causing tissue damage. In the proliferative phase

local hypoxia in the wound can induce autophagy

which plays a role in anti-apoptosis and anti-oxidative stress and promotes cell survival. Autophagy of vascular endothelial cells promotes wound angiogenesis and that of keratinocytes promotes their differentiation

proliferation and migration

which is conducive to the completion of wound re-epithelialisation. In the remodeling phase

autophagy of fibroblasts affects the formation of hypertrophic scars. Additionally

a refractory diabetic wound may be associated with increased levels of autophagy

and the regulation of mesenchymal stem cell autophagy may improve its application to wound healing. Therefore

understanding the relationship between autophagy and skin wound healing and exploring the molecular mechanism of autophagy regulation may provide novel strategies for the clinical treatment of wound healing.

关键词

Keywords

AutophagyWound healingdiabetesMesenchymal stem cellsmicroRNAskin

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