Ablative fractional CO2 laser surgery improving sleep quality, pain and pruritus in adult hypertrophic scar patients: a prospective cohort study

Kaiyang Lv; Huazhen Liu; Haiting Xu; Caixia Wang; Shihui Zhu; Xiaozhen Lou; Pengfei Luo; Shichu Xiao; Zhaofan Xia

doi:10.1093/burnst/tkab023

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Ablative fractional CO2 laser surgery improving sleep quality, pain and pruritus in adult hypertrophic scar patients: a prospective cohort study

更新时间：2022-06-14

- Ablative fractional CO2 laser surgery improving sleep quality, pain and pruritus in adult hypertrophic scar patients: a prospective cohort study
- Ablative fractional CO2 laser surgery improving sleep quality, pain and pruritus in adult hypertrophic scar patients: a prospective cohort study
- Burns & Trauma 2021年9卷第1期
- 作者机构：
  
  1. Department of Plastic Surgery
  2. Shanghai Jiao Tong University School of Medicine
  3. Department of Burn Surgery, the First affiliated Hospital to Naval Medical University
  4. Department of Burn and Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong University
  5. Department of Plastic Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou
  6. Shanghai Institute of Laser Technology
- 作者简介：
- 基金信息：
  
  This work was supported by the Special Scientific Research Fund of the Public Welfare Profession of China (201502028), the Excellent Discipline Leader Training Program of Shanghai Health System (No.2017BR037), the National Natural Science Foundation of China (No.81772091), Clinical Research Plan of Shanghai Hospital Development Center (No. SHDC2020CR3039B) and Shanghai Rising-Star Program (17QB1403300).
- DOI：10.1093/burnst/tkab023
  中图分类号：
- 纸质出版日期：2021，
  
  网络出版日期：2021-7-27，
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Kaiyang Lv, Huazhen Liu, Haiting Xu, 等. Ablative fractional CO2 laser surgery improving sleep quality, pain and pruritus in adult hypertrophic scar patients: a prospective cohort study[J]. Burns & Trauma, 2021,9(1).

Kaiyang Lv, Huazhen Liu, Haiting Xu, Caixia Wang, Shihui Zhu, Xiaozhen Lou, Pengfei Luo, Shichu Xiao, Zhaofan Xia, Ablative fractional CO2 laser surgery improving sleep quality, pain and pruritus in adult hypertrophic scar patients: a prospective cohort study, Burns & Trauma, Volume 9, 2021, tkab023, https://doi.org/10.1093/burnst/tkab023
Kaiyang Lv, Huazhen Liu, Haiting Xu, 等. Ablative fractional CO2 laser surgery improving sleep quality, pain and pruritus in adult hypertrophic scar patients: a prospective cohort study[J]. Burns & Trauma, 2021,9(1). DOI： 10.1093/burnst/tkab023.

Kaiyang Lv, Huazhen Liu, Haiting Xu, Caixia Wang, Shihui Zhu, Xiaozhen Lou, Pengfei Luo, Shichu Xiao, Zhaofan Xia, Ablative fractional CO2 laser surgery improving sleep quality, pain and pruritus in adult hypertrophic scar patients: a prospective cohort study, Burns & Trauma, Volume 9, 2021, tkab023, https://doi.org/10.1093/burnst/tkab023 DOI：

摘要

Abstract

BackgroundPoor sleep quality is associated with a decrease in quality of life in patients with major burn scars

combined with pruritus and pain. Few interventions have been reported to improve the sleep quality of patients with scars. In the current prospective cohort study

we investigated the efficacy of CO2-ablative fractional laser (AFL) surgery vs conventional surgery in post-burn patients with hypertrophic scars with sleep quality as the primary study outcome.MethodsIn total 68 consecutive patients undergoing scar surgical treatment were recruited

including a CO2-AFL surgery cohort (n = 35) and a conventional surgery cohort (n = 33). A subgroup from the AFL cohort was selected. Sleep quality

pain and pruritus were evaluated. Multiple linear regression analyses were performed to reveal the effect of CO2-AFL surgery.ResultsThe CO2-AFL surgery cohort had significantly lower Pittsburgh sleep quality index (PSQI) global scores than the conventional surgery cohort after the last surgical treatment. In the subgroup of patients receiving hardware sleep monitoring

CO2-AFL markedly increased deep sleep time

deep sleep efficiency and reduced initial sleep latency. Compared to the conventional surgery cohort

the CO2-AFL cohort presented significantly lower pain and pruritus scores. Correlation analysis showed pain and pruritus were significantly associated with PSQI scores

and there were also significant correlations between pain and pruritus scores. Multiple linear regression analysis showed that surgery method was negatively linearly correlated with visual analog scale (VAS) pain score

brief pain inventory (BPI) total

VAS pruritus score

5-D itch scale total

four-item itch questionnaire (FIIQ) total and PSQI total.ConclusionsCO2-AFL surgery significantly improved sleep quality and reduced pain and pruritus of hypertrophic scar patients. The alleviation of sleep disorder was associated with improvement of deep sleep quality including deep sleep time and deep sleep deficiency.Trial registrationThe Chinese Clinical Trial Registry (ChiCTR200035268) approved retrospectively registration on 5 Aug 2020.

关键词

Keywords

Burn scarAblative CO2 fractional laserCardiopulmonary couplingSleep qualityPainPruritus

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