3D-bioprinted microenvironments for sweat gland regeneration

Wei Song; Bin Yao; Dongzhen Zhu; Yijie Zhang; Zhao Li; Sha Huang; Xiaobing Fu

doi:10.1093/burnst/tkab044

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3D-bioprinted microenvironments for sweat gland regeneration

更新时间：2022-06-09

- 3D-bioprinted microenvironments for sweat gland regeneration
- 3D-bioprinted microenvironments for sweat gland regeneration
- Burns & Trauma 2022年10卷第1期
- 作者机构：
  
  1. Research Center for Tissue Repair and Regeneration affiliated to the Medical Innovation Research Department, PLA General Hospital and PLA Medical College
  2. PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury
  3. Department of Cardiac Surgery
  4. Guangdong Academy of Medical Sciences
- 作者简介：
- 基金信息：
  
  This study was supported in part by the National Nature Science Foundation of China (81830064, 81721092, 32000969, 82002056) Key Support Program for Growth Factor Research (SZYZ-TR-03), Chinese PLA General Hospital for Military Medical Innovation Research Project (CX-19026), the CAMS Innovation Fund for Medical Sciences (CIFMS, 2019-I2M-5-059) and the Military Medical Research and Development Projects (AWS17J005). This study was supported in part by the Beijing National Natue Science Foundation (7204306).
- DOI：10.1093/burnst/tkab044
  中图分类号：
- 纸质出版日期：2022，
  
  网络出版日期：2022-1-21，
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3D-bioprinted microenvironments for sweat gland regeneration[J]. Burns & Trauma, 2022,10(1).

Wei Song, Bin Yao, Dongzhen Zhu, Yijie Zhang, Zhao Li, Sha Huang, Xiaobing Fu, 3D-bioprinted microenvironments for sweat gland regeneration, Burns & Trauma, Volume 10, 2022, tkab044, https://doi.org/10.1093/burnst/tkab044
3D-bioprinted microenvironments for sweat gland regeneration[J]. Burns & Trauma, 2022,10(1). DOI： 10.1093/burnst/tkab044.

Wei Song, Bin Yao, Dongzhen Zhu, Yijie Zhang, Zhao Li, Sha Huang, Xiaobing Fu, 3D-bioprinted microenvironments for sweat gland regeneration, Burns & Trauma, Volume 10, 2022, tkab044, https://doi.org/10.1093/burnst/tkab044 DOI：

摘要

Abstract

The development of 3D bioprinting in recent years has provided new insights into the creation of in vitro microenvironments for promoting stem cell-based regeneration. Sweat glands (SGs) are mainly responsible for thermoregulation and are a highly differentiated organ with limited regenerative ability. Recent studies have focused on stem cell-based therapies as strategies for repairing SGs after deep dermal injury. In this review

we highlight the recent trend in 3D bioprinted native-like microenvironments and emphasize recent advances in functional SG regeneration using this technology. Furthermore

we discuss five possible regulatory mechanisms in terms of biochemical factors and structural and mechanical cues from 3D bioprinted microenvironments

as well as the most promising regulation from neighbor cells and the vascular microenvironment.

关键词

Keywords

3D bioprintingMicroenvironmentSweat glands regenerationStem cells

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