Deciphering glial scar after spinal cord injury

Yu Zhang; Shuhai Yang; Chang Liu; Xiaoxiao Han; Xiaosong Gu; Songlin Zhou

doi:10.1093/burnst/tkab035

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Deciphering glial scar after spinal cord injury

更新时间：2022-06-14

- Deciphering glial scar after spinal cord injury
- Deciphering glial scar after spinal cord injury
- Burns & Trauma 2021年9卷第1期
- 作者机构：
  
  1. Jiangsu Province Hospital of Chinese Medicine
  2. Medical College of Nantong University
  3. Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education
  4. Nantong University
- 作者简介：
- 基金信息：
  
  This study was supported by the National Key Basic Research Program of China, No. 2017YFA0104701;The National Natural Science Foundation of China, No. 81801281, 81870975 and 81671230;and The Natural Science Foundation of Jiangsu Province (BK20202013).
- DOI：10.1093/burnst/tkab035
  中图分类号：
- 纸质出版日期：2021，
  
  网络出版日期：2021-11-8，
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Yu Zhang, Shuhai Yang, Chang Liu, 等. Deciphering glial scar after spinal cord injury[J]. Burns & Trauma, 2021,9(1).

Yu Zhang, Shuhai Yang, Chang Liu, Xiaoxiao Han, Xiaosong Gu, Songlin Zhou, Deciphering glial scar after spinal cord injury, Burns & Trauma, Volume 9, 2021, tkab035, https://doi.org/10.1093/burnst/tkab035
Yu Zhang, Shuhai Yang, Chang Liu, 等. Deciphering glial scar after spinal cord injury[J]. Burns & Trauma, 2021,9(1). DOI： 10.1093/burnst/tkab035.

Yu Zhang, Shuhai Yang, Chang Liu, Xiaoxiao Han, Xiaosong Gu, Songlin Zhou, Deciphering glial scar after spinal cord injury, Burns & Trauma, Volume 9, 2021, tkab035, https://doi.org/10.1093/burnst/tkab035 DOI：

摘要

Abstract

Spinal cord injury (SCI) often leads to permanent disability

which is mainly caused by the loss of functional recovery. In this review

we aimed to investigate why the healing process is interrupted. One of the reasons for this interruption is the formation of a glial scar around the severely damaged tissue

which is usually covered by reactive glia

macrophages and fibroblasts. Aiming to clarify this issue

we summarize the latest research findings pertaining to scar formation

tissue repair

and the divergent roles of blood-derived monocytes/macrophages

ependymal cells

fibroblasts

microglia

oligodendrocyte progenitor cells (OPCs)

neuron-glial antigen 2 (NG2) and astrocytes during the process of scar formation

and further analyse the contribution of these cells to scar formation. In addition

we recapitulate the development of therapeutic treatments targeting glial scar components. Altogether

we aim to present a comprehensive decoding of the glial scar and explore potential therapeutic strategies for improving functional recovery after SCI.

关键词

Keywords

Spinal cord injuryGlial scarAxon regenerationTherapeutic strategy

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